Program Solicitation NSF 21-543

National Science Foundation Directorate for Biological Sciences

Full Proposal Deadline(s) (due by 5 p.m. submitter's local time):

     March 16, 2021

     January 25, 2022

     Fourth Tuesday in January, Annually Thereafter

Important Information And Revision Notes

The Integrative Research in Biology program replaces the Rules of Life track, which was previously a part of the core program solicitations in the four Divisions of the Directorate for Biological Sciences. The Integrative Research in Biology program refines and expands the former submission track.

Innovating and migrating proposal preparation and submission capabilities from FastLane to Research.gov is part of the ongoing NSF information technology modernization efforts, as described in Important Notice No. 147. In October, the Directorate for Biological Sciences announced that it is now requiring the use of Research.gov for the preparation and submission of proposals in response to its core programs that do not have deadline dates (see Dear Colleague Letter NSF 20-129). In accordance with that requirement, full research proposals submitted in response to this program solicitation must be prepared and submitted via Research.gov. Proposals also may continue to be submitted via use of Grants.gov.

NSF is taking proactive steps to move the preparation and submission of all proposals from FastLane to Research.gov, however until capabilities are fully implemented, the other types of proposals outlined in Chapter II.E of the NSF Proposal & Award Policies & Procedures Guide (PAPPG), as well as accomplishment-based renewal proposals, must be prepared and submitted via FastLane or Grants.gov in accordance with the applicable guidance contained in the PAPPG or the NSF Grants.gov Application Guide.

Any proposal submitted in response to this solicitation should be submitted in accordance with the revised NSF Proposal & Award Policies & Procedures Guide (PAPPG) (NSF 20-1), which is effective for proposals submitted, or due, on or after June 1, 2020.

Summary Of Program Requirements

General Information

Program Title:

Integrative Research in Biology (IntBIO)

Synopsis of Program:

This solicitation invites submission of collaborative proposals that tackle bold questions in biology and require an integrated approach to make substantive progress. Integrative biological research spans subdisciplines and incorporates cutting-edge methods, tools, and concepts from each to produce groundbreaking biological discovery. The research should be synergistic and produce novel, holistic understanding of how biological systems function and interact across different scales of organization, e.g., from molecules to cells, tissues to organisms, species to ecosystems and the entire Earth. Such knowledge is critical to inform solutions to societal challenges, including natural resource management, resilience to environmental change, and global food security. Outcomes from integrative research will also inform and guide the development of new technologies that drive the nation’s bioeconomy.

Integrative biological research depends on researchers who work in dynamic, diverse, and collaborative interdisciplinary teams. These teams should be fully engaged in the training and education of the next generation of scientists who will be future leaders in integrative research. A vibrant, inclusive, and integrative training environment will therefore produce a new generation of researchers who can navigate across subdisciplines and engage in integrative thinking.

Cognizant Program Officer(s):

Please note that the following information is current at the time of publishing. See program website for any updates to the points of contact.

• Karen C. Cone, Program Director, BIO/MCB, telephone: (703) 292-4967, email: kccone@nsf.gov

• Elizabeth R. Blood, Program Director, BIO/DEB, telephone: (703) 292-4349, email: eblood@nsf.gov

• Matthew Herron, Program Director, BIO/DEB, telephone: (703) 292-5361, email: mherron@nsf.gov

• Daniel R. Marenda, telephone: (703) 292-2157, email: dmarenda@nsf.gov

• David Rockcliffe, Program Director, BIO/MCB, telephone: (703) 292-7123, email: drockcli@nsf.gov

• Joanna Shisler, Program Director, BIO/IOS, telephone: (703) 292-5368, email: jshisler@nsf.gov

• Anne W. Sylvester, Program Director, BIO/IOS, telephone: (703) 292-7168, email: asylvest@nsf.gov

Applicable Catalog of Federal Domestic Assistance (CFDA) Number(s):

• 47.074 --- Biological Sciences

Award Information

Anticipated Type of Award: Standard Grant or Continuing Grant

Estimated Number of Awards: 10 to 20

Anticipated Funding Amount: $15,000,000 to $20,000,000

Subject to the availability of funds

Eligibility Information

Who May Submit Proposals:

Proposals may only be submitted by the following:

• Institutions of Higher Education (IHEs) - Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of subawards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus.
• Non-profit, non-academic organizations: Independent museums, observatories, research labs, professional societies and similar organizations in the U.S. associated with educational or research activities.

Who May Serve as PI:

There are no restrictions or limits.

Limit on Number of Proposals per Organization:

There are no restrictions or limits.

Limit on Number of Proposals per PI or Co-PI:

There are no restrictions or limits.

Proposal Preparation and Submission Instructions

A. Proposal Preparation Instructions

• Letters of Intent: Not required

• Preliminary Proposal Submission: Not required

• Full Proposals:

  • Full Proposals submitted via Research.gov: NSF Proposal and Award Policies and Procedures Guide (PAPPG) guidelines apply. The complete text of the PAPPG is available electronically on the NSF website at: https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg.
  • Full Proposals submitted via Grants.gov: NSF Grants.gov Application Guide: A Guide for the Preparation and Submission of NSF Applications via Grants.gov guidelines apply (Note: The NSF Grants.gov Application Guide is available on the Grants.gov website and on the NSF website at: https://www.nsf.gov/publications/pub_summ.jsp?ods_key=grantsgovguide).

B. Budgetary Information

• Cost Sharing Requirements:

  Inclusion of voluntary committed cost sharing is prohibited.

• Indirect Cost (F&A) Limitations:

  Not Applicable

• Other Budgetary Limitations:

  Not Applicable

C. Due Dates

• Full Proposal Deadline(s) (due by 5 p.m. submitter's local time):

       March 16, 2021

       January 25, 2022

       Fourth Tuesday in January, Annually Thereafter

Proposal Review Information Criteria

Merit Review Criteria:

National Science Board approved criteria. Additional merit review criteria apply. Please see the full text of this solicitation for further information.

Award Administration Information

Award Conditions:

Standard NSF award conditions apply.

Reporting Requirements:

Standard NSF reporting requirements apply.

I. Introduction

The pace of biological discovery has accelerated in recent decades. Breakthroughs in subdisciplines of biology, often facilitated by advanced instrumentation, computation, and analytics, provide new insight into biological organization and the underlying principles that govern life processes. In some cases, these insights have been made possible only through integrative research that reaches across specialized subdisciplines of biology. Leveraging the synergism from such integrative activity can reveal a holistic understanding of how biological systems function and interact. Such knowledge is critical to inform important, societally relevant decision-making and solutions, impacting not only management of the natural world and its resources, but also development of new biotechnologies that drive the bioeconomy.

Integrative research in biology requires synergistic training that will prepare the next generation of scientists to tackle complex scientific questions using interdisciplinary approaches. To address future workforce needs, training opportunities must engage groups of researchers who reflect the diversity of people, both within biology and across the nation. Integrative training should produce scientists who can communicate across subdisciplines and address scientific questions using diverse approaches and skills. Effective training and education will produce future scientists for whom integrative thinking and practice are natural ways to advance scientific discovery. The success of the scientific enterprise depends on the ability of researchers and trainees to work together in dynamic, diverse, and collaborative interdisciplinary teams.

The National Science Foundation (NSF) Directorate of Biological Sciences (BIO) is particularly interested in increasing the participation of underrepresented groups in biological research and education such as women, persons with disabilities, underrepresented minorities ^[1][2], and those from geographically underrepresented areas in science, technology, engineering, and mathematics (STEM). Proposals submitted to any program described in this solicitation are strongly encouraged to substantively involve PIs, co-PIs, postdoctoral fellows, students, and other personnel who are members of these groups. Proposers are also strongly encouraged to consider involving veterans of the U.S. Armed Forces as part of NSF’s broader effort to promote veteran involvement in STEM research and education.

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[1] https://ncses.nsf.gov/pubs/nsf19304/digest/introduction

[2] https://www.nsf.gov/od/oia/activities/ceose/reports/CEOSE_ReportToCongress_RP_FVmp_508.pdf

II. Program Description

The Integrative Research in Biology (IntBIO) program invites collaborative proposals that address fundamental biological questions requiring integrative approaches across two or more subdisciplines of biology to discover underlying principles operating across hierarchical levels of life. The research may also incorporate approaches from disciplines outside of biology, as appropriate. Projects should be motivated by a conceptual framework of hypothesis-driven research, guided by experimental, theoretical, or modeling approaches, to test novel ideas and that will uncover principles underlying the function and interaction of biological systems across organizational scales. The goal for this program is two-fold: (1) to support collaborative researchers who engage in innovative, integrative biological research to address fundamental questions that cross different scales of organization—from molecules to cells, tissues to organisms, species to ecosystems and the entire Earth—and are yet to be answered by a single subdiscipline alone, and (2) to prepare a new generation of scientists who reflect the diversity of the nation and are ready to contribute to the future research enterprise through integrative approaches.

Projects should address bold biological questions or significant technological challenges that can only be resolved by integrating perspectives and approaches from different biological subdisciplines. The proposal should describe the subdisciplines being incorporated, the hierarchical scales to be explored, and the integrative approaches. Where appropriate, projects should apply experimental strategies, modeling, integrative analysis, advanced computation, or other research approaches to stimulate new discovery and general theory in biology.

IntBIO is supported as part of BIO’s continuing investment in efforts to integrate biology across subdisciplines and to explore new collaborations in an integrative environment. Through a formal community engagement opportunity, BIO recently sponsored a series of Reintegrating Biology activities that culminated in production of a set of vision papers authored by members of the biological research community (https://reintegratingbiology.org/vision-papers/). Some of these papers present questions that could be appropriate for this solicitation. However, these examples are not exclusive or exhaustive, and other topics are welcome.

IntBIO also synergizes with other current BIO activities and programs focused on integration, including Postdoctoral Research Fellowships in Biology (NSF 20-602, Competitive Area 2: Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment and Phenotypes) and Biology Integration Institutes (NSF 20-601). Projects supported by IntBIO will differ from Biology Integration Institutes in the scale of the research and training programs; for example, IntBIO projects may bring together a smaller cohort of researchers to focus on probing one system.

IntBIO replaces the former Rules of Life Track in the core solicitations of the four Divisions in BIO. Consistent with the original BIO Rules of Life funding mechanism, IntBIO aims to support projects that would not traditionally be supported through a single divisional core program in BIO ^[3], because the questions addressed require broad approaches that span traditional disciplinary boundaries within biology. Projects suitable for review in a single divisional core program are not eligible for support through IntBIO and should be submitted to the relevant core programs solicitation. For example, some core programs, such as Integrative Ecological Physiology in the Division of Integrative Organismal Systems and Bridging Ecology and Evolution in the Division of Environmental Biology, are inherently integrative and may be a better option for certain proposals than IntBIO. Further, projects focused on generating datasets, tools, technologies, or other infrastructure for biological integration are encouraged to submit proposals to Infrastructure Innovation for Biological Research or Infrastructure Capacity for Biological Research in the Division of Biological Infrastructure. Proposers are strongly encouraged to contact the Program Directors prior to submission with any questions about research ideas, scope, and fit for IntBIO and these other programs.

The goal of the IntBIO program is to support proposals addressing compelling biological questions that cannot be addressed effectively without the synergy from integrative approaches combining biological subdisciplines.

To facilitate proposal planning, the following guidance is provided:

1. Bold questions using an integrative approach. The proposal should articulate a fundamental overarching biological question that is addressed through integrative and hypothesis-driven research. The project should focus on the discovery of new principles underlying function or interaction of biological systems across different scales of organization that can only be solved through integrative research or by the development of tools or technologies for integrative analysis and discovery. The research should cut across biological subdisciplines and hierarchical organizational scales and go beyond what could be proposed to a single BIO Core Program.
2. Nature of the integration and synergistic outcomes. The proposal must explicitly define and describe the interdependent, integrative components of the research and how the integration is expected to produce outcomes that are synergistic, i.e., greater than the sum of the individual parts. It should be noted that whereas this solicitation requires the integration of biological subdisciplines, any field beyond biology may also be included, as needed, to address the overarching biological question.
3. Graphical illustration. The proposed research plan must include a graphical illustration to convey how integration will be accomplished through interconnection between subdisciplines, elements, or systems. The graphic can be referenced to explain integrated strategies that will lead to a synergistic outcome.
4. Collaborative team. Investigative teams should be optimally configured to achieve the goals of the proposed work, including two or more investigators with diverse perspectives and expertise. The role of each team member must be clearly described and justified. Team members may be from a single organization or multiple organizations. Budgets should be commensurate with the project goals.
5. Training, inclusion, and diversity plans. Proposals must describe a training and education plan, as part of broader impacts, that is inclusive and likely to produce a new generation of diverse scientists who are trained in integrative approaches to biological research. The roles and interactions of each participant in both research and training activities must be clearly described. Plans to advance inclusion and diversity as an outcome of the project should be clearly explained.

Proposers are strongly encouraged to contact the Program Directors prior to submission with any questions about research ideas, scope, budgets, and submission mechanisms for collaborative projects.

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[3] Solicitations for Core Programs in BIO are: Division of Biological Infrastructure (NSF 21-502 for Research, NSF 21-501 and NSF 21-503 for Research Resources); Division of Environmental Biology (NSF 21-504); Division of Integrative Organismal Systems (NSF 21-506); and Division of Molecular and Cellular Biosciences (NSF 21-509).

III. Award Information

Anticipated Type of Award: Standard Grant or Continuing Grant

Estimated Number of Awards: 10 to 20

Anticipated Funding Amount: $15,000,000 to $20,000,000, subject to the availability of funds

IV. Eligibility Information

Who May Submit Proposals:

Proposals may only be submitted by the following:

• Institutions of Higher Education (IHEs) - Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of subawards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus.
• Non-profit, non-academic organizations: Independent museums, observatories, research labs, professional societies and similar organizations in the U.S. associated with educational or research activities.

Who May Serve as PI:

There are no restrictions or limits.

Limit on Number of Proposals per Organization:

There are no restrictions or limits.

Limit on Number of Proposals per PI or Co-PI:

There are no restrictions or limits.

V. Proposal Preparation And Submission Instructions

A. Proposal Preparation Instructions

Full Proposal Preparation Instructions: Proposers may opt to submit proposals in response to this Program Solicitation via Research.gov or Grants.gov.

• Full Proposals submitted via Research.gov: Proposals submitted in response to this program solicitation should be prepared and submitted in accordance with the general guidelines contained in the NSF Proposal and Award Policies and Procedures Guide (PAPPG). The complete text of the PAPPG is available electronically on the NSF website at: https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg. Paper copies of the PAPPG may be obtained from the NSF Publications Clearinghouse, telephone (703) 292-8134 or by e-mail from nsfpubs@nsf.gov. The Prepare New Proposal setup will prompt you for the program solicitation number.
• Full proposals submitted via Grants.gov: Proposals submitted in response to this program solicitation via Grants.gov should be prepared and submitted in accordance with the NSF Grants.gov Application Guide: A Guide for the Preparation and Submission of NSF Applications via Grants.gov. The complete text of the NSF Grants.gov Application Guide is available on the Grants.gov website and on the NSF website at: (https://www.nsf.gov/publications/pub_summ.jsp?ods_key=grantsgovguide). To obtain copies of the Application Guide and Application Forms Package, click on the Apply tab on the Grants.gov site, then click on the Apply Step 1: Download a Grant Application Package and Application Instructions link and enter the funding opportunity number, (the program solicitation number without the NSF prefix) and press the Download Package button. Paper copies of the Grants.gov Application Guide also may be obtained from the NSF Publications Clearinghouse, telephone (703) 292-8134 or by e-mail from nsfpubs@nsf.gov.

In determining which method to utilize in the electronic preparation and submission of the proposal, please note the following:

Collaborative Proposals. All collaborative proposals submitted as separate submissions from multiple organizations must be submitted via Research.gov. PAPPG Chapter II.D.3 provides additional information on collaborative proposals.

See PAPPG Chapter II.C.2 for guidance on the required sections of a full research proposal submitted to NSF. Please note that the proposal preparation instructions provided in this program solicitation may deviate from the PAPPG instructions.

B. Budgetary Information

Cost Sharing:

Inclusion of voluntary committed cost sharing is prohibited.

C. Due Dates

• Full Proposal Deadline(s) (due by 5 p.m. submitter's local time):

       March 16, 2021

       January 25, 2022

       Fourth Tuesday in January, Annually Thereafter

D. Research.gov/Grants.gov Requirements

For Proposals Submitted Via Research.gov:

To prepare and submit a proposal via Research.gov, see detailed technical instructions available at: https://www.research.gov/research-portal/appmanager/base/desktop?_nfpb=true&_pageLabel=research_node_display&_nodePath=/researchGov/Service/Desktop/ProposalPreparationandSubmission.html. For Research.gov user support, call the Research.gov Help Desk at 1-800-673-6188 or e-mail rgov@nsf.gov. The Research.gov Help Desk answers general technical questions related to the use of the Research.gov system. Specific questions related to this program solicitation should be referred to the NSF program staff contact(s) listed in Section VIII of this funding opportunity.

For Proposals Submitted Via Grants.gov:

Before using Grants.gov for the first time, each organization must register to create an institutional profile. Once registered, the applicant's organization can then apply for any federal grant on the Grants.gov website. Comprehensive information about using Grants.gov is available on the Grants.gov Applicant Resources webpage: https://www.grants.gov/web/grants/applicants.html. In addition, the NSF Grants.gov Application Guide (see link in Section V.A) provides instructions regarding the technical preparation of proposals via Grants.gov. For Grants.gov user support, contact the Grants.gov Contact Center at 1-800-518-4726 or by email: support@grants.gov. The Grants.gov Contact Center answers general technical questions related to the use of Grants.gov. Specific questions related to this program solicitation should be referred to the NSF program staff contact(s) listed in Section VIII of this solicitation.

Submitting the Proposal: Once all documents have been completed, the Authorized Organizational Representative (AOR) must submit the application to Grants.gov and verify the desired funding opportunity and agency to which the application is submitted. The AOR must then sign and submit the application to Grants.gov. The completed application will be transferred to the NSF FastLane system for further processing.

Proposers that submitted via Research.gov may use Research.gov to verify the status of their submission to NSF. For proposers that submitted via Grants.gov, until an application has been received and validated by NSF, the Authorized Organizational Representative may check the status of an application on Grants.gov. After proposers have received an e-mail notification from NSF, Research.gov should be used to check the status of an application.

VI. NSF Proposal Processing And Review Procedures

Proposals received by NSF are assigned to the appropriate NSF program for acknowledgement and, if they meet NSF requirements, for review. All proposals are carefully reviewed by a scientist, engineer, or educator serving as an NSF Program Officer, and usually by three to ten other persons outside NSF either as ad hoc reviewers, panelists, or both, who are experts in the particular fields represented by the proposal. These reviewers are selected by Program Officers charged with oversight of the review process. Proposers are invited to suggest names of persons they believe are especially well qualified to review the proposal and/or persons they would prefer not review the proposal. These suggestions may serve as one source in the reviewer selection process at the Program Officer's discretion. Submission of such names, however, is optional. Care is taken to ensure that reviewers have no conflicts of interest with the proposal. In addition, Program Officers may obtain comments from site visits before recommending final action on proposals. Senior NSF staff further review recommendations for awards. A flowchart that depicts the entire NSF proposal and award process (and associated timeline) is included in PAPPG Exhibit III-1.

A comprehensive description of the Foundation's merit review process is available on the NSF website at: https://www.nsf.gov/bfa/dias/policy/merit_review/.

Proposers should also be aware of core strategies that are essential to the fulfillment of NSF's mission, as articulated in Building the Future: Investing in Discovery and Innovation - NSF Strategic Plan for Fiscal Years (FY) 2018 – 2022. These strategies are integrated in the program planning and implementation process, of which proposal review is one part. NSF's mission is particularly well-implemented through the integration of research and education and broadening participation in NSF programs, projects, and activities.

One of the strategic objectives in support of NSF's mission is to foster integration of research and education through the programs, projects, and activities it supports at academic and research institutions. These institutions must recruit, train, and prepare a diverse STEM workforce to advance the frontiers of science and participate in the U.S. technology-based economy. NSF's contribution to the national innovation ecosystem is to provide cutting-edge research under the guidance of the Nation's most creative scientists and engineers. NSF also supports development of a strong science, technology, engineering, and mathematics (STEM) workforce by investing in building the knowledge that informs improvements in STEM teaching and learning.

NSF's mission calls for the broadening of opportunities and expanding participation of groups, institutions, and geographic regions that are underrepresented in STEM disciplines, which is essential to the health and vitality of science and engineering. NSF is committed to this principle of diversity and deems it central to the programs, projects, and activities it considers and supports.

A. Merit Review Principles and Criteria

The National Science Foundation strives to invest in a robust and diverse portfolio of projects that creates new knowledge and enables breakthroughs in understanding across all areas of science and engineering research and education. To identify which projects to support, NSF relies on a merit review process that incorporates consideration of both the technical aspects of a proposed project and its potential to contribute more broadly to advancing NSF's mission "to promote the progress of science; to advance the national health, prosperity, and welfare; to secure the national defense; and for other purposes." NSF makes every effort to conduct a fair, competitive, transparent merit review process for the selection of projects.

1. Merit Review Principles

These principles are to be given due diligence by PIs and organizations when preparing proposals and managing projects, by reviewers when reading and evaluating proposals, and by NSF program staff when determining whether or not to recommend proposals for funding and while overseeing awards. Given that NSF is the primary federal agency charged with nurturing and supporting excellence in basic research and education, the following three principles apply:

• All NSF projects should be of the highest quality and have the potential to advance, if not transform, the frontiers of knowledge.
• NSF projects, in the aggregate, should contribute more broadly to achieving societal goals. These "Broader Impacts" may be accomplished through the research itself, through activities that are directly related to specific research projects, or through activities that are supported by, but are complementary to, the project. The project activities may be based on previously established and/or innovative methods and approaches, but in either case must be well justified.
• Meaningful assessment and evaluation of NSF funded projects should be based on appropriate metrics, keeping in mind the likely correlation between the effect of broader impacts and the resources provided to implement projects. If the size of the activity is limited, evaluation of that activity in isolation is not likely to be meaningful. Thus, assessing the effectiveness of these activities may best be done at a higher, more aggregated, level than the individual project.

With respect to the third principle, even if assessment of Broader Impacts outcomes for particular projects is done at an aggregated level, PIs are expected to be accountable for carrying out the activities described in the funded project. Thus, individual projects should include clearly stated goals, specific descriptions of the activities that the PI intends to do, and a plan in place to document the outputs of those activities.

These three merit review principles provide the basis for the merit review criteria, as well as a context within which the users of the criteria can better understand their intent.

2. Merit Review Criteria

All NSF proposals are evaluated through use of the two National Science Board approved merit review criteria. In some instances, however, NSF will employ additional criteria as required to highlight the specific objectives of certain programs and activities.

The two merit review criteria are listed below. Both criteria are to be given full consideration during the review and decision-making processes; each criterion is necessary but neither, by itself, is sufficient. Therefore, proposers must fully address both criteria. (PAPPG Chapter II.C.2.d(i). contains additional information for use by proposers in development of the Project Description section of the proposal). Reviewers are strongly encouraged to review the criteria, including PAPPG Chapter II.C.2.d(i), prior to the review of a proposal.

When evaluating NSF proposals, reviewers will be asked to consider what the proposers want to do, why they want to do it, how they plan to do it, how they will know if they succeed, and what benefits could accrue if the project is successful. These issues apply both to the technical aspects of the proposal and the way in which the project may make broader contributions. To that end, reviewers will be asked to evaluate all proposals against two criteria:

• Intellectual Merit: The Intellectual Merit criterion encompasses the potential to advance knowledge; and
• Broader Impacts: The Broader Impacts criterion encompasses the potential to benefit society and contribute to the achievement of specific, desired societal outcomes.

The following elements should be considered in the review for both criteria:

1. What is the potential for the proposed activity to
   1. Advance knowledge and understanding within its own field or across different fields (Intellectual Merit); and
   2. Benefit society or advance desired societal outcomes (Broader Impacts)?
2. To what extent do the proposed activities suggest and explore creative, original, or potentially transformative concepts?
3. Is the plan for carrying out the proposed activities well-reasoned, well-organized, and based on a sound rationale? Does the plan incorporate a mechanism to assess success?
4. How well qualified is the individual, team, or organization to conduct the proposed activities?
5. Are there adequate resources available to the PI (either at the home organization or through collaborations) to carry out the proposed activities?

Broader impacts may be accomplished through the research itself, through the activities that are directly related to specific research projects, or through activities that are supported by, but are complementary to, the project. NSF values the advancement of scientific knowledge and activities that contribute to achievement of societally relevant outcomes. Such outcomes include, but are not limited to: full participation of women, persons with disabilities, and underrepresented minorities in science, technology, engineering, and mathematics (STEM); improved STEM education and educator development at any level; increased public scientific literacy and public engagement with science and technology; improved well-being of individuals in society; development of a diverse, globally competitive STEM workforce; increased partnerships between academia, industry, and others; improved national security; increased economic competitiveness of the United States; and enhanced infrastructure for research and education.

Proposers are reminded that reviewers will also be asked to review the Data Management Plan and the Postdoctoral Researcher Mentoring Plan, as appropriate.

Additional Solicitation Specific Review Criteria

1. Does the proposal describe an overarching question that is addressed through bold, integrative, hypothesis-driven research aimed at discovery of new principles underlying function or interaction of biological systems across different scales of organization, and is the overarching question one that can only be solved through integration across biological subdisciplines or development of tools or technology for integrative analysis and discovery?
2. Does the proposal describe the interdependent, integrative components of the research and how the integration is expected to produce outcomes that are synergistic, i.e., greater than the sum of the individual parts?
3. Does the proposal include a graphical illustration that effectively conveys how integration will be accomplished and will lead to synergistic outcomes?
4. Does the proposal provide a clear description of the investigative team, the roles of each member, and evidence that they are well-positioned to achieve the goals of the proposed work?
5. Does the proposal describe a training and education plan, as part of broader impacts, that is inclusive and likely to produce a new generation of diverse scientists who are trained in integrative approaches to biological research? Is the plan for advancing inclusion and diversity across the team well-described?

B. Review and Selection Process

Proposals submitted in response to this program solicitation will be reviewed by Ad hoc Review and/or Panel Review.

Reviewers will be asked to evaluate proposals using two National Science Board approved merit review criteria and, if applicable, additional program specific criteria. A summary rating and accompanying narrative will generally be completed and submitted by each reviewer and/or panel. The Program Officer assigned to manage the proposal's review will consider the advice of reviewers and will formulate a recommendation.

After scientific, technical and programmatic review and consideration of appropriate factors, the NSF Program Officer recommends to the cognizant Division Director whether the proposal should be declined or recommended for award. NSF strives to be able to tell applicants whether their proposals have been declined or recommended for funding within six months. Large or particularly complex proposals or proposals from new awardees may require additional review and processing time. The time interval begins on the deadline or target date, or receipt date, whichever is later. The interval ends when the Division Director acts upon the Program Officer's recommendation.

After programmatic approval has been obtained, the proposals recommended for funding will be forwarded to the Division of Grants and Agreements for review of business, financial, and policy implications. After an administrative review has occurred, Grants and Agreements Officers perform the processing and issuance of a grant or other agreement. Proposers are cautioned that only a Grants and Agreements Officer may make commitments, obligations or awards on behalf of NSF or authorize the expenditure of funds. No commitment on the part of NSF should be inferred from technical or budgetary discussions with a NSF Program Officer. A Principal Investigator or organization that makes financial or personnel commitments in the absence of a grant or cooperative agreement signed by the NSF Grants and Agreements Officer does so at their own risk.

Once an award or declination decision has been made, Principal Investigators are provided feedback about their proposals. In all cases, reviews are treated as confidential documents. Verbatim copies of reviews, excluding the names of the reviewers or any reviewer-identifying information, are sent to the Principal Investigator/Project Director by the Program Officer. In addition, the proposer will receive an explanation of the decision to award or decline funding.

VII. Award Administration Information

A. Notification of the Award

Notification of the award is made to the submitting organization by a Grants Officer in the Division of Grants and Agreements. Organizations whose proposals are declined will be advised as promptly as possible by the cognizant NSF Program administering the program. Verbatim copies of reviews, not including the identity of the reviewer, will be provided automatically to the Principal Investigator. (See Section VI.B. for additional information on the review process.)

B. Award Conditions

An NSF award consists of: (1) the award notice, which includes any special provisions applicable to the award and any numbered amendments thereto; (2) the budget, which indicates the amounts, by categories of expense, on which NSF has based its support (or otherwise communicates any specific approvals or disapprovals of proposed expenditures); (3) the proposal referenced in the award notice; (4) the applicable award conditions, such as Grant General Conditions (GC-1)*; or Research Terms and Conditions* and (5) any announcement or other NSF issuance that may be incorporated by reference in the award notice. Cooperative agreements also are administered in accordance with NSF Cooperative Agreement Financial and Administrative Terms and Conditions (CA-FATC) and the applicable Programmatic Terms and Conditions. NSF awards are electronically signed by an NSF Grants and Agreements Officer and transmitted electronically to the organization via e-mail.

*These documents may be accessed electronically on NSF's Website at https://www.nsf.gov/awards/managing/award_conditions.jsp?org=NSF. Paper copies may be obtained from the NSF Publications Clearinghouse, telephone (703) 292-8134 or by e-mail from nsfpubs@nsf.gov.

More comprehensive information on NSF Award Conditions and other important information on the administration of NSF awards is contained in the NSF Proposal & Award Policies & Procedures Guide (PAPPG) Chapter VII, available electronically on the NSF Website at https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg.

C. Reporting Requirements

For all multi-year grants (including both standard and continuing grants), the Principal Investigator must submit an annual project report to the cognizant Program Officer no later than 90 days prior to the end of the current budget period. (Some programs or awards require submission of more frequent project reports). No later than 120 days following expiration of a grant, the PI also is required to submit a final project report, and a project outcomes report for the general public.

Failure to provide the required annual or final project reports, or the project outcomes report, will delay NSF review and processing of any future funding increments as well as any pending proposals for all identified PIs and co-PIs on a given award. PIs should examine the formats of the required reports in advance to assure availability of required data.

PIs are required to use NSF's electronic project-reporting system, available through Research.gov, for preparation and submission of annual and final project reports. Such reports provide information on accomplishments, project participants (individual and organizational), publications, and other specific products and impacts of the project. Submission of the report via Research.gov constitutes certification by the PI that the contents of the report are accurate and complete. The project outcomes report also must be prepared and submitted using Research.gov. This report serves as a brief summary, prepared specifically for the public, of the nature and outcomes of the project. This report will be posted on the NSF website exactly as it is submitted by the PI.

More comprehensive information on NSF Reporting Requirements and other important information on the administration of NSF awards is contained in the NSF Proposal & Award Policies & Procedures Guide (PAPPG) Chapter VII, available electronically on the NSF Website at https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg.

VIII. Agency Contacts

Please note that the program contact information is current at the time of publishing. See program website for any updates to the points of contact.

General inquiries regarding this program should be made to:

• Karen C. Cone, Program Director, BIO/MCB, telephone: (703) 292-4967, email: kccone@nsf.gov

• Elizabeth R. Blood, Program Director, BIO/DEB, telephone: (703) 292-4349, email: eblood@nsf.gov

• Matthew Herron, Program Director, BIO/DEB, telephone: (703) 292-5361, email: mherron@nsf.gov

• Daniel R Marenda, telephone: (703) 292-2157, email: dmarenda@nsf.gov

• David Rockcliffe, Program Director, BIO/MCB, telephone: (703) 292-7123, email: drockcli@nsf.gov

• Joanna Shisler, Program Director, BIO/IOS, telephone: (703) 292-5368, email: jshisler@nsf.gov

• Anne W. Sylvester, Program Director, BIO/IOS, telephone: (703) 292-7168, email: asylvest@nsf.gov

For questions related to the use of FastLane or Research.gov, contact:

• FastLane and Research.gov Help Desk: 1-800-673-6188
• FastLane Help Desk e-mail: fastlane@nsf.gov.
• Research.gov Help Desk e-mail: rgov@nsf.gov

For questions relating to Grants.gov contact:

• Grants.gov Contact Center: If the Authorized Organizational Representatives (AOR) has not received a confirmation message from Grants.gov within 48 hours of submission of application, please contact via telephone: 1-800-518-4726; e-mail: support@grants.gov.

IX. Other Information

The NSF website provides the most comprehensive source of information on NSF Directorates (including contact information), programs and funding opportunities. Use of this website by potential proposers is strongly encouraged. In addition, "NSF Update" is an information-delivery system designed to keep potential proposers and other interested parties apprised of new NSF funding opportunities and publications, important changes in proposal and award policies and procedures, and upcoming NSF Grants Conferences. Subscribers are informed through e-mail or the user's Web browser each time new publications are issued that match their identified interests. "NSF Update" also is available on NSF's website.

Grants.gov provides an additional electronic capability to search for Federal government-wide grant opportunities. NSF funding opportunities may be accessed via this mechanism. Further information on Grants.gov may be obtained at https://www.grants.gov.

About The National Science Foundation

The National Science Foundation (NSF) is an independent Federal agency created by the National Science Foundation Act of 1950, as amended (42 USC 1861-75). The Act states the purpose of the NSF is "to promote the progress of science; [and] to advance the national health, prosperity, and welfare by supporting research and education in all fields of science and engineering."

NSF funds research and education in most fields of science and engineering. It does this through grants and cooperative agreements to more than 2,000 colleges, universities, K-12 school systems, businesses, informal science organizations and other research organizations throughout the US. The Foundation accounts for about one-fourth of Federal support to academic institutions for basic research.

NSF receives approximately 55,000 proposals each year for research, education and training projects, of which approximately 11,000 are funded. In addition, the Foundation receives several thousand applications for graduate and postdoctoral fellowships. The agency operates no laboratories itself but does support National Research Centers, user facilities, certain oceanographic vessels and Arctic and Antarctic research stations. The Foundation also supports cooperative research between universities and industry, US participation in international scientific and engineering efforts, and educational activities at every academic level.

Facilitation Awards for Scientists and Engineers with Disabilities (FASED) provide funding for special assistance or equipment to enable persons with disabilities to work on NSF-supported projects. See the NSF Proposal & Award Policies & Procedures Guide Chapter II.E.6 for instructions regarding preparation of these types of proposals.

The National Science Foundation has Telephonic Device for the Deaf (TDD) and Federal Information Relay Service (FIRS) capabilities that enable individuals with hearing impairments to communicate with the Foundation about NSF programs, employment or general information. TDD may be accessed at (703) 292-5090 and (800) 281-8749, FIRS at (800) 877-8339.

The National Science Foundation Information Center may be reached at (703) 292-5111.

The National Science Foundation promotes and advances scientific progress in the United States by competitively awarding grants and cooperative agreements for research and education in the sciences, mathematics, and engineering. To get the latest information about program deadlines, to download copies of NSF publications, and to access abstracts of awards, visit the NSF Website at https://www.nsf.gov Location: 2415 Eisenhower Avenue, Alexandria, VA 22314 For General Information (NSF Information Center): (703) 292-5111 TDD (for the hearing-impaired): (703) 292-5090 To Order Publications or Forms: Send an e-mail to: nsfpubs@nsf.gov or telephone: (703) 292-8134 To Locate NSF Employees: (703) 292-5111

Privacy Act And Public Burden Statements

The information requested on proposal forms and project reports is solicited under the authority of the National Science Foundation Act of 1950, as amended. The information on proposal forms will be used in connection with the selection of qualified proposals; and project reports submitted by awardees will be used for program evaluation and reporting within the Executive Branch and to Congress. The information requested may be disclosed to qualified reviewers and staff assistants as part of the proposal review process; to proposer institutions/grantees to provide or obtain data regarding the proposal review process, award decisions, or the administration of awards; to government contractors, experts, volunteers and researchers and educators as necessary to complete assigned work; to other government agencies or other entities needing information regarding applicants or nominees as part of a joint application review process, or in order to coordinate programs or policy; and to another Federal agency, court, or party in a court or Federal administrative proceeding if the government is a party. Information about Principal Investigators may be added to the Reviewer file and used to select potential candidates to serve as peer reviewers or advisory committee members. See System of Record Notices, NSF-50, "Principal Investigator/Proposal File and Associated Records," and NSF-51, "Reviewer/Proposal File and Associated Records.” Submission of the information is voluntary. Failure to provide full and complete information, however, may reduce the possibility of receiving an award.

An agency may not conduct or sponsor, and a person is not required to respond to, an information collection unless it displays a valid Office of Management and Budget (OMB) control number. The OMB control number for this collection is 3145-0058. Public reporting burden for this collection of information is estimated to average 120 hours per response, including the time for reviewing instructions. Send comments regarding the burden estimate and any other aspect of this collection of information, including suggestions for reducing this burden, to:

Suzanne H. Plimpton
Reports Clearance Officer
Policy Office, Division of Institution and Award Support
Office of Budget, Finance, and Award Managementl
National Science Foundation
Alexandria, VA 22314