NSF Org:	CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
Recipient:	UNIVERSITY OF CALIFORNIA SAN DIEGO
Initial Amendment Date:	August 6, 1998
Latest Amendment Date:	May 26, 2000
Award Number:	9730782
Award Instrument:	Continuing Grant
Program Manager:	Fred G. Heineken CBET  Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG  Directorate for Engineering
Start Date:	August 15, 1998
End Date:	July 31, 2002 (Estimated)
Total Intended Award Amount:	$400,622.00
Total Awarded Amount to Date:	$405,622.00
Funds Obligated to Date:	FY 1998 = $145,528.00 FY 1999 = $132,209.00 FY 2000 = $127,885.00
History of Investigator:	Michael Latz (Principal Investigator) mlatz@ucsd.edu John Frangos (Co-Principal Investigator)
Recipient Sponsored Research Office:	University of California-San Diego Scripps Inst of Oceanography 8622 DISCOVERY WAY # 116 LA JOLLA CA  US  92093-1500 (858)534-1293
Sponsor Congressional District:	50
Primary Place of Performance:	University of California-San Diego Scripps Inst of Oceanography 8622 DISCOVERY WAY # 116 LA JOLLA CA  US  92093-1500
Primary Place of Performance Congressional District:	50
Unique Entity Identifier (UEI):	QJ8HMDK7MRM3
Parent UEI:	QJ8HMDK7MRM3
NSF Program(s):	Cellular & Biochem Engineering
Primary Program Source:	app-0100  app-0198  app-0199
Program Reference Code(s):	9181, 9251, BIOT
Program Element Code(s):	149100
Award Agency Code:	4900
Fund Agency Code:	4900
Assistance Listing Number(s):	47.041

ABSTRACT

9730782 Latz This interdisciplinary project is to examine the shear sensitivity of marine dinoflagellates, one of the most shear-sensitive organisms known. Luminescent dinoflagellates respond essentially instantaneously to mechanical stimulation via a unique and easily monitored bioluminescent effector system. These plant-like cells will be used as a model system for investigating fundamental questions in sensory biology with important engineering applications. The main questions relating to the mechanosensory signal transduction pathway are: (1) what is the role of G proteins in signal transduction; (2) how is applied mechanical stress related to fluid shear stress and cell strain; and (3) how is shear sensitivity affected by the cytoskeleton? ***

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