NSF Org:	CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
Recipient:	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA
Initial Amendment Date:	September 10, 1997
Latest Amendment Date:	April 20, 2000
Award Number:	9709670
Award Instrument:	Standard Grant
Program Manager:	Thomas W. Chapman CBET  Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG  Directorate for Engineering
Start Date:	October 1, 1997
End Date:	September 30, 2001 (Estimated)
Total Intended Award Amount:	$160,000.00
Total Awarded Amount to Date:	$170,000.00
Funds Obligated to Date:	FY 1997 = $160,000.00 FY 1999 = $5,000.00 FY 2000 = $5,000.00
History of Investigator:	Giorgio Carta (Principal Investigator) gc@virginia.edu
Recipient Sponsored Research Office:	University of Virginia Main Campus 1001 EMMET ST N CHARLOTTESVILLE VA  US  22903-4833 (434)924-4270
Sponsor Congressional District:	05
Primary Place of Performance:	University of Virginia Main Campus 1001 EMMET ST N CHARLOTTESVILLE VA  US  22903-4833
Primary Place of Performance Congressional District:	05
Unique Entity Identifier (UEI):	JJG6HU8PA4S5
Parent UEI:
NSF Program(s):	Interfacial Engineering Progra
Primary Program Source:	app-0100  app-0197  app-0199
Program Reference Code(s):	0000, 9181, 9231, OTHR
Program Element Code(s):	141700
Award Agency Code:	4900
Fund Agency Code:	4900
Assistance Listing Number(s):	47.041

ABSTRACT

Abstract Proposal No: 9709670 Proposal Type: Investigator Initiated Principal Investigator: Giorgio Carta Affiliation: University of Virginia This grant is awarded through the Separations and Purification Program sub-element of the Interfacial, Transport and Separations Program of the Chemical and Transport Systems Division. The principal investigator is Dr. Giorgio Carta of the University of Virginia. The research is concerned with the characterization of diffusional transport of proteins and other macromolecules in gel-composite ion-exchangers and with the use of these materials in protein chromatography. The materials are obtained by synthesizing functionalized polymer gels within the pores of a rigid support matrix such that an essentially complete filling of the pores is achieved. The gel is thus stable to mechanical forces and to changes in solution conditions, allowing chromatographic operations at elevated flow rates of the mobile phase. This research addresses the development of new technologies for process scale protein chromatography. The fundamental understanding of protein transport in gels will aid development of new protein separation technologies, especially those oriented to high volume rapid separations.

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