NSF Org:	CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
Recipient:	UNIVERSITY OF MARYLAND BALTIMORE COUNTY
Initial Amendment Date:	May 23, 1997
Latest Amendment Date:	May 25, 2001
Award Number:	9702985
Award Instrument:	Continuing Grant
Program Manager:	Michael M. Domach CBET  Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG  Directorate for Engineering
Start Date:	June 1, 1997
End Date:	May 31, 2002 (Estimated)
Total Intended Award Amount:	$200,000.00
Total Awarded Amount to Date:	$230,000.00
Funds Obligated to Date:	FY 1997 = $50,000.00 FY 1998 = $60,000.00 FY 1999 = $50,000.00 FY 2000 = $50,000.00 FY 2001 = $20,000.00
History of Investigator:	Julia Ross (Principal Investigator) rjulie@vt.edu
Recipient Sponsored Research Office:	University of Maryland Baltimore County 1000 HILLTOP CIR BALTIMORE MD  US  21250-0001 (410)455-3140
Sponsor Congressional District:	07
Primary Place of Performance:	University of Maryland Baltimore County 1000 HILLTOP CIR BALTIMORE MD  US  21250-0001
Primary Place of Performance Congressional District:	07
Unique Entity Identifier (UEI):	RNKYWXURFRL5
Parent UEI:
NSF Program(s):	Cellular & Biochem Engineering
Primary Program Source:	app-0100  01000102DB NSF RESEARCH & RELATED ACTIVIT app-0197  app-0198  app-0199
Program Reference Code(s):	1045, 1359, 9120, 9181, 9231, BIOT
Program Element Code(s):	149100
Award Agency Code:	4900
Fund Agency Code:	4900
Assistance Listing Number(s):	47.041

ABSTRACT

9702985 Ross The research portion this proposal is directed toward an understanding of the cell adhesion process between bacterial cells and collagen extracellular matrices. The ultimate goal is to better understand the bacterial disease initiation process. The PI's hypothesis is that the ability of S. sureus to adhere to collagen under physiological flow conditions is directly related to the number of collagen receptors on the bacteria. Thus, the number of collagen receptors will be determined, the cell adhesion measured, and the correlation tested. The impact of fluid shear on receptor expression will also be determined. The educational plan centers around increasing the participation of women in the engineering profession. Academically talented young women will be coached from high school through their undergraduate engineering training. Research opportunities will be developed for juniors and seniors. ***

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