NSF Org:	IOS Division Of Integrative Organismal Systems
Recipient:	THE LELAND STANFORD JUNIOR UNIVERSITY
Initial Amendment Date:	July 18, 1996
Latest Amendment Date:	March 6, 1998
Award Number:	9631511
Award Instrument:	Continuing Grant
Program Manager:	Sonya K. Sobrian IOS  Division Of Integrative Organismal Systems BIO  Directorate for Biological Sciences
Start Date:	August 15, 1996
End Date:	July 31, 2000 (Estimated)
Total Intended Award Amount:	$214,900.00
Total Awarded Amount to Date:	$214,900.00
Funds Obligated to Date:	FY 1996 = $79,339.00 FY 1997 = $69,221.00 FY 1998 = $66,340.00
History of Investigator:	William Gilly (Principal Investigator) lignje@stanford.edu
Recipient Sponsored Research Office:	Stanford University 450 JANE STANFORD WAY STANFORD CA  US  94305-2004 (650)723-2300
Sponsor Congressional District:	16
Primary Place of Performance:	Stanford University Hopkins Marine Station Galvez House Pacific Grove CA  US  93950
Primary Place of Performance Congressional District:	19
Unique Entity Identifier (UEI):	HJD6G4D6TJY5
Parent UEI:
NSF Program(s):	BEHAVIORAL NEUROSCIENCE
Primary Program Source:	app-0196  app-0197  app-0198
Program Reference Code(s):	1096, 9107, 9178, 9251, BIOT, SMET
Program Element Code(s):	119100
Award Agency Code:	4900
Fund Agency Code:	4900
Assistance Listing Number(s):	47.074

ABSTRACT

9631511 Gilly Research on the giant axon system of the squid during the past 50 years has provided the foundation for our understanding of communication within and between neurons - nerve impulse conduction and synaptic transmission. The basic mechanisms governing these processes are shared by all organisms with nervous systems, from jellyfish to humans. Much remains to be learned about the dynamic interactions that occur between individual nerve and muscle cells and how these interactions change during the acquisition of new behaviors. Background work indicates that giant and non- giant motor systems in squid can act independently to achieve a large range of jet velocities or, in close concert, to achieve super-charged jetting. Experiments funded by this grant are designed to examine the interactions between these two motor systems during escape behavior and to describe changes in these interactions that occur shortly after hatching. Preliminary work has shown that these developmental changes are strongly linked to the experience-dependent acquisition of prey capture behavior. It is expected that this work will provide new insights into how activity of specific motor nerve cells is coordinated by the brain to produce complex behavioral outputs and how development of this motor coordination is influenced by experiences early in life.

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