| NSF Org: |
MCB Division of Molecular and Cellular Biosciences |
| Recipient: |
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| Initial Amendment Date: | June 6, 1995 |
| Latest Amendment Date: | June 6, 1995 |
| Award Number: | 9509105 |
| Award Instrument: | Standard Grant |
| Program Manager: |
Barbara K. Zain
MCB Division of Molecular and Cellular Biosciences BIO Directorate for Biological Sciences |
| Start Date: | June 15, 1995 |
| End Date: | May 31, 1996 (Estimated) |
| Total Intended Award Amount: | $18,000.00 |
| Total Awarded Amount to Date: | $18,000.00 |
| Funds Obligated to Date: |
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| History of Investigator: |
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| Recipient Sponsored Research Office: |
1600 KEN THOMPSON PKWY SARASOTA FL US 34236-1004 (941)388-4441 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
1600 KEN THOMPSON PKWY SARASOTA FL US 34236-1004 |
| Primary Place of
Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): | SIGNAL TRANSDCTN/CELL REGULATN |
| Primary Program Source: |
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| Program Reference Code(s): |
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| Program Element Code(s): |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.074 |
ABSTRACT
MCB 9509105 Catherine Walsh This proposal is designed to provide valuable preliminary data contributing to the long-term goal of characterizing thymic function in cartilaginous fish, the most primitive groups of jawed vertebrates to possess a distinct thymus. The work focuses on the preliminary characterization of possible phylogenetic equivalents of specialized cells identified in mammalian thymi as thymic nurse cells. The thymic nurse cells are suspected to have roles in interthymic T-cell maturation and/or removal of nonfunctional or self reactive thymocytes. The research planning grant will be used to develop a full research proposal to characterize the functional role and evolutionary significance of elasmobranch thymic cells. %%% This project will investigate the evolution of the thymus and the interrelation of cells in the thymus. It will provide evidence to explain how cells acquire different functions in the body of an organism. ***
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