NSF Org:	IOS Division Of Integrative Organismal Systems
Recipient:	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Initial Amendment Date:	August 17, 1994
Latest Amendment Date:	August 17, 1994
Award Number:	9409202
Award Instrument:	Continuing Grant
Program Manager:	Raymon Glantz IOS  Division Of Integrative Organismal Systems BIO  Directorate for Biological Sciences
Start Date:	August 15, 1994
End Date:	July 31, 1996 (Estimated)
Total Intended Award Amount:	$188,084.00
Total Awarded Amount to Date:	$65,890.00
Funds Obligated to Date:	FY 1994 = $65,890.00
History of Investigator:	Xiao-Jing Wang (Principal Investigator) xjwang@nyu.edu
Recipient Sponsored Research Office:	University of Pittsburgh 4200 FIFTH AVENUE PITTSBURGH PA  US  15260-0001 (412)624-7400
Sponsor Congressional District:	12
Primary Place of Performance:	University of Pittsburgh 4200 FIFTH AVENUE PITTSBURGH PA  US  15260-0001
Primary Place of Performance Congressional District:	12
Unique Entity Identifier (UEI):	MKAGLD59JRL1
Parent UEI:
NSF Program(s):	COMPUTATIONAL BIOLOGY ACTIVITI, COMPUTATIONAL NEUROSCIENCE, APPLIED MATHEMATICS
Primary Program Source:	app-0194  app-0195  app-0196
Program Reference Code(s):	9215, 9216, HPCC
Program Element Code(s):	110700, 116200, 126600
Award Agency Code:	4900
Fund Agency Code:	4900
Assistance Listing Number(s):	47.074

ABSTRACT

9409202 Wang Several different types of rhythmic oscillations can be recorded from the surface of the brain during different behaviors, particularly during different stages of sleep. Oscillations of about 7-14 Hz occur during early stages of sleep and slower oscillations of 0.5-5 Hz occur during later stages of sleep. It is known that the 7-14 Hz oscillations arises from the thalamus and there is some evidence that the slower oscillation may also be a thalamic oscillation. However, it is not known exactly how the neurons of the thalamus produce these oscillations. In this study from a young physicist, mathematical and computational modelling studies of these rhythmic oscillations will be carried out. The role of connections between the thalamus and cortex and the role of properties of individual thalamic nerve cells in the production of these oscillations will be examined. These theoretical studies should provide insights into the original of these oscillations as well as those that occur in the brain during sensory perception and those associated with other behaviors.

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