NSF Org:	CHE Division Of Chemistry
Recipient:	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA
Initial Amendment Date:	July 17, 1992
Latest Amendment Date:	April 13, 1994
Award Number:	9212008
Award Instrument:	Continuing Grant
Program Manager:	Kenneth M. Doxsee CHE  Division Of Chemistry MPS  Directorate for Mathematical and Physical Sciences
Start Date:	July 15, 1992
End Date:	June 30, 1996 (Estimated)
Total Intended Award Amount:	$244,600.00
Total Awarded Amount to Date:	$244,600.00
Funds Obligated to Date:	FY 1992 = $74,200.00 FY 1993 = $74,200.00 FY 1994 = $96,200.00
History of Investigator:	Walter Harman (Principal Investigator) wdh5z@virginia.edu
Recipient Sponsored Research Office:	University of Virginia Main Campus 1001 EMMET ST N CHARLOTTESVILLE VA  US  22903-4833 (434)924-4270
Sponsor Congressional District:	05
Primary Place of Performance:	University of Virginia Main Campus 1001 EMMET ST N CHARLOTTESVILLE VA  US  22903-4833
Primary Place of Performance Congressional District:	05
Unique Entity Identifier (UEI):	JJG6HU8PA4S5
Parent UEI:
NSF Program(s):	SYNTHESIS
Primary Program Source:	app-0193  app-0194
Program Reference Code(s):	0000, 9146, MANU, OTHR
Program Element Code(s):	194800
Award Agency Code:	4900
Fund Agency Code:	4900
Assistance Listing Number(s):	47.049

ABSTRACT

Coordinated arenes can serve as valuable synthons to a variety of mono-and polycyclic natural products when used in conjunction with an appropriate dihapto-coordination agent. In order to test and develop this hypothesis, the research program will address three primary questions: i) what organic transformations can be accomplished through such a technology that are difficult to achieve by conventional methods, ii) to what extent can the stereochemistry of such transformations be controlled by the transition metal, and iii) how can the nature of the complexing agent be modified to achieve a) greater activation of the aromatic substrate b) asymmetric induction, and c) a catalytic cycle for various target reactions? %%% With this award, the Organic Synthesis Program will support the research of Dr. W. Dean Harman at the University of Virginia. The research will develop the reactions of coordinated arene transition metal complexes to form substituted cyclic products which has the effect of shortening certain synthetic sequences. This new synthetic methodology should benefit research in biochemistry and medicine as well as in the chemical industry.

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