Award Abstract # 2243416
REU Site: Comparative Animal Model Approaches to Regeneration and Aging

NSF Org: DBI
Division of Biological Infrastructure
Recipient: THE MOUNT DESERT ISLAND BIOLOGICAL LABORATORY
Initial Amendment Date: March 10, 2023
Latest Amendment Date: January 9, 2024
Award Number: 2243416
Award Instrument: Continuing Grant
Program Manager: Deana Erdner
derdner@nsf.gov
 (703)292-2053
DBI
 Division of Biological Infrastructure
BIO
 Directorate for Biological Sciences
Start Date: April 1, 2023
End Date: March 31, 2026 (Estimated)
Total Intended Award Amount: $409,741.00
Total Awarded Amount to Date: $271,000.00
Funds Obligated to Date: FY 2023 = $135,401.00
FY 2024 = $135,599.00
History of Investigator:
  • Dustin Updike (Principal Investigator)
    dupdike@mdibl.org
  • Jane Disney (Co-Principal Investigator)
Recipient Sponsored Research Office: Mount Desert Island Biological Laboratory
159 OLD BAR HARBOR RD
BAR HARBOR
ME  US  04609-7250
(207)288-3605
Sponsor Congressional District: 02
Primary Place of Performance: Mount Desert Island Biological Laboratory
159 OLD BAR HARBOR RD
BAR HARBOR
ME  US  04609-7250
Primary Place of Performance
Congressional District:
02
Unique Entity Identifier (UEI): U46RJM97ML83
Parent UEI:
NSF Program(s): RSCH EXPER FOR UNDERGRAD SITES
Primary Program Source: 01002324DB NSF RESEARCH & RELATED ACTIVIT
01002425DB NSF RESEARCH & RELATED ACTIVIT

01002526DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s): 9250
Program Element Code(s): 113900
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.074

ABSTRACT

This REU Site award to the Mount Desert Island Biological Laboratory (MDIBL), located in Bar Harbor, ME, will support the training of 10 students for 10 weeks during the summers of 2023-2025. It is anticipated that a total of 30 students, primarily from schools with limited research opportunities or from underrepresented groups, will be trained in the program. Students will be at all stages of their undergraduate studies, and special consideration will be given to applicants interested in microscopy and comparative animal model research on regeneration and aging. Students will learn how research is conducted, and many will present the results of their work at scientific conferences. Assessment of the program will be done through the online SALG URSSA tool. Students will be required to register in the NSF ETAP system (etap.nsf.gov) and tracked after the program to determine their career paths.

This REU program MDIBL will expose students to comparative animal model approaches used to understand the biology of regeneration and aging. Labs at this REU site are interested in how cells, tissues, organs, and limbs are repaired or replenished after injury or during the ordinary course of development and the mechanisms retained or reemployed to ensure an organism thrives once development is complete. To answer these questions, researchers at MDIBL use various animal models. These animals include zebrafish, killifish, axolotl, fruit flies (Drosophila), and nematodes (Caenorhabditis elegans), which can be used to compare the genetic similarities and differences in aging and regeneration strategies across species. Students will be fully integrated into the scientific culture of MDIBL through symposia, seminars, activities, responsible conduct of research training, and weekly career discussions. Students More information about the program is available in the NSF ETAP registration system and by visiting https://mdibl.org/education/student-fellowships/reu-summer-fellowships/, or by contacting the PI (Dr. Updike at dupdike@mdibl.org) or the co-PI (Dr. Disney at jdisney@mdibl.org).

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Min, Hyemin and Spaulding, Emily L and Sharp, Catherine S and Garg, Pankaj and Jeon, Esther and Miranda_Portillo, Lyn S and Lind, Noah A and Updike, Dustin L "A role for BYN-1/bystin in cellular uptake and clearance of residual bodies in the Caenorhabditis elegans germline" Development , v.151 , 2024 https://doi.org/10.1242/dev.202694 Citation Details

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