| NSF Org: |
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems |
| Recipient: |
|
| Initial Amendment Date: | September 7, 2021 |
| Latest Amendment Date: | September 16, 2024 |
| Award Number: | 2121110 |
| Award Instrument: | Continuing Grant |
| Program Manager: |
Ron Joslin
rjoslin@nsf.gov (703)292-7030 CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG Directorate for Engineering |
| Start Date: | October 1, 2021 |
| End Date: | September 30, 2027 (Estimated) |
| Total Intended Award Amount: | $2,160,000.00 |
| Total Awarded Amount to Date: | $2,160,000.00 |
| Funds Obligated to Date: |
FY 2023 = $1,239,773.00 FY 2024 = $200,227.00 |
| History of Investigator: |
|
| Recipient Sponsored Research Office: |
3112 LEE BUILDING COLLEGE PARK MD US 20742-5100 (301)405-6269 |
| Sponsor Congressional District: |
|
| Primary Place of Performance: |
3112 Lee Bldg 7809 Regents Dr College Park MD US 20742-1800 |
| Primary Place of
Performance Congressional District: |
|
| Unique Entity Identifier (UEI): |
|
| Parent UEI: |
|
| NSF Program(s): | GCR-Growing Convergence Resear |
| Primary Program Source: |
01002324DB NSF RESEARCH & RELATED ACTIVIT 01002425DB NSF RESEARCH & RELATED ACTIVIT |
| Program Reference Code(s): | |
| Program Element Code(s): |
|
| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.041, 47.083 |
ABSTRACT
This Growing Convergence Research project addresses the critical societal need to develop a lung-independent technique for providing respiratory support to patients with respiratory failure from disorders such as COVID-19. Extracorporeal membrane oxygenation (ECMO) is the only such technique currently available, but is an expensive and scarce resource with complications that preclude it as an option for many patients, even when it is available. This project will develop a ?third lung? technology that achieves lung-independent gas exchange by circulating oxygenated perfluorocarbon (PFC, a safe, inert liquid with extraordinary gas-dissolving properties) through the abdominal cavity. This is a convergent research project that integrates bioengineering and control theory with physiology to create a technology with the potential to save thousands of lives every year.
Preliminary research results supported with an NSF EAGER award demonstrate potentially life-saving degrees of oxygenation and CO2 clearance. This project will push the research boundaries in three specific directions: (i) the development of a multi-functional fiber-optic sensor capable of measuring dissolved gas concentrations in PFC, as well as PFC temperature and pressure; (ii) the use of both benchtop and animal experiments to further characterize and model the fundamental dynamics of ?third lung? gas exchange; and (iii) the development of novel robust multivariable control algorithms for the ?third lung?, facilitating its potential implementation as a routine adjunct in the treatment of patients with respiratory failure. This convergent research portfolio will bring together a diverse research team from the fields of biomedical engineering, sensing, automatic control, and medicine in pursuit of research with high potential societal impact.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
Note:
When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external
site maintained by the publisher. Some full text articles may not yet be available without a
charge during the embargo (administrative interval).
Some links on this page may take you to non-federal websites. Their policies may differ from
this site.
Please report errors in award information by writing to: awardsearch@nsf.gov.
