| NSF Org: |
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems |
| Recipient: |
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| Initial Amendment Date: | May 6, 2016 |
| Latest Amendment Date: | May 6, 2016 |
| Award Number: | 1605325 |
| Award Instrument: | Standard Grant |
| Program Manager: |
Aleksandr Simonian
asimonia@nsf.gov (703)292-2191 CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG Directorate for Engineering |
| Start Date: | June 1, 2016 |
| End Date: | August 31, 2020 (Estimated) |
| Total Intended Award Amount: | $324,832.00 |
| Total Awarded Amount to Date: | $324,832.00 |
| Funds Obligated to Date: |
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| History of Investigator: |
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| Recipient Sponsored Research Office: |
1320 SOUTH DIXIE HIGHWAY STE 650 CORAL GABLES FL US 33146-2919 (305)284-3924 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
we have not heard any update yet Coral Gables FL US 33146-2509 |
| Primary Place of
Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): | BIOSENS-Biosensing |
| Primary Program Source: |
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| Program Reference Code(s): |
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| Program Element Code(s): |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.041 |
ABSTRACT
PI: Kim, Sung Jin
Proposal Number: 1605325
The proposed research will develop a new sensors that can detect cancer biomarkers at high sensitivity and at low cost. The principle the sensor design is based on, a new transduction mechanism, may make it easier to use in practical application. The sensor can be modified for measuring other biological entities and can potentially have very broad impact in medical diagnostics, environmental measurements and food safety.
The proposed research focuses on a new transduction mechanisms and design of biosensing platform using hot electron energy transfer generated by localized surface plasmon resonance (LSPR). The proposed biosensor will utilize a LSPR-based hybrid plasmon device structure consisting of the combination of both metallic nanoparticles (NPs) and a field effect transistor (FET), thereby engendering highly sensitive label-free detection of biomolecular interactions. Plasmon FET does not require bulky optical readout instrumentation, while taking advantages of plasmon based sensing. Unique characteristics such as electrically isolated plasmonic sensing surface, on-chip optical-to-electrical conversion and two-color lock-in amplifier based sensing will ensure robust sensing, an excellent signal-to-noise ratio, and real-time detection of molecular interaction. This sensor design allows the reduction in size of sensing area beyond the diffraction limit of light. Thus, it has the potential to lower cost, highly sensitive and rapid detection of disease biomarkers. This proposed research will carry out: 1) development of plasmon-FET sensing platform on a glass substrate; 2) evaluation using spiked PBS and clinical samples; and 3) a multiplexed sensing demonstration using four different biomarkers for prostate cancer diagnosis. The intellectual merit of the proposed activity is mainly the exploration of a new promising LSPR device using efficient hot electron emission and amplification. Successful development will lead the multiplexed microchip based sensing technology for a point-of-care device and a lab-on-a-chip based sensor assay. During the course of the project innovative materials will be developed which a focus on nanotechnology in general and nanophotonics and LSPR in particular, as well as promotion of interdisciplinary research (engineering, biochemistry and clinical research) for the graduate students, and provide research opportunities for undergraduate students.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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PROJECT OUTCOMES REPORT
Disclaimer
This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.
The project aims to develop a new sensing device using a Nanophotonics technology, Localized Surface Plasmon Resonance (LSPR). The novel sensing mechanism uses a hybrid device structure to convert the biological interactions to an electrical signal. The sensing platform consists of a transistor and nanostructured gold particles. This hybrid system is an integrated structure as an all-in-one device (sensing structure and transducer). The optical technique using modulated light signal extract only a signal from molecular interactions under an extremely noisy environment. The successful completion of this project brought a Nanophotonics technology in the realm of biomedical applicability, ultimately allowing inexpensive diagnostic detection and impacting many areas of biomedical sensing platforms such as cancer diagnosis, virus detection, toxicity sensing, and drug screening.
Along with the fundamental studies of sensing mechanisms and underlying physics, we have successfully demonstrated an outstanding sensor performance with nanomolar sensitivity using various proteins. One of the significant achievements is the demonstration of disease marker detections using unprocessed whole blood. Due to lots of different substances in the blood and its color, it is extremely difficult to have robust sensing for the targeted molecules, especially for the optical sensors. But our plasmon FET sensing platform has a unique design that catches the signals from the only targeted molecular interactions. All these research outcomes have been published in journal papers and presented at various conferences, and the related intellectual property has been issued. Overall, we have published four peer-reviewed journal papers, one US patent (#US20180217138A1), one conference proceedings, and more than ten conference presentations. The US patent has been licensed to a startup company in the Miami area.
This project supported the training of four Ph.D. students and four undergraduate students. The project outcomes are used for a discussion at the PI’s current graduate-level course (Nanophotonics) and Summer Scholar Program for High School Students (Introduction to Electrical and Computer Engineering). And every year, the PI has hosted local K-12 students to give a short lecture on Nanotechnology with lab tours.
Last Modified: 12/23/2020
Modified by: Sung Jin Kim
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