| NSF Org: |
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems |
| Recipient: |
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| Initial Amendment Date: | January 5, 2015 |
| Latest Amendment Date: | January 5, 2015 |
| Award Number: | 1464736 |
| Award Instrument: | Standard Grant |
| Program Manager: |
Carol Lucas
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG Directorate for Engineering |
| Start Date: | January 1, 2015 |
| End Date: | December 31, 2015 (Estimated) |
| Total Intended Award Amount: | $26,511.00 |
| Total Awarded Amount to Date: | $26,511.00 |
| Funds Obligated to Date: |
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| History of Investigator: |
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| Recipient Sponsored Research Office: |
4400 VESTAL PKWY E BINGHAMTON NY US 13902 (607)777-6136 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
NY US 13902-6000 |
| Primary Place of
Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): | Engineering of Biomed Systems |
| Primary Program Source: |
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| Program Reference Code(s): |
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| Program Element Code(s): |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.041 |
ABSTRACT
PI: Mahler, Gretchen J.
Proposal Number: 1464736
Creation of highly organized multicellular tumor constructs could potentially revolutionize oncology and tissue engineering. The recent advances in additive biomanufacturing, oncology, tissue engineering, microfabrication, and materials science offers new opportunities for creating sophisticated and vascularized 3D tumor models in vitro by printing or depositing materials and cancer and its surrounding cells layer-by-layer precisely with the help of a high-precision robot. These lab-produced high order tumor tissues can be used as disease models for both pathophysiological studies and drug discovery. Here, the PI proposes an NSF-NIH joint Workshop in integrative advanced biomanufacturing and tumor engineering. The overarching goal of this workshop is to bring together scientific leaders to review the progress, to identify grand challenges in integrating additive manufacturing with tumor engineering, and finally to articulate a vision to advance physical sciences and engineering in life sciences and oncology. The emerging of additive biomanufacturing, human genome editing, stem cell engineering, material genome techniques, computational and synthetic biology, and personalized medicine offers new opportunities to spur research, education, industry growth and innovation in tumor engineering. The following objectives are expected to be achieved through the workshop: 1) Identify challenges in biomanufacturing of tumor models that express key characteristics of human tumors in vivo, 2) Develop a community to share ideas, resources, and technologies to address challenges identified through the workshop, 3) Establish a forum for engineers to collaborate with oncologists or vice versa in tumor engineering research, 4) Increase public awareness of tumor engineering research, 5) Promote tumor engineering research and education programs, and train and educate students in tumor engineering research.
The workshop will be held in Bethesda, MD, February 19-20, 2015. It will consist of panel presentations and in-depth discussions by leading scholars and researchers. The panel discussion will be led by a session chair and documented by a scribe. The scribe will be responsible for developing a session report based on the discussions. The session report will be further extended into a Workshop Report that will be published and accessible by the public. The workshop will tentatively consist of four sessions including "Tumor-on-A-Chip", "3D Printing of Multiple Tissues Integrated Physiological Tumor Models", "Noninvasive Characterization of 3D Printed Tumor Tissues", and "Multiscale Tumor Computational Modeling". While there have been increasingly more workshops and symposia in additive manufacturing held or planned lately, no workshops or symposia, to the best of organizers' knowledge, have significant overlap with the proposed workshop. It is expected that this workshop will initiate and stimulate the discussion on integrating additive biomanufacturing with tumor engineering and spur collaboration among engineers, oncologists, and life scientists. The findings of the Workshop will be disseminated in several different ways. The report will be published and accessible to the research community. A perspective paper stemmed from the Workshop will be published in a peer-review journal. The workshop will serve as an open forum for researchers and scholars to interact with each other and to exchange ideas. Efforts will be made to recruit early career investigators and investigators from underrepresented groups to participate in the workshop.
PROJECT OUTCOMES REPORT
Disclaimer
This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.
The recent advances in additive biomanufacturing, oncology, tissue engineering, microfabrication, and materials science offer new opportunities for creating sophisticated and vascularized 3D tumor models in vitro by printing or depositing materials and cancer cells layer-by-layer precisely with the help of a high-precision robot. These lab-produced high order tumor tissues can be used as disease models for both pathophysiological study and drug discovery.
The NCI-NSF Joint Workshop on Integrative Additive Biomanufacturing and Tumor Engineering was held on April 1-2, 2015 at the Porter Neuroscience Research Center (Bldg 35A, Room 620/630) on the NIH main campus in Bethesda, MD. It consisted of panel presentations and in-depth discussions by 35 leading investigators, junior investigators, and early career investigators and 21 government attendees. The workshop was focused on reviewing progress and identifying challenges and opportunities in integrative additive biomanufacturing and tumor engineering.
The workshop served as an open forum for researchers and scholars to interact with each other and to exchange ideas. Both early career investigators and investigators from underrepresented groups participated in the workshop and were able to interact with established leaders in their respective fields, in addition to working closely with program directors from government agencies. The specific objectives that were achieved through the workshop include: 1) Identifying challenges in additive biomanufacturing of tumor models; 2) developing a community to share ideas, resources, and technologies to address challenges identified through the workshop; 3) establishing a forum for engineers to collaborate with oncologists or vice versa in tumor engineering research; 4) increasing public awareness of tumor engineering research; 5) promoting tumor engineering research and education programs; and 6) training and educating students in tumor engineering research.
Creation of highly organized multicellular constructs, including tumors, will revolutionize tissue engineering, oncology, and drug screening. This workshop has initiated and stimulated the discussion on integrating additive biomanufacturing with tumor engineering and spurred collaboration opportunities among engineering, oncologists, and life scientists. A report was published and accessible to the research community. A white paper stemming from the report will be published in a peer-review journal as a perspective paper in order to further disseminate the key findings from the workshop. The conference presentations and discussions have been documented and stored on the conference website. They are accessible to the research community without any charge.
Last Modified: 01/22/2016
Modified by: Gretchen J Mahler
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