| NSF Org: |
CHE Division Of Chemistry |
| Recipient: |
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| Initial Amendment Date: | September 8, 2013 |
| Latest Amendment Date: | September 8, 2013 |
| Award Number: | 1310363 |
| Award Instrument: | Standard Grant |
| Program Manager: |
Kelsey Cook
CHE Division Of Chemistry MPS Directorate for Mathematical and Physical Sciences |
| Start Date: | September 15, 2013 |
| End Date: | February 28, 2017 (Estimated) |
| Total Intended Award Amount: | $460,000.00 |
| Total Awarded Amount to Date: | $460,000.00 |
| Funds Obligated to Date: |
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| History of Investigator: |
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| Recipient Sponsored Research Office: |
809 S MARSHFIELD AVE M/C 551 CHICAGO IL US 60612-4305 (312)996-2862 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
845 W Taylor St Chicago IL US 60607-7061 |
| Primary Place of
Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): | Chemical Measurement & Imaging |
| Primary Program Source: |
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| Program Reference Code(s): | |
| Program Element Code(s): |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.049 |
ABSTRACT
Nuclear magnetic resonance (NMR) spectroscopy is an indispensable tool for determining the structure of molecules. In this project, supported by the Chemical Measurement and Imaging Program of the Division of Chemistry, Prof. Yoshitaka Ishii of the University of Illinois at Chicago and his research group will establish a new framework of next-generation NMR spectroscopy for biomoleculces and materials in solids, which is generally called solid-state NMR (SSNMR). The proposed work would aim to increase the speeds of the data collection 50-6000 fold over a traditional method by integrating advanced methods such as 1H detection, novel isotope labeling, and paramagnetic doping into a non-traditional SSNMR approach using an ultra high magnetic field and very fast magic angle spinning. The second component of the research involves SSNMR analysis of peptides and proteins during solid-phase peptide synthesis, which reveals the structural changes of the protein during the reactions. The third component is to examine graphene/graphite based nano materials, in particular, chemical reactions of graphene oxide and graphite oxide and the interactions of H2O with porous grapheme-based systems.
Ishii's research will advance NMR technology applications to a broader range of insoluble proteins and non-crystalline materials, which cannot be analyzed by other tools such as x-ray crystallography. Advances in the Ishii group research will likely have impacts in the many venues of NMR based technology, including nanomaterials analysis and peptide science. Professor Ishii will integrate his research into his educational activities by establishing a new graduate course on solid-state NMR with hands-on experiments. Professor Ishii will also incorporate a demo of a simple magnetic resonance imaging (MRI) experiment into molecular diffusion experiments with NMR field gradient in undergraduate labs in order to discuss the connection of NMR with the MRI technology used for medical diagnostics. Finally, Professor Ishii will recruit undergraduate researchers through Summer Research Opportunities for Undergraduates Program (SROP) at the University of Illinois at Chicago, which emphasizes the diversity in research-based undergraduate education.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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PROJECT OUTCOMES REPORT
Disclaimer
This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.
This proposal targets two connected classes of systems: bio-macromolecules and nano-structured systems, the latter of which include nano-structured peptides/proteins and graphite/graphene-based materials. Through this project, we promoted the development of new solid-state NMR (SSNMR) frameworks to enhance sensitivity and to characterize atomic-level structures and chemical reactions for both biomolecules and nano-structured systems. Specifically, we established a framework of biomolecular SSNMR through achieving signal assignments and structural determination for a nanomol-scale quantity of proteins (1-30 nmol) by 2D-4D SSNMR with 9000 fold acceleration in data collection over traditional SSNMR. Our scope includes signal assignments and structural elucidation for larger proteins and protein assemblies such as amyloid fibrils that are associated with neurodegenerative diseases. We also established novel SSNMR-based methodologies for carbon materials, which include novel battery materials. SSNMR frameworks were established to capture the structural changes that occur during chemical modifications of graphite/graphene-based materials using chemical reductions of graphite oxide (GO) and graphene oxide modified by chemical reactions as attractive examples. Ab-initio calculations were effectively utilized to model the interactions of the probe molecules with graphene in various modes. Through this NSF-funded project, we also trained several graduate students and undergraduate students in hands-on projects involving cutting-edge science. Overall, the project generated excellent scientific outputs.
Last Modified: 07/23/2020
Modified by: Yoshitaka Ishii
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