| NSF Org: |
ECCS Division of Electrical, Communications and Cyber Systems |
| Recipient: |
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| Initial Amendment Date: | May 29, 2013 |
| Latest Amendment Date: | May 7, 2014 |
| Award Number: | 1303499 |
| Award Instrument: | Standard Grant |
| Program Manager: |
Shubhra Gangopadhyay
ECCS Division of Electrical, Communications and Cyber Systems ENG Directorate for Engineering |
| Start Date: | June 15, 2013 |
| End Date: | May 31, 2017 (Estimated) |
| Total Intended Award Amount: | $200,000.00 |
| Total Awarded Amount to Date: | $208,000.00 |
| Funds Obligated to Date: |
FY 2014 = $8,000.00 |
| History of Investigator: |
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| Recipient Sponsored Research Office: |
1109 GEDDES AVE STE 3300 ANN ARBOR MI US 48109-1015 (734)763-6438 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
1101 Beal Ave. Ann Arbor MI US 48109-2110 |
| Primary Place of
Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): | CCSS-Comms Circuits & Sens Sys |
| Primary Program Source: |
01001415DB NSF RESEARCH & RELATED ACTIVIT |
| Program Reference Code(s): |
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| Program Element Code(s): |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.041 |
ABSTRACT
The objective of the proposed collaborative research is to develop a plasmonically enhanced optical
ring resonator (PEORR) sensor array for unlabelled biomolecule detection at the single molecule level.
The proposed hybrid sensor synergizes microfabricated ring resonators and nanofabricated plasmonic
nanostructures. It takes advantage of the excellent sensing resolution associated with the ring resonator
and the tremendously enhanced sensitivity arising from the plasmonic nanostructures to achieve single
molecule detection, and of the carousel effect from the ring resonator for efficient capture and transport of
biomolecules for sample enrichment and expeditious detection.
Intellectual Merit: Detection and study of biomolecules at the single molecule level allow to probe and
characterize molecules in unprecedented detail. Traditional single molecule detection relies primarily on
fluorescence microscopy, which requires sophisticated instruments and complicated dye labeling
processes that may adversely affect a molecules functionality.
Broader Impact: The proposed project will be carried out synergistically by the terms from the University
of Michigan and the Polytechnic Institute at New York University. Graduate students will be
trained in interdisciplinary science and will work in each of the two labs through an exchange program.
Undergraduate students will be paired with graduate students to obtain hands-on experience. Videos on
Youtube will be jointly created to publicize the research findings. Finally, the PI will work with local non-
Ph.D. granting colleges to develop a summer program for their students to conduct research in the PI's
lab at the University of Michigan.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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PROJECT OUTCOMES REPORT
Disclaimer
This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.
The objective of the proposed collaborative research is to develop a plasmonically enhanced optical ring resonator sensor (PEORR) for unlabelled biomolecule detection at the single molecule level. The proposed hybrid sensor synergizes microfabricated ring resonators and nanofabricated plasmonic nanostructures. It takes advantage of the excellent sensing resolution associated with the ring resonator and the tremendously enhanced sensitivity arising from the plasmonic nanostructures to achieve single molecule detection, and of the carousel effect from the ring resonator for efficient capture and transport of biomolecules for sample enrichment and expeditious detection.
In the project, the researchers investigated the PEORR both theoretically and experimentally. The findings are summarized as follows.
1. Precision nanoparticle sizing can be achieved by monitoring the spectral shift of the different azimuthal modes of the whispering gallery mode.
2. Nanoparticles (such as plasmonic nanoparticles) can be attached to the ring resonator surface with precise control of the particle location through a method called “light force assembly”.
3. Nanoparticle sizing can be significantly improved by considering the large field gradients associated with the evanescent decay of a whispering gallery mode.
4. A novel optofluidic ring resonator (stand-alone or coupled ring resonator) can be precisely fabricated using femto-second laser inscription (or standard photolithographic method).
5. A side waveguide can be created adjacent to the optofluidic ring resonator using femto-second laser inscription. The coupling between the optofluidic ring resonator is theoretically analyzed and calculated, and experimentally demonstrated. It is shown the ring resonator has a Q-factor of 10^4 – 10^5.
The above outcomes were disseminated via a number of peer-reviewed journal articles, conference presentations, book chapters, and seminars. In addition, quite a few post-doctors, graduate and undergraduate students were trained.
Last Modified: 08/01/2017
Modified by: Xudong Fan
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