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Award Abstract # 0946690
Acquisition of a Low-Field NMR Spectrometer for Research and Teaching

NSF Org: CHE
Division Of Chemistry
Recipient: UNIVERSITY OF NEW MEXICO
Initial Amendment Date: January 14, 2010
Latest Amendment Date: January 14, 2010
Award Number: 0946690
Award Instrument: Standard Grant
Program Manager: Carlos Murillo
CHE
 Division Of Chemistry
MPS
 Directorate for Mathematical and Physical Sciences
Start Date: January 15, 2010
End Date: December 31, 2012 (Estimated)
Total Intended Award Amount: $193,700.00
Total Awarded Amount to Date: $193,700.00
Funds Obligated to Date: FY 2010 = $193,700.00
History of Investigator:
  • Martin Kirk (Principal Investigator)
    mkirk@unm.edu
  • Patrick Mariano (Co-Principal Investigator)
  • Robert Paine (Co-Principal Investigator)
  • Richard Kemp (Co-Principal Investigator)
  • Wei Wang (Co-Principal Investigator)
Recipient Sponsored Research Office: University of New Mexico
1 UNIVERSITY OF NEW MEXICO
ALBUQUERQUE
NM  US  87131-0001
(505)277-4186
Sponsor Congressional District: 01
Primary Place of Performance: University of New Mexico
1 UNIVERSITY OF NEW MEXICO
ALBUQUERQUE
NM  US  87131-0001
Primary Place of Performance
Congressional District:
01
Unique Entity Identifier (UEI): F6XLTRUQJEN4
Parent UEI:
NSF Program(s): Chemical Instrumentation
Primary Program Source: 01001011DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s): 0000, 1108, 1401, 9150, 9161, OTHR
Program Element Code(s): 193800
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.049

ABSTRACT

With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation program (CRIF:MU), Professors Martin L. Kirk, Richard Kemp, Patrick S. Mariano, Robert T. Paine and Wei Wang from the Department of Chemistry and Chemical Biology at the University of New Mexico will acquire a low-field (300 MHz) multinuclear NMR spectrometer. The instrument will be used to support research activities such as: 1) synthetic methodologies that allow for step by-step (atom-by-atom) assembly of new families of main group element ring and polycyclic cage compounds rich in Group 13, 14 and 15 elements; 2) activation and fixing of small molecules such as carbon dioxide, COS, carbon disulfide, and oxygen to produce more valuable products; 3) homogeneous catalytic routes to epoxides and other partially-oxidized organics using late transition metal pincer complexes; 4) characterization of structures and stereochemistry of synthetic intermediates and natural and non-natural products; 5) rational design of Giardia lamblia growth inhibitors as well as study of phosphoproteins; 6) study of donor-bridge-acceptor systems as potential components of molecular wire devices and, 7) synthesis of new inhibitors of the proteins cholesterol esterase, lactate dehydrogenase, NfKB, urokinase, aldose reductase, HIV protease and Abeta aggregates.

Multinuclear NMR spectroscopy is an essential analytical tool in chemistry and biochemistry research. The spectra enable researchers to identify unknown substances and to provide information on the atom arrangement and structures in species ranging from small molecules to large proteins by detecting transitions between energy levels arising from the nuclear spin properties of atoms. This spectrometer will enhance many research activities of investigators and students, many of whom are from underrepresented groups.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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(Showing: 1 - 10 of 43)
B.M. Barry, D.A. Dickie, A.E. Wetherby Jr., W.E. Barker IV, C.A. Larsen, R. Waterman, W.E. Geiger, and R.A. Kemp "CO2 Interactions with Main Group Compounds Directed Towards Preparing Useful Organic Compounds" Prepr. Pap. - Am. Chem. Soc. - Fuel Chem. , v.57 , 2012 , p.294
Camus, Jean-Michel; Pailloux, Sylvie; Shirima, Cornel Edicome; Paine, Robert T. "Synthesis of 2,5-bis(phosphinoylmethyl)- and 2,5-bis(thiophosphinoylmethyl)-thiophenes" MAIN GROUP CHEMISTRY , v.10 , 2011 , p.25-36
Chakravarty, Manab; Pailloux, Sylvie; Ouizem, S.; Smith, K. A.; Duesler, Eileen N.; Paine, Robert T.; Williams, Neil J.; Hancock, Robert D. "Synthesis and metal coordination chemistry of (phenyl)(pyridin-2-ylmethyl)phosphinodithioic acid, [2-C5H4N]CH2P(S)(SH)(Ph)" POLYHEDRON , v.33 , 2012 , p.327-335
Chen, Tuqiang; Duesler, Eileen N.; Noeth, Heinrich; Evangelisti, C.; Paine, Robert T. "Synthesis and reactivity of a zirconocene bis-(aminoborylphosphane)" MAIN GROUP CHEMISTRY , v.10 , 2011 , p.279-291
Cho, Dae Won; Latham, John A.; Park, Hea Jung; Yoon, Ung Chan; Langan, Paul; Dunaway-Mariano, Debra; Mariano, Patrick S. "Regioselectivity of Enzymatic and Photochemical Single Electron Transfer Promoted Carbon-Carbon Bond Fragmentation Reactions of Tetrameric Lignin Model Compounds" JOURNAL OF ORGANIC CHEMISTRY , v.76 , 2011 , p.2840-2852
Cho, Dae Won; Lee, Chan Woo; Park, Jong Gu; Oh, Sun Wha; Sung, Nam Kyoung; Park, Hea Jung; Kim, Kyung Mok; Mariano, Patrick S.; Yoon, Ung Chan "Exploration of photochemical reactions of N-trimethylsilylmethyl-substituted uracil, pyridone, and pyrrolidone derivatives" PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES , v.10 , 2011 , p.1169-1180
Cho, Dae Won; Lee, Hyang-Yeol; Oh, Sun Wha; Choi, Jung Hei; Park, Hea Jung; Mariano, Patrick S.; Yoon, Ung Chan "Photoaddition reactions of 1,2-diketones with silyl ketene acetals. Formation of beta-hydroxy-gamma-ketoesters" JOURNAL OF ORGANIC CHEMISTRY , v.73 , 2008 , p.4539-4547
Cho, Dae Won; Quan, Chunsheng; Park, Hea Jung; Choi, Jung Hei; Kim, Su Rhan; Hyung, Tae Gyung; Yoon, Ung Chan; Kim, Sung Hong; Jin, Ying Xue; Mariano, Patrick S. "Studies aimed at elucidating factors involved in the control of chemoselectivity in single electron transfer promoted photoreactions of branched-polydonor substituted phthalimides" TETRAHEDRON , v.66 , 2010 , p.3173-3186
Cho, Dae Won; Yoon, Ung Chan; Mariano, Patrick S. "Studies Leading to the Development of a Single-Electron Transfer (SET) Photochemical Strategy for Syntheses of Macrocyclic Polyethers, Polythioethers, and Polyamides" ACCOUNTS OF CHEMICAL RESEARCH , v.44 , 2011 , p.204-215
Cho, DW; Latham, JA; Park, HJ; Yoon, UC; Langan, P; Dunaway-Mariano, D; Mariano, PS "Regioselectivity of Enzymatic and Photochemical Single Electron Transfer Promoted Carbon-Carbon Bond Fragmentation Reactions of Tetrameric Lignin Model Compounds" JOURNAL OF ORGANIC CHEMISTRY , v.76 , 2011 , p.2840 View record at Web of Science 10.1021/jo200253
Cho, DW; Parthasarathi, R; Pimentel, AS; Maestas, GD; Park, HJ; Yoon, UC; Dunaway-Mariano, D; Gnanakaran, S; Langan, P; Mariano, PS "Nature and Kinetic Analysis of Carbon-Carbon Bond Fragmentation Reactions of Cation Radicals Derived from SET-Oxidation of Lignin Model Compounds" JOURNAL OF ORGANIC CHEMISTRY , v.75 , 2010 , p.6549 View record at Web of Science 10.1021/jo101250
(Showing: 1 - 10 of 43)

PROJECT OUTCOMES REPORT

Disclaimer

This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.

Nature of the Project:

Nuclear Magnetic Resonance (NMR) spectroscopy uses a combination of magnetic fields and radio waves to obtain vital information regarding the chemical structure and dynamics of molecules.  NMR is an extremely powerful analytical tool in modern chemical research and is crucial to the vitality of graduate and undergraduate programs in chemistry.

 The Chemistry and Chemical Biology Department at The University of New Mexico has developed concentrated research foci in biological chemistry and materials chemistry, in addition to maintaining teaching and research efforts in the traditional areas of chemistry.  Synthetic organic and inorganic chemistry play significant roles in our Department.  Therefore the characterization of chemical compounds by NMR is extremely important, and numerous researchers in our Department have greatly benefited from the purchase of this new NMR spectrometer.

Outcomes and Findings:

Intellectual Merit

The final outcomes and findings of the project have already been or will be broadly disseminated in the scientific literature and at a variety of scientific meetings and conferences.  Examples of key outcomes and findings resulting from the funded project include using the NMR instrument to: 1) characterize compounds designed to recycle carbon dioxide into transportation fuels and useful chemicals, 2) support research endeavors directed toward the preparation of new materials for more efficient organic photovoltaics, 3) characterize new molecules and enzyme models that have contributed to our increased understanding of enzyme mechanism and structure as they relate to enzyme function and disease states, 4) characterize new molecules that have increased our understanding of molecular electron transfer and transport (molecular electronics), and electronics that utilize the spin of the electron (spintronics), 5) elucidate interface structure and interactions in charge transfer complexes of donor/acceptor conjugated materials used in next generation organic solar cells, 6) support efforts to develop advanced materials used for selective and efficient recovery of strategic and rare materials from harsh environments, 7) aid in the development and understanding of new chemical reactions and their utility in preparing biochemically active and potentially medicinally significant substances, 8) develop a novel miRNA regulating strategy that will have broad impact for all biological research fields involving miRNA studies, and 9) elucidate structures of novel natural products that are potential drugs, drug leads, or cellular probes.

Broader Impacts

 The University of New Mexico is a majority-minority institution.  Our undergraduate chemistry program has a high percentage of minority and other traditionally under-represented groups, and both undergraduate and high-school students have benefitted from this instrumentation. We feel that our students should have a hands-on experience with state of the art instrumentation since chemistry is an experimental science. It is through experimentation that new knowledge is generated, and it is through experimentation that students are challenged and the learning process is solidified. Because of this, the Department has encouraged undergraduates to participate in research, and the majority of undergraduate chemistry majors do participate in undergraduate research. Undergraduate students performing research routinely obtain the necessary training to acquire and process their own NMR spectra.

All of the research projects listed above included graduate and postdoctoral students.  Most included undergraduate researchers and several included h...

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