Award Abstract # 0938158
Development of a 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

NSF Org: CHE
Division Of Chemistry
Recipient: FLORIDA STATE UNIVERSITY
Initial Amendment Date: December 5, 2009
Latest Amendment Date: June 8, 2015
Award Number: 0938158
Award Instrument: Cooperative Agreement
Program Manager: Colby Foss
cfoss@nsf.gov
 (703)292-5327
CHE
 Division Of Chemistry
MPS
 Directorate for Mathematical and Physical Sciences
Start Date: December 1, 2009
End Date: September 30, 2015 (Estimated)
Total Intended Award Amount: $0.00
Total Awarded Amount to Date: $0.00
Funds Obligated to Date: FY 2010 = $1.00
History of Investigator:
  • Alan Marshall (Principal Investigator)
    marshall@magnet.fsu.edu
Recipient Sponsored Research Office: Florida State University
874 TRADITIONS WAY
TALLAHASSEE
FL  US  32306-0001
(850)644-5260
Sponsor Congressional District: 02
Primary Place of Performance: Florida State University
874 TRADITIONS WAY
TALLAHASSEE
FL  US  32306-0001
Primary Place of Performance
Congressional District:
02
Unique Entity Identifier (UEI): JF2BLNN4PJC3
Parent UEI:
NSF Program(s): Chemical Instrumentation
Primary Program Source: 01001011DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s): 0000, OTHR
Program Element Code(s): 193800
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.049

ABSTRACT

DMR-0938158
PIs: Boebinger, Marshall


This award will fund the design, construction, and optimization of performance of a 21 Tesla ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometer(FTICR-MS). The rationale for this project draws from the workshop, "Science Challenges and Design Concepts for the Next-Generation High-Performance FT-ICR Mass Spectrometer," organized jointly by National High Magnetic Field Laboratory (NHMFL) and the Environmental Molecular Scienes Laboratory (EMSL), and held on 16-17 January, 2008 at NHMFL. Feasibility of the magnet design has been demonstrated by NHMFL's Magnet Science and Technology group, and three vendors have offered to build it. The other components of the spectrometer will be designed and built by NHMFL permanent staff and two postdoctoral researchers. Ion optics design will be guided by large-scale supercomputer simulations (modeling the interaction of more than 1,000,000 ions). This project will improve every aspect of technical performance: sample introduction, ion source(s), ion transmission, ion external accumulation, ion cyclotron resonance (ICR) excitation and detection, computerized and automated instrument control, higher magnetic field, and data reduction. Magnet delivery will take three years, allowing for extensive progress in design of the rest of the instrument in the interim. Applications will focus on petroleomics, top-down proteomics, and hydrogen/deuterium exchange to map contact surfaces in biomacromolecular complexes.

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