| NSF Org: |
CHE Division Of Chemistry |
| Recipient: |
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| Initial Amendment Date: | August 30, 2009 |
| Latest Amendment Date: | August 30, 2009 |
| Award Number: | 0922712 |
| Award Instrument: | Standard Grant |
| Program Manager: |
Carlos Murillo
CHE Division Of Chemistry MPS Directorate for Mathematical and Physical Sciences |
| Start Date: | September 1, 2009 |
| End Date: | August 31, 2012 (Estimated) |
| Total Intended Award Amount: | $199,666.00 |
| Total Awarded Amount to Date: | $199,666.00 |
| Funds Obligated to Date: |
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| History of Investigator: |
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| Recipient Sponsored Research Office: |
730 SULLIVAN RD EASTON PA US 18042-1760 (610)330-5029 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
730 SULLIVAN RD EASTON PA US 18042-1760 |
| Primary Place of
Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): | Major Research Instrumentation |
| Primary Program Source: |
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| Program Reference Code(s): |
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| Program Element Code(s): |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.049 |
ABSTRACT
With this award from the Major Research Instrumentation (MRI) program, Yvonne M. Gindt and her colleagues H. David Husic, William H. Miles and Jennifer L. Rutherford at Lafayette College will acquire an isothermal titration calorimeter (ITC) and a stopped flow mixer and spectrometer. They will be used in a variety of projects including: 1) mapping the binding of UV-damaged DNA to photolyase and VcCry1, enzymes that repair DNA using blue-light; 2) measuring the kinetics of DNA binding to photolyase; 3) studies of carbonic anhydrase, an enzyme which enhances the efficiency for carbon dioxide utilization for photosynthesis; 4) measurement of the kinetics of the ring-chain tautomerism of gamma-hydroxybutenolides; and 5) measurement of the kinetics of two industrially important reactions, non-cryogenic lithiations and palladium-catalyzed cross-coupling reactions, to elucidate mechanistic details of the reactions.
Isothermal titration calorimetry is used to determine thermodynamic properties of chemical reactions, or of the binding of small molecules to other species by measuring temperature changes when substances are mixed (titrated). A stopped-flow apparatus is similarly used for rapid mixing and monitoring of subsequent changes using spectroscopic techniques to observe the progress of a reaction. These changes provide insight on the underlying microscopic processes that are occurring, such as the energy released in a reaction or the strength of the binding between two species or the speed of a reaction. The instruments will be used in research and laboratory classes by undergraduate students. The equipment will also strengthen existing collaborations between Lafayette College and Montclair State University with a substantial enrollment of underrepresented students.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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