NSF Org:	TI Translational Impacts
Recipient:
Initial Amendment Date:	May 22, 2007
Latest Amendment Date:	November 30, 2007
Award Number:	0712489
Award Instrument:	Standard Grant
Program Manager:	Gregory T. Baxter TI  Translational Impacts TIP  Directorate for Technology, Innovation, and Partnerships
Start Date:	July 1, 2007
End Date:	June 30, 2008 (Estimated)
Total Intended Award Amount:	$0.00
Total Awarded Amount to Date:	$150,000.00
Funds Obligated to Date:	FY 2007 = $100,000.00 FY 2008 = $50,000.00
History of Investigator:	Lisa Kemp (Principal Investigator) lisa.kemp@usm.edu
Recipient Sponsored Research Office:	Ablitech, Inc. PO Box 415 Hattiesburg MS  US  39403-0000 (601)467-9418
Sponsor Congressional District:
Primary Place of Performance:	Ablitech, Inc. PO Box 415 Hattiesburg MS  US  39403-0000
Primary Place of Performance Congressional District:
Unique Entity Identifier (UEI):
Parent UEI:
NSF Program(s):	SBIR Phase I
Primary Program Source:	app-0107  01000809DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s):	1491, 9102, 9150, 9183, BIOT
Program Element Code(s):	537100
Award Agency Code:	4900
Fund Agency Code:	4900
Assistance Listing Number(s):	47.084

ABSTRACT

This Small Business Innovation Research (SBIR) Phase I research research project aims to develop a polymer system for drug eluting coronary stents (DES). The material is expected to provide higher drug loading with a controlled drug release profile, as well as tunable mechanical properties over the lifetime of the stent. This will be accomplished using block terpolymers of specific composition to which drug molecules will be covalently attached.

Recent advances in DES technology have increased the success rate of CHD treatment; however, restenosis (re-blockage of the artery through the stent) occurs in 10% of the implanted stents. Also currently available drug eluting coatings deliver the bulk of the loaded drug within the first 48 hours of stent placement, with little to no delivery after 30 days. Thus a new type of stent that can overcome the limitations of current stents would be of significant value.

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