NSF Org:	CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
Recipient:	CARNEGIE MELLON UNIVERSITY
Initial Amendment Date:	June 22, 2007
Latest Amendment Date:	June 2, 2008
Award Number:	0708418
Award Instrument:	Standard Grant
Program Manager:	Leon Esterowitz CBET  Division of Chemical, Bioengineering, Environmental, and Transport Systems ENG  Directorate for Engineering
Start Date:	July 1, 2007
End Date:	June 30, 2009 (Estimated)
Total Intended Award Amount:	$0.00
Total Awarded Amount to Date:	$105,000.00
Funds Obligated to Date:	FY 2007 = $105,000.00
History of Investigator:	Kris Dahl (Principal Investigator) kndahl@andrew.cmu.edu Mohammad Islam (Co-Principal Investigator)
Recipient Sponsored Research Office:	Carnegie-Mellon University 5000 FORBES AVE PITTSBURGH PA  US  15213-3815 (412)268-8746
Sponsor Congressional District:	12
Primary Place of Performance:	Carnegie-Mellon University 5000 FORBES AVE PITTSBURGH PA  US  15213-3815
Primary Place of Performance Congressional District:	12
Unique Entity Identifier (UEI):	U3NKNFLNQ613
Parent UEI:	U3NKNFLNQ613
NSF Program(s):	NANOSCALE: EXPLORATORY RSRCH
Primary Program Source:	app-0107
Program Reference Code(s):	0000, 014E, 7236, OTHR
Program Element Code(s):	167600
Award Agency Code:	4900
Fund Agency Code:	4900
Assistance Listing Number(s):	47.041

ABSTRACT

0708418
Dahl
This proposed research will establish a relationship between subcellular reorganization and toxicological effects to incorporation of anisotropic molecules into cells. in light of conflicting evidence of the CNT toxicity, the PIs will undertake careful study of the interaction of well-characterized and purified CNTs with live cells. The CNT-cell interactions will be closely monitored spectroscopically and microscopically from the point of entry into the cell. The results will launch the development of novel nanomaterials for cellular therapies as well as deepen the understanding of cytoskeletal reorganization cellular functions. After analyzing and understanding the effects of CNTs on cell behavior, the investigators will modify the large surface areas of CNTs to design and develop non-destructive targeted cancer therapies.

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