Award Abstract # 0552060
REU Site in Cellular and Molecular Biology

NSF Org: DBI
Division of Biological Infrastructure
Recipient: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Initial Amendment Date: February 21, 2006
Latest Amendment Date: June 29, 2009
Award Number: 0552060
Award Instrument: Standard Grant
Program Manager: Sally O'Connor
DBI
 Division of Biological Infrastructure
BIO
 Directorate for Biological Sciences
Start Date: March 15, 2006
End Date: February 28, 2010 (Estimated)
Total Intended Award Amount: $0.00
Total Awarded Amount to Date: $344,014.00
Funds Obligated to Date: FY 2006 = $344,014.00
History of Investigator:
  • Jocelyn Spragg (Principal Investigator)
    jspragg@hms.harvard.edu
  • Sheila Thomas (Co-Principal Investigator)
Recipient Sponsored Research Office: Harvard University
1033 MASSACHUSETTS AVE STE 3
CAMBRIDGE
MA  US  02138-5366
(617)495-5501
Sponsor Congressional District: 05
Primary Place of Performance: Harvard University Medical School
25 SHATTUCK ST
BOSTON
MA  US  02115-6027
Primary Place of Performance
Congressional District:
07
Unique Entity Identifier (UEI): LN53LCFJFL45
Parent UEI:
NSF Program(s): RSCH EXPER FOR UNDERGRAD SITES
Primary Program Source: app-0106 
Program Reference Code(s): 9178, 9250, SMET
Program Element Code(s): 113900
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.074

ABSTRACT

This REU Site in Cellular and Molecular Biology is hosted by the Division of Medical Sciences at Harvard University. Ten students will be accepted in the 10-week summer program and provided research projects in molecular biology, cellular biology and/or microbiology. The objectives are to: (a) increase knowledge of basic biological research (b) develop students' interest in pursuing biological science research careers: (c) enhance related skills necessary for success; and (d) provide post-program advising and networking. Participants are recruited from a nation-wide pool, with particular emphasis on students who are interested in careers in research and members of under-represented minority groups. In addition to their research projects, students participate in weekly student-faculty research discussions at which they teach each other about their projects, and in a weekly career development series which covers such topics as choosing graduate programs, completing successful applications, and interviewing. Special skills sessions are also provided. Students participate in a peer advising/mentoring program with current graduate students and are provided additional opportunities to meet other research faculty and graduate students in both academic and social settings. Students receive a stipend, housing on the Medical School campus, travel to and from the program, and emergency illness and accident health insurance. Several mechanisms of formative and summative evaluation are employed. After participation in the REU summer, program alumni receive twice-yearly newsletters, contact information about each other, and open access to continued advising and counseling by the program director, their individual research advisors, and their peer mentors. More information is available at www.hms.harvard.edu/dms/diversity/shurpintro.html, or by contacting SHURP@hms.harvard.edu or 617 432-4980.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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(Showing: 1 - 10 of 17)
Appleton, BA; Brooks, J; Loregian, A; Filman, DJ; Coen, DM; Hogle, JM "Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit - Differences in structure and function relative to unliganded UL44" JOURNAL OF BIOLOGICAL CHEMISTRY , v.281 , 2006 , p.5224 View record at Web of Science 10.1074/jbc.M50690020
Aster, JC; Simms, WB; Zavala-Ruiz, Z; Patriub, V; North, CL; Blacklow, SC "The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent" BIOCHEMISTRY , v.38 , 1999 , p.4736 View record at Web of Science
Bringhurst, RM; Dominguez, AA; Schaffer, PA "Glutamine Deprivation Causes Enhanced Plating Efficiency of a Herpes Simplex Virus Type 1 ICP0-Null Mutant" JOURNAL OF VIROLOGY , v.82 , 2008 , p.11472 View record at Web of Science 10.1128/JVI.01086-0
Chen, JC; Minev, M; Beckwith, J "Analysis of ftsQ mutant alleles in Escherichia coli: Complementation, septal localization, and recruitment of downstream cell division proteins" JOURNAL OF BACTERIOLOGY , v.184 , 2002 , p.695 View record at Web of Science
D, HE; Hagen, SJ; Pothoulakis, C; Chen, M; Medina, ND; Warny, M; LaMont, JT "Clostridium difficile toxin A causes early damage to mitochondria in cultured cells" GASTROENTEROLOGY , v.119 , 2000 , p.139 View record at Web of Science
French, CA; Ramirez, CL; Kolmakova, J; Hickman, TT; Cameron, MJ; Thyne, ME; Kutok, JL; Toretsky, JA; Tadavarthy, AK; Kees, UR; Fletcher, JA; Aster, JC "BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells" ONCOGENE , v.27 , 2008 , p.2237 View record at Web of Science 10.1038/sj.onc.121085
Gehring, AM; Lees, WJ; Mindiola, DJ; Walsh, CT; Brown, ED "Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coli" BIOCHEMISTRY , v.35 , 1996 , p.579 View record at Web of Science
Ghaffari, S; Jagani, Z; Kitidis, C; Lodish, HF; Khosravi-Far, R "Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOX03a transcription factor" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , v.100 , 2003 , p.6523 View record at Web of Science 10.1073/pnas.073187110
Grossel, MJ; Wang, HM; Gadea, B; Yeung, W; Hinds, PW "A yeast two-hybrid system for discerning differential interactions using multiple baits" NATURE BIOTECHNOLOGY , v.17 , 1999 , p.1232 View record at Web of Science
Huber, D; Cha, MI; Debarbieux, L; Planson, AG; Cruz, N; Lopez, G; Tasayco, ML; Chaffotte, A; Beckwith, J "A selection for mutants that interfere with folding of Escherichia coli thioredoxin-1 in vivo" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , v.102 , 2005 , p.18872 View record at Web of Science 10.1073/pnas.050958310
Kadokura, H; Nichols, L; Beckwith, J "Mutational alterations of the key cis proline residue that cause accumulation of enzymatic reaction intermediates of DsbA, a member of the thioredoxin superfamily" JOURNAL OF BACTERIOLOGY , v.187 , 2005 , p.1519 View record at Web of Science 10.1128/JB.187.4.1519-1522.200
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