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Award Abstract # 0453189
REU Site: Functional Genomics Research Projects for Undergraduates

NSF Org: DBI
Division of Biological Infrastructure
Recipient: JACKSON LABORATORY
Initial Amendment Date: May 27, 2005
Latest Amendment Date: March 30, 2007
Award Number: 0453189
Award Instrument: Standard Grant
Program Manager: Sally O'Connor
DBI
 Division of Biological Infrastructure
BIO
 Directorate for Biological Sciences
Start Date: May 15, 2005
End Date: April 30, 2009 (Estimated)
Total Intended Award Amount: $0.00
Total Awarded Amount to Date: $283,800.00
Funds Obligated to Date: FY 2005 = $278,300.00
FY 2007 = $5,500.00
History of Investigator:
  • Barbara Knowles (Principal Investigator)
    barbara.knowles@jax.org
  • Jon Geiger (Co-Principal Investigator)
Recipient Sponsored Research Office: Jackson Laboratory
600 MAIN ST
BAR HARBOR
ME  US  04609-1523
(207)288-6772
Sponsor Congressional District: 02
Primary Place of Performance: Jackson Laboratory
600 MAIN ST
BAR HARBOR
ME  US  04609-1523
Primary Place of Performance
Congressional District:
02
Unique Entity Identifier (UEI): XR6LMXNKDJJ1
Parent UEI:
NSF Program(s): RSCH EXPER FOR UNDERGRAD SITES,
Ethics & Values of SET,
EPSCoR Co-Funding
Primary Program Source: app-0105 
app-0107 

app-0405 
Program Reference Code(s): 0000, 9150, 9152, 9178, 9184, 9250, 9251, BIOT, OTHR, SMET
Program Element Code(s): 113900, 791500, 915000
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.074

ABSTRACT

The Jackson Laboratory, a non-profit research institute in Bar Harbor, Maine, will conduct an internship program in functional genomics research for 10 undergraduate students within the framework of its existing Summer Student Program. The 11-week summer program - titled "REU Site: Functional Genomics Research Projects for Undergraduates" - will offer students hands-on training in interdisciplinary approaches linking the biological, physical, and computational sciences to investigations of genome function. Each student will perform an independent, hypothesis-driven research project as a member of a team under the mentorship of a Ph.D.-level, grant-funded principal investigator. Students will be selected through a competitive nationwide application process that will represent a diverse group with respect to gender, ethnicity, and economic background. Under-represented groups are encouraged to apply and will be actively recruited. Jackson's institutional commitment to the REU program includes providing students with access to intellectual and research resources such as courses and conferences, state-of-the-art instrumentation, and bioinformatics databases; dedicated program direction by the Education Office; and housing in an oceanfront dormitory overseen by professional staff. Jackson offers a stimulating environment in which undergraduates with a passion for hands-on experimental science can contribute to real research progress and make great strides in intellectual and personal growth. Point-of-contact is Dr. Jon R. Geiger, at (207) 288-6749 or summerstudents@jax.org. Additional information and an application are available on-line at http://www.jax.org/education/ssp.html.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Bubier, JA; Bennett, SM; Sproule, TJ; Lyons, BL; Olland, S; Young, DA; Roopenian, DC "Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus" AUTOIMMUNITY, PT B: NOVEL APPLICATIONS OF BASIC RESEARCH , v.1110 , 2007 , p.590 View record at Web of Science 10.1196/annals.1423.06
J.A. Bubier, S.M. Bennett (REU 2006) T.J. Sproule, B. Lyons, S. Olland, D.A. Young, D.C. Roopenian* "Treatment of BXSB-Yaa mice with IL-21R-Fc Fusion Protein Minimally Attenuates Systemic Lupus Erythematosus" Annals of NY Academy of Sciences, The Science of Autoimmunity: Cutting-Edge Advances in Basic Science , v.1110 , 2007 , p.590
Korstanje R*, Desai J, Lazar G, King B, Rollins J, Spurr M (REU 2003), Joseph J, Kadambi S, Li Y, Cherry A, Matteson P, Paigen B*, Millonig J "Quantitative trait loci affecting phenotypic variation in the vacuolated lens mouse mutant, a multigenic mouse model of neural tube defects" Physiological Genomics , v.35 , 2008 , p.296
Paigen K*, Szatkiewicz JP, Sawyer K (REU 2005), Leahy N, Parvanov ED, Ng SH, Graber JH, Broman KW, Petkov PM* "The recombinational anatomy of a mouse chromosome" PLoS Genet , v.11 , 2008 , p.e1000119
Yiguo Hu, Sarah Swerdlow (SSP 2004), Theodore M. Duffy, Roberto Weinmann, Francis Y. Lee, and *Shaoguang Li. "Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice." PNAS , v.103 , 2006 , p.16870

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