Award Abstract # 0416381
Fundamental Studies of Ion Formation from Charged and Neutral Drops with Applications to Gas Phase Ion Chemistry and Chemical Analysis

NSF Org: CHE
Division Of Chemistry
Recipient: CALIFORNIA INSTITUTE OF TECHNOLOGY
Initial Amendment Date: July 7, 2004
Latest Amendment Date: March 5, 2007
Award Number: 0416381
Award Instrument: Continuing Grant
Program Manager: Kelsey Cook
CHE  Division Of Chemistry
MPS  Directorate for Mathematical and Physical Sciences
Start Date: July 15, 2004
End Date: June 30, 2010 (Estimated)
Total Intended Award Amount: $0.00
Total Awarded Amount to Date: $680,000.00
Funds Obligated to Date: FY 2004 = $120,000.00
FY 2005 = $120,000.00
FY 2006 = $120,000.00
FY 2007 = $320,000.00
History of Investigator:
  • Jesse Beauchamp (Principal Investigator)
     jlbchamp@caltech.edu
Recipient Sponsored Research Office: California Institute of Technology
 1200 E CALIFORNIA BLVD
 PASADENA
 CA  US  91125-0001
(626)395-6219
Sponsor Congressional District: 28
Primary Place of Performance: California Institute of Technology
 1200 E CALIFORNIA BLVD
 PASADENA
 CA  US  91125-0001
Primary Place of Performance
Congressional District:		 28
Unique Entity Identifier (UEI): U2JMKHNS5TG4
Parent UEI:
NSF Program(s): ANALYTICAL SEPARATIONS & MEAS.
Primary Program Source: app-0104 
app-0105 
app-0106 
app-0107 
Program Reference Code(s): 0000, OTHR
Program Element Code(s): 197400
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.049

ABSTRACT

J. L. Beauchamp of the California Institute of Technology is supported by the Analytical and Surface Chemistry Program to study the mechanism of ion formation from charged and neutral drops with applications to gas phase ion chemistry and chemical analysis. Frontier research is planned in three areas, including (1) continued studies of the mechanism of desolvated ion formation from small charged droplets, expected to provide greater insights into the process of ion formation in electrospray ionization (ESI) (2) a new initiative to characterize a novel method developed in the PI laboratory using field induced droplet ionization (FIDI), to extract molecular ions and clusters from neutral droplets, based on neutral droplet instability in strong electric fields and (3) application of these methods to studies ranging from environmental analysis to nanoparticle chemistry.

These studies are expected to lead to new and efficient techniques for ion collection and analysis, with applications that include not only the sensitive detection of biological molecules, but also measurements of explosives, chemical and biological weapons agents, and chemicals of environmental interest.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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(Showing: 1 - 10 of 28)
Evan L. Neidholdt and J. L. Beauchamp "Switched Ferroelectric Plasma Ionizer (SwiFerr) for Ambient Mass Spectrometry" Anal. Chem. , v.79 , 2010 , p.3945 10.1021/ac1013833
Evan L. Neidholdt and J. L. Beauchamp "Switched Ferroelectric Plasma Ionizer (SwiFerr) for Ambient Mass Spectrometry" Anal. Chem. , v.83 , 2011 , p.38 10.1021/ac1013833
Evan L. Neidholdt and J.L. Beauchamp "Compact Ambient Pressure Pyroelectric Ion Source for Mass Spectrometry" Anal. Chem. , v.79 , 2007 , p.3945
Evan L. Neidholdt and J.L. Beauchamp "Compact Ambient Pressure Pyroelectric Ion Source for Mass Spectrometry" Anal. Chem. , v.79 , 2007 , p.3945 10.1021/ac070261s
Grimm, RL; Beauchamp, JL "Evaporation and Discharge Dynamics of Highly Charged Multicomponent Droplets Generated by Electrospray Ionization" JOURNAL OF PHYSICAL CHEMISTRY A , v.114 , 2010 , p.1411 View record at Web of Science 10.1021/jp907162
Heather A. Cox, Robert Hodyss, and J. L. Beauchamp "Cluster-Phase Reactions: Gas-Phase Phosphorylation of Peptides and Model Compounds with Triphosphate Anions" J. Am. Chem. Soc. , v.127 , 2005 , p.4084 10.1021/ja0452673
Heather A. Cox, Robert Hodyss, and J. L. Beauchamp "Cluster-Phase Reactions: Gas-Phase Phosphorylation of Peptides and Model Compounds with Triphosphate Anions" J. Am. Chem. Soc. , v.127 , 2005 , p.4084
Hugh I. Kim and J. L. Beauchamp "Cluster Phase Chemistry: Collisions of Vibrationally Excited Cationic Dicarboxylic Acid Clusters with Water Molecules Initiate Dissociation of Cluster Components" J. Phys. Chem. A , v.111 , 2007 , p.595 10.1021/jp0706580
Hugh I. Kim and J. L. Beauchamp "Cluster Phase Chemistry: Collisions of Vibrationally Excited Cationic Dicarboxylic Acid Clusters with Water Molecules Initiate Dissociation of Cluster Components" J.Phys. Chem. A , v.111 , 2007 , p.5954
Hugh I. Kim and J. L. Beauchamp "Cluster Phase Chemistry: Gas Phase Reactions of Cationic Sodium Salts of Dicarboxylic Acid Clusters with Water Molecules" J. Phys. Chem. A , v.111 , 2007 , p.595
Hugh I. Kim and J.L. Beauchamp "Identifying the Presence of Disulfide Linkages in Peptides by the Selective Elimination of Hydrogen Disulfide from Collisionally Activated Alkali and Alkaline Earth Metal Complexes" J. Amer. Chem. Soc. , v.130 , 2008
(Showing: 1 - 10 of 28)

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