NSF Org:	OISE Office of International Science and Engineering
Recipient:	UNIVERSITY OF ARKANSAS
Initial Amendment Date:	April 9, 2003
Latest Amendment Date:	April 9, 2003
Award Number:	0328398
Award Instrument:	Standard Grant
Program Manager:	Rose Gombay OISE  Office of International Science and Engineering O/D  Office Of The Director
Start Date:	March 1, 2003
End Date:	March 31, 2004 (Estimated)
Total Intended Award Amount:	$2,791.00
Total Awarded Amount to Date:	$2,791.00
Funds Obligated to Date:	FY 2000 = $2,791.00
History of Investigator:	Robert Gawley (Principal Investigator) bgawley@uark.edu
Recipient Sponsored Research Office:	University of Arkansas 1125 W MAPLE ST STE 316 FAYETTEVILLE AR  US  72701-3124 (479)575-3845
Sponsor Congressional District:	03
Primary Place of Performance:	University of Arkansas 1125 W MAPLE ST STE 316 FAYETTEVILLE AR  US  72701-3124
Primary Place of Performance Congressional District:	03
Unique Entity Identifier (UEI):	MECEHTM8DB17
Parent UEI:
NSF Program(s):	WESTERN EUROPE PROGRAM
Primary Program Source:	app-0100
Program Reference Code(s):	0000, 5946, OTHR
Program Element Code(s):	598000
Award Agency Code:	4900
Fund Agency Code:	4900
Assistance Listing Number(s):	47.079

ABSTRACT

0000096
Gawley

This two-year award for U.S.-U.K. collaboration in organic synthetic chemistry involves Robert E. Gawley and a postdoctoral researcher from the University of Miami and Iain Coldham of the University of Exeter. The objective of the collaboration is to develop new methods for the synthesis of complex heterocyclic compounds. The investigators will extend their work on the configurational stability of aminoorganolithiums. Both groups have studied reactivity patterns in these generally unstable compounds and propose to identify structural characteristics using complementary sets of related, yet different compounds.

The U.S. investigator brings to this collaboration a unique approach to the study and development of unstabilized alpha-lithio amines. This is complemented by the U.K. investigator's expertise on the structure and preparation of the compounds. His laboratory prepared a compound that demonstrated configurational stability even at room temperature. The project will advance understanding of new methods for synthesizing complex nitrogen heterocycles and of the science of organic synthesis. Heterocyclic compounds are important to pharmacology because the vast majority of pharmaceutical drugs contain the cyclical arrangement of molecules that are typically found in this system.

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