Award Abstract # 0315845
Brassinosteroid-Auxin Synergism to Dissect Hormone Response Pathways in Arabidopsis

NSF Org: MCB
Division of Molecular and Cellular Biosciences
Recipient: SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE
Initial Amendment Date: July 21, 2003
Latest Amendment Date: May 12, 2005
Award Number: 0315845
Award Instrument: Continuing Grant
Program Manager: Susan Porter Ridley
MCB
 Division of Molecular and Cellular Biosciences
BIO
 Directorate for Biological Sciences
Start Date: September 1, 2003
End Date: August 31, 2007 (Estimated)
Total Intended Award Amount: $575,000.00
Total Awarded Amount to Date: $575,000.00
Funds Obligated to Date: FY 2003 = $185,000.00
FY 2004 = $190,000.00

FY 2005 = $200,000.00
History of Investigator:
  • Joanne Chory (Principal Investigator)
    chory@salk.edu
Recipient Sponsored Research Office: The Salk Institute for Biological Studies
10010 N TORREY PINES RD
LA JOLLA
CA  US  92037-1002
(858)453-4100
Sponsor Congressional District: 50
Primary Place of Performance: The Salk Institute for Biological Studies
10010 N TORREY PINES RD
LA JOLLA
CA  US  92037-1002
Primary Place of Performance
Congressional District:
50
Unique Entity Identifier (UEI): NNJ6BMBTFGN5
Parent UEI:
NSF Program(s): Genetic Mechanisms,
INTEGRATIVE PLANT BIOLOGY
Primary Program Source: app-0103 
app-0104 

app-0105 
Program Reference Code(s): 1116, 9109, BIOT
Program Element Code(s): 111200, 114500
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.074

ABSTRACT

Plants are exquisitely sensitive to their light environment. Recent studies in the P.I.'s laboratory indicate that the plant hormones auxin and brassinosteroids (BRs) act in close proximity to modulate the seedling light response. The auxin and BR pathways have been studied individually in some detail, but significant gaps in each pathway exist. This project aims to identify components that may be shared between the auxin and BR signaling pathways. The primary aims are: (1) to characterize the BR-auxin interaction in Arabidopsis using existing physiological and genetic tools and (2) to uncover novel signal transduction components utilized by both hormones. This research will address the impact of the interaction between these hormones in regulating such diverse responses as changes in gene expression, cell expansion and division, and vascular differentiation. The long-term objective is to completely understand the signaling networks that regulate seedling development, and to relate this to general mechanisms of signal transduction in other organisms.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Geldner, N; Hyman, DL; Wang, XL; Schumacher, K; Chory, J "Endosomal signaling of plant steroid receptor kinase BRI1" GENES & DEVELOPMENT , v.21 , 2007 , p.1598 View record at Web of Science 10.1101/gad.156130
Hong, FX; Breitling, R; McEntee, CW; Wittner, BS; Nemhauser, JL; Chory, J "RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis" BIOINFORMATICS , v.22 , 2006 , p.2825 View record at Web of Science 10.1093/bioinformatics/btl47
Jennifer L. Nemhauser, Todd C. Mockler, Joanne Chory "Interdependency of Brassinosteroid and Auxin Signaling in Arabidopsis" PLoS Biology , v.2 , 2004 , p.1460
Jilian Fan, Sheng Quan, Travis Orth, Chie Awai, Joanne Chory, and Jianping Hu "The Arabidopsis PEX12 gene is required for peroxisome biogenesis and is" Plant Physiology , v.139 , 2005 , p.231
Nemhauser, JL; Hong, FX; Chory, J "Different plant hormones regulate similar processes through largely nonoverlapping transcriptional responses" CELL , v.126 , 2006 , p.467 View record at Web of Science 10.1016/j.cell.2006.05.05
Savaldi-Goldstein, S; Peto, C; Chory, J "The epidermis both drives and restricts plant shoot growth" NATURE , v.446 , 2007 , p.199 View record at Web of Science 10.1038/nature0561
Vert, G; Chory, J "Downstream nuclear events in brassinosteroid signalling" NATURE , v.441 , 2006 , p.96 View record at Web of Science 10.1038/nature0468
Yanhai Yin, Dionne Vafeados, Yi Tao, Shigeo Yoshida, Tadao Asami, Joanne Chory "A new class of transcription factors mediates brassinosteroid-regulated gene" Cell , v.120 , 2005 , p.249
Yin, YH; Vafeados, D; Tao, Y; Yoshida, S; Asami, T; Chory, J "A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis" CELL , v.120 , 2005 , p.249 View record at Web of Science 10.1016/j.cell.2004.11.04

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