| NSF Org: |
MCB Division of Molecular and Cellular Biosciences |
| Recipient: |
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| Initial Amendment Date: | February 6, 2002 |
| Latest Amendment Date: | May 8, 2006 |
| Award Number: | 0133484 |
| Award Instrument: | Continuing Grant |
| Program Manager: |
Kamal Shukla
MCB Division of Molecular and Cellular Biosciences BIO Directorate for Biological Sciences |
| Start Date: | March 1, 2002 |
| End Date: | February 29, 2008 (Estimated) |
| Total Intended Award Amount: | $645,000.00 |
| Total Awarded Amount to Date: | $657,000.00 |
| Funds Obligated to Date: |
FY 2003 = $120,000.00 FY 2004 = $120,000.00 FY 2005 = $131,000.00 FY 2006 = $131,000.00 |
| History of Investigator: |
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| Recipient Sponsored Research Office: |
4333 BROOKLYN AVE NE SEATTLE WA US 98195-1016 (206)543-4043 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
4333 BROOKLYN AVE NE SEATTLE WA US 98195-1016 |
| Primary Place of
Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): |
Molecular Biophysics, MOLECULAR BIOPHYSICS |
| Primary Program Source: |
app-0103 app-0104 app-0105 app-0106 |
| Program Reference Code(s): |
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| Program Element Code(s): |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.074 |
ABSTRACT
This CAREER award supports research in the characterization of "raft" domains in lipid monolayers and bilayers. Rafts are regions in cell membranes in which particular lipids and proteins are concentrated, and can play an important role in biological functions such as signaling. This research will test a central hypothesis that the phase behavior of raft domains in lipid vesicles can be predicted from the phase behavior of the same lipids in monolayers. Specific goals of this research include using fluorescence microscopy and 2-photon microscopy to identify raft domains in giant unilamellar vesicles using lipids known to form liquid ordered domains in monolayers. In addition, the research will test whether changing symmetry from a monolayer to a bilayer alters domain formation. This will be evaluated by searching for raft domains in monolayers deposited on a surface patterned with silanes or alkane-thiols. Long-term goals include assessing whether the presence of rafts alters the activity of membrane proteins.
Education efforts are focussed primarily on improving mathematical literacy of chemistry and biochemistry students. The importance of mathematics will be advertised to these students early in their college careers. A mathematics self-tutorial will be developed to clarify areas in which students need help. Resultant data will be used to guide curriculum changes. Study groups and e-mail threads will be instituted to help students learn from each other. Effort will also be directed to increasing departmental involvement of graduate students through a student-run colloquium series, and training students in the laboratory.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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