Award Abstract # 0122964
U.S.-Sweden Cooperative Research: Microfabricated Receptors by Combinatorial Imprinting in Aqueous Media

NSF Org: OISE
Office of International Science and Engineering
Recipient: PORTLAND STATE UNIVERSITY
Initial Amendment Date: March 20, 2002
Latest Amendment Date: April 26, 2007
Award Number: 0122964
Award Instrument: Standard Grant
Program Manager: Mark A. Suskin
OISE
 Office of International Science and Engineering
O/D
 Office Of The Director
Start Date: April 1, 2002
End Date: March 31, 2008 (Estimated)
Total Intended Award Amount: $0.00
Total Awarded Amount to Date: $28,440.00
Funds Obligated to Date: FY 2002 = $28,440.00
History of Investigator:
  • Mingdi Yan (Principal Investigator)
Recipient Sponsored Research Office: Portland State University
1600 SW 4TH AVE
PORTLAND
OR  US  97201-5508
(503)725-9900
Sponsor Congressional District: 01
Primary Place of Performance: Portland State University
1600 SW 4TH AVE
PORTLAND
OR  US  97201-5508
Primary Place of Performance
Congressional District:
01
Unique Entity Identifier (UEI): H4CAHK2RD945
Parent UEI: WWUJS84WJ647
NSF Program(s): WESTERN EUROPE PROGRAM
Primary Program Source: app-0102 
Program Reference Code(s): 0000, 5937, OTHR
Program Element Code(s): 598000
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.079

ABSTRACT

0122964
Yan
This award supports Mingdi Yan and students from Portland State University in a collaboration with Olof Ramstrom of the Department of Organic Chemistry at the Royal Institute of Technology in Stockholm, Sweden. The project will focus on the difficult tasks of synthesis and use of in aqueous solutions of tailor-made polymeric receptors that are capable of selectively recognizing small differences in ligand structure. New chemistry and fabrication techniques will be applied to molecular imprinting in order to meet the challenge, which is of utmost importance in biological applications. The imprinting chemistry employs reversible, but stable bonds that survive the water environment. The technique of micromoulding in capillary will be used for the synthesis of molecularly imprinted polymers. The same technique will make it possible to accomplish the synthesis of libraries of such polymers that can be screened for optimal imprinting chemistry as well as for biological assays. The long-term goals of the project are to integrate the synthesis and analysis of combinatorial molecularly imprinted polymers on a single chip and to construct multi-analyte sensors based on the microfabricated arrays.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Harnish, B.; Robinson, J. T.; Pei, Z.; Ramström, O.; Yan, M. "UV-Cross-Linked Poly(4-vinylpyridine) Thin Films as Reversibly Responsive Surfaces" Chem. Mater. , v.17 , 2005 , p.4092
Pei, Y.; Yu, H.; Pei, Z.; Theurer, M.; Yan, M.; Ramstrom, O. "Photoligated carbohydrate surfaces for lectin analysis" Anal. Chem. , v.79 , 2007 , p.6897
Pei, Z.; Yu, H.; Theurer, M.; Walden, A.; Nilsson, P.; Yan, M.; Ramstrom, O. "Photogenerated carbohydrate microarrays" ChemBioChem , v.8 , 2007 , p.166

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