Award Abstract # 9732843
Development and Application of Oligonucleotide Synthesis Methods

NSF Org: CHE
Division Of Chemistry
Recipient: COLORADO STATE UNIVERSITY
Initial Amendment Date: April 10, 1998
Latest Amendment Date: April 25, 2002
Award Number: 9732843
Award Instrument: Continuing Grant
Program Manager: Kenneth M. Doxsee
CHE
 Division Of Chemistry
MPS
 Directorate for Mathematical and Physical Sciences
Start Date: June 1, 1998
End Date: February 28, 2003 (Estimated)
Total Intended Award Amount: $351,000.00
Total Awarded Amount to Date: $351,000.00
Funds Obligated to Date: FY 1998 = $135,000.00
FY 1999 = $108,000.00

FY 2001 = $94,291.00
History of Investigator:
  • Marc Greenberg (Principal Investigator)
    mgreenberg@jhu.edu
Recipient Sponsored Research Office: Colorado State University
601 S HOWES ST
FORT COLLINS
CO  US  80521-2807
(970)491-6355
Sponsor Congressional District: 02
Primary Place of Performance: Colorado State University
601 S HOWES ST
FORT COLLINS
CO  US  80521-2807
Primary Place of Performance
Congressional District:
02
Unique Entity Identifier (UEI): LT9CXX8L19G1
Parent UEI:
NSF Program(s): SYNTHESIS
Primary Program Source: 01000102DB NSF RESEARCH & RELATED ACTIVIT
app-0198 

app-0199 
Program Reference Code(s): 9183, BIOT
Program Element Code(s): 194800
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.049

ABSTRACT

The proposed research involves the synthesis of novel `orthogonal` solid phase supports. These will be used for the preparation of protected oligonucleotides, and oligonucleotide conjugates with functional groups or peptides attached at defined positions. Related oligoribonucleotides will also be prepared. The research will extend the types of reactions that can be used to cleave the oligonucleotides from the solid support to include reductive and enzymatic reactions, and extend the scope of chemistry available for conjugating protected oligonucleotides. With this renewal award, the Organic and Macromolecular Chemistry Program supports the research of Dr. Marc M. Greenberg of the Department of Chemistry at Colorado State University. The research focuses on developing solid phase supports from which protected fragments of DNA and RNA can be cleaved under mild conditions, and on expanding the repertoire of reactions available for extending the number of nucleotides linked to form the oligomers. The work will provide useful approaches to others attempting to synthesize oligonucleotides, and will have practical biomedical applications. Graduate students and post-doctoral fellows will receive training in the synthesis of small molecules and biopolymers, and get the kind of training needed in the growing biotechnology area.

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