
NSF Org: |
CHE Division Of Chemistry |
Recipient: |
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Initial Amendment Date: | April 10, 1998 |
Latest Amendment Date: | April 25, 2002 |
Award Number: | 9732843 |
Award Instrument: | Continuing Grant |
Program Manager: |
Kenneth M. Doxsee
CHE Division Of Chemistry MPS Directorate for Mathematical and Physical Sciences |
Start Date: | June 1, 1998 |
End Date: | February 28, 2003 (Estimated) |
Total Intended Award Amount: | $351,000.00 |
Total Awarded Amount to Date: | $351,000.00 |
Funds Obligated to Date: |
FY 1999 = $108,000.00 FY 2001 = $94,291.00 |
History of Investigator: |
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Recipient Sponsored Research Office: |
601 S HOWES ST FORT COLLINS CO US 80521-2807 (970)491-6355 |
Sponsor Congressional District: |
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Primary Place of Performance: |
601 S HOWES ST FORT COLLINS CO US 80521-2807 |
Primary Place of
Performance Congressional District: |
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Unique Entity Identifier (UEI): |
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Parent UEI: |
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NSF Program(s): | SYNTHESIS |
Primary Program Source: |
app-0198 app-0199 |
Program Reference Code(s): |
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Program Element Code(s): |
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Award Agency Code: | 4900 |
Fund Agency Code: | 4900 |
Assistance Listing Number(s): | 47.049 |
ABSTRACT
The proposed research involves the synthesis of novel `orthogonal` solid phase supports. These will be used for the preparation of protected oligonucleotides, and oligonucleotide conjugates with functional groups or peptides attached at defined positions. Related oligoribonucleotides will also be prepared. The research will extend the types of reactions that can be used to cleave the oligonucleotides from the solid support to include reductive and enzymatic reactions, and extend the scope of chemistry available for conjugating protected oligonucleotides. With this renewal award, the Organic and Macromolecular Chemistry Program supports the research of Dr. Marc M. Greenberg of the Department of Chemistry at Colorado State University. The research focuses on developing solid phase supports from which protected fragments of DNA and RNA can be cleaved under mild conditions, and on expanding the repertoire of reactions available for extending the number of nucleotides linked to form the oligomers. The work will provide useful approaches to others attempting to synthesize oligonucleotides, and will have practical biomedical applications. Graduate students and post-doctoral fellows will receive training in the synthesis of small molecules and biopolymers, and get the kind of training needed in the growing biotechnology area.
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