NSF Org:	IOS Division Of Integrative Organismal Systems
Recipient:	UNIVERSITY OF PUERTO RICO
Initial Amendment Date:	July 21, 1988
Latest Amendment Date:	June 15, 1992
Award Number:	8801538
Award Instrument:	Standard Grant
Program Manager:	Kathie L. Olsen IOS  Division Of Integrative Organismal Systems BIO  Directorate for Biological Sciences
Start Date:	August 1, 1988
End Date:	January 31, 1994 (Estimated)
Total Intended Award Amount:	$247,309.00
Total Awarded Amount to Date:	$247,309.00
Funds Obligated to Date:	FY 1988 = $41,943.00 FY 1989 = $51,417.00 FY 1990 = $44,953.00 FY 1991 = $51,797.00 FY 1992 = $57,199.00
History of Investigator:	Jose Garcia-Arraras (Principal Investigator) jegarcia@hpcf.upr.edu
Recipient Sponsored Research Office:	University of Puerto Rico-Rio Piedras 39 PONCE DE LEON AVE SAN JUAN PR  US  00931 (787)763-4949
Sponsor Congressional District:	00
Primary Place of Performance:	DATA NOT AVAILABLE
Primary Place of Performance Congressional District:
Unique Entity Identifier (UEI):	Q3LLLDFHPNL3
Parent UEI:
NSF Program(s):	NEUROENDOCRINOLOGY, CROSS-DIRECTORATE PROGRAMS, SPECIAL PROGRAMS-RESERVE
Primary Program Source:
Program Reference Code(s):	9251, 9137, 9135
Program Element Code(s):	119300, 912000, 914500
Award Agency Code:	4900
Fund Agency Code:	4900
Assistance Listing Number(s):	47.074

ABSTRACT

The peripheral nervous system is formed, almost in its entirety by neural crest cells that migrate and associate in specific areas of the developing embryo. During the process of gangliogenesis these cells acquire particular traits and eventually differentiate into the various phenotypes found in the adult. The aims of this research are: (1) to document the development of peptidergic phenotypes in the sympathoadrenal branch of the peripheral nervous system, from neural crest cells to the terminally differentiated state found in the chicken and quail adult and (2) to examine the influence of extrinsic factors on peptidergic expression by culturing neural crest cells and dissociated embryonic ganglion cells in the presence of conditioned media, cell free extracts, or hormones, and other factors likely to be encountered by developing crest cells. Results from this project will provide a precise map of the peptidergic cell populations in the developing peripheral nervous system and the time course of their appearance. They will also define the contribution of environmental mechanisms to the induction and maintenance of peptidergic phenotypes. In addition, these results will provide basic embryological information that could aid considerably our understanding of the mechanisms underlying the development and plasticity of peripheral nervous system.

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