Award Abstract # 2152254
Design and Manufacturing of Medical Devices and Implants: Cultivating a Human- Centered Mindset

NSF Org: DGE
Division Of Graduate Education
Recipient: ARIZONA STATE UNIVERSITY
Initial Amendment Date: June 24, 2022
Latest Amendment Date: July 13, 2024
Award Number: 2152254
Award Instrument: Standard Grant
Program Manager: Liz Webber
ewebber@nsf.gov
 (703)292-4316
DGE
 Division Of Graduate Education
EDU
 Directorate for STEM Education
Start Date: July 1, 2022
End Date: June 30, 2027 (Estimated)
Total Intended Award Amount: $3,000,000.00
Total Awarded Amount to Date: $3,320,306.00
Funds Obligated to Date: FY 2022 = $3,000,000.00
FY 2023 = $194,046.00

FY 2024 = $126,260.00
History of Investigator:
  • Leila Ladani (Principal Investigator)
    leila.j.ladani@gmail.com
Recipient Sponsored Research Office: Arizona State University
660 S MILL AVENUE STE 204
TEMPE
AZ  US  85281-3670
(480)965-5479
Sponsor Congressional District: 04
Primary Place of Performance: Arizona State University
AZ  US  85287-6011
Primary Place of Performance
Congressional District:
04
Unique Entity Identifier (UEI): NTLHJXM55KZ6
Parent UEI:
NSF Program(s): NSF Research Traineeship (NRT)
Primary Program Source: 04002425DB NSF STEM Education
04002324DB NSF STEM Education

04002223DB NSF Education & Human Resource
Program Reference Code(s): 9179, SMET, 9102
Program Element Code(s): 199700
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.076

ABSTRACT

Technological advances are revolutionizing the medical device industry; and healthcare makes up one of the largest and fastest-growing job sectors in the United States. However, due to the traditional separation between career trajectories in science, technology, engineering, and mathematics (STEM) and those in the healthcare sector, STEM graduate students often do not have training in a clinical setting. Consequently, many are not aware of the ethical principles, laws, and policies associated with the development and use of technologies in those settings. As a result, advancements and innovations made in the design and manufacturing of biomedical devices in academic institutions often do not appropriately address the application side of the technology. This gap in STEM education can be addressed by developing a convergent research program that weaves different disciplines together. Knowledge of the applied side of medical technology research is necessary for effective and sustainable innovation. This NSF Research Traineeship (NRT) project brings together the awardee institution with the Mayo Clinic in Arizona, to address this gap by creating and fostering a use-inspired, human-centered outlook in STEM graduate students through a set of structured and convergent research and training activities. The project anticipates training 34 Ph.D. students, including 17 funded trainees from engineering, design, manufacturing, and science disciplines.

Trainees will focus on research problems associated with imaging devices and technologies, additively manufactured implants and devices, personable diagnostic devices, tissue repair and regeneration devices, and applications of cybersecurity, data science, and artificial intelligence to medical devices. Trainees will follow a training schedule consisting of NRT core curriculum courses, applied and experiential learning components, including a Mayo Clinic residency, MedTech accelerator participation, a Graduate-Undergraduate Mentorship (GUM) Program, and experiential and professional activities. NRT trainees will learn aspects that are not traditionally part of STEM education, such as limitations and opportunities for technology-human interactions in medical and clinical settings. They will also gain an understanding of ethical principles and develop an entrepreneurial mindset and aptitude. This training experience will enhance students? education by providing breath in the three research thrust areas: (1) Human-technology interface in medical devices, (2) Ethics in research and innovation, (3) Law and policies in research and technology. Cross-disciplinary teams of faculty are selected as the advising team for each NRT trainee; and tudents will integrate at least one of these research thrusts into their specific research topic through their dissertation.

The NSF Research Traineeship (NRT) Program is designed to encourage the development and implementation of bold, new potentially transformative models for STEM graduate education training. The program is dedicated to effective training of STEM graduate students in high priority interdisciplinary or convergent research areas through comprehensive traineeship models that are innovative, evidence-based, and aligned with changing workforce and research needs.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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(Showing: 1 - 10 of 28)
Sadeghilaridjani, Maryam and Ladani, Leila "Location-dependent deformation behavior of additively manufactured copper and copper-carbon nanotube composite" Journal of Alloys and Compounds , v.909 , 2022 https://doi.org/10.1016/j.jallcom.2022.164800 Citation Details
Ahsan, Faiyaz and Razmi, Jafar and Ladani, Leila "Global local modeling of melt pool dynamics and bead formation in laser bed powder fusion additive manufacturing using a multi-physics thermo-fluid simulation" Progress in Additive Manufacturing , v.7 , 2022 https://doi.org/10.1007/s40964-022-00302-w Citation Details
Dahlstrom, Kristina R and Anderson, Karen S and Sturgis, Erich M "Abstract PO-037: Biomarkers for early diagnosis of human papillomavirus-related oropharyngeal cancer" Clinical Cancer Research , v.29 , 2023 https://doi.org/10.1158/1557-3265.aacrahns23-po-037 Citation Details
Ewaisha, Radwa and Anderson, Karen S. "Immunogenicity of CRISPR therapeuticsCritical considerations for clinical translation" Frontiers in Bioengineering and Biotechnology , v.11 , 2023 https://doi.org/10.3389/fbioe.2023.1138596 Citation Details
Fei-Zhang, David J and Cuenca, Camaren M and Haskins, Angela D and Stein, Andrew P and Lott, David G and Patel, Urjeet A and Smith, Stephanie S and Dimachkieh, Amy L and Osazuwa-Peters, Nosayaba and DSouza, Jill N and Sheyn, Anthony M and Rastatter, Jeff "Assessments of social vulnerability on laryngeal cancer treatment & prognosis in the US" British Journal of Cancer , 2025 https://doi.org/10.1038/s41416-025-03056-8 Citation Details
Filarski, Carolyn F and Donald, Carrlene B and Mendez, Anthony P and Lott, David G "Airway obstruction secondary to vocal cord polyp" JAAPA , v.37 , 2024 https://doi.org/10.1097/01.JAA.0000000000000124 Citation Details
Gadalla, Dina and Kennedy, Maeve and Lott, David "Protocol for the Implantation of Scaffolds in a Humanized Mouse Cutaneous Excisional Wound Healing Model" BIO-PROTOCOL , v.14 , 2024 https://doi.org/10.21769/BioProtoc.4974 Citation Details
Gadalla, Dina and Kennedy, Maeve M and Lott, David G "Advancements and Challenges in Tracheal Epithelium Regeneration: Insights into Tissue Engineering Approaches" Cells Tissues Organs , 2025 https://doi.org/10.1159/000545132 Citation Details
Gately, Ursula E and Zhang, Nan and Karle, William E and Lott, David G "Adjuvant Intralesional Bevacizumab in Pediatric and Adult Populations With Recurrent Respiratory Papillomatosis: A Systematic Review" Annals of Otology, Rhinology & Laryngology , v.133 , 2024 https://doi.org/10.1177/00034894241264388 Citation Details
Ghosh, Deepanjan and Salinas, Christopher M. and Pallod, Shubham and Roberts, Jordan and Makin, Inder Raj and Yaron, Jordan R. and Witte, Russell S. and Rege, Kaushal "Temporal evaluation of efficacy and quality of tissue repair upon laseractivated sealing" Bioengineering & Translational Medicine , v.8 , 2023 https://doi.org/10.1002/btm2.10412 Citation Details
Gregor, Jessica W and Lott, David G and Kahn, Allon "Comprehensive Multidisciplinary Evaluation of Dysphagia" Clinical Gastroenterology and Hepatology , v.23 , 2025 https://doi.org/10.1016/j.cgh.2024.12.002 Citation Details
(Showing: 1 - 10 of 28)

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