Award Abstract # 2122108
NMHU-BioPACIFIC MIP collaboration in design, synthesis and applications of metal-organic hybrid biomaterials

NSF Org: DMR
Division Of Materials Research
Recipient: NEW MEXICO HIGHLANDS UNIVERSITY
Initial Amendment Date: July 12, 2021
Latest Amendment Date: August 16, 2024
Award Number: 2122108
Award Instrument: Continuing Grant
Program Manager: Tomasz Durakiewicz
tdurakie@nsf.gov
 (703)292-4892
DMR
 Division Of Materials Research
MPS
 Directorate for Mathematical and Physical Sciences
Start Date: July 1, 2021
End Date: June 30, 2027 (Estimated)
Total Intended Award Amount: $3,799,000.00
Total Awarded Amount to Date: $2,900,846.00
Funds Obligated to Date: FY 2021 = $831,740.00
FY 2022 = $593,452.00

FY 2023 = $638,452.00

FY 2024 = $837,202.00
History of Investigator:
  • Gil Gallegos (Principal Investigator)
    grgallegos@nmhu.edu
  • Tatiana Timofeeva (Co-Principal Investigator)
  • Jennifer Lindline (Co-Principal Investigator)
  • Michael Petronis (Co-Principal Investigator)
  • Javier Read de Alaniz (Co-Principal Investigator)
  • Kelly Trujillo (Former Co-Principal Investigator)
Recipient Sponsored Research Office: New Mexico Highlands University
800 W NATIONAL AVE
LAS VEGAS
NM  US  87701-4002
(505)454-3571
Sponsor Congressional District: 03
Primary Place of Performance: New Mexico Highlands University
810 National Avenue
Las Vegas
NM  US  87701-9000
Primary Place of Performance
Congressional District:
03
Unique Entity Identifier (UEI): N9GLBGC6U6M1
Parent UEI:
NSF Program(s): OFFICE OF MULTIDISCIPLINARY AC,
PREM,
EPSCoR Co-Funding
Primary Program Source: 01002223DB NSF RESEARCH & RELATED ACTIVIT
01002526DB NSF RESEARCH & RELATED ACTIVIT

01002627DB NSF RESEARCH & RELATED ACTIVIT

01002122DB NSF RESEARCH & RELATED ACTIVIT

01002324DB NSF RESEARCH & RELATED ACTIVIT

01002425DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s): 102Z, 9178, 094Z, 9150, 7573, 095Z, 1711
Program Element Code(s): 125300, 791300, 915000
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.049, 47.083

ABSTRACT

New Mexico Highlands University (NMHU) is a small liberal arts university in Northern New Mexico. It has a student body composed of 53.6% Hispanic Americans and 66.4% women. Many of these students are from low-income first-generation college families. This proposal presents a partnership with the NSF-supported BioPolymers, Automated Cellular Infrastructure, Flow, and integrated Chemistry Materials Innovation Platform (BioPACIFIC MIP) at University of California, Santa Barbara (UCSB) and University of California, Los Angeles (UCLA). Faculty in chemistry, biochemistry, computer science, geology, and chemical engineering will provide materials science education and hands-on training for research to students from underrepresented groups. The Partnership in Research and Education for Materials (PREM) pathway, developed with collaborative efforts from NMHU, UCSB and UCLA, will focus on recruitment, retention, and degree attainment for the students. Professional development for students will take place throughout the year both at NMHU as well as in the BioPACIFIC MIP Summer School. At BioPACIFIC MIP PREM students will have networking opportunities at multiple levels including with community leaders, faculty, staff, graduate students, and postdocs as well as peer-to-peer. The NMHU?BioPACIFIC MIP PREM will systematically engage high school students, undergraduates, graduate students, and postgraduates at all partner institutions. In New Mexico, at the high school level, the PREM will utilize dual credits for high school students and the Achieving in Research, Mathematics and Science (ARMAS) Center to encourage and engage students from underrepresented groups in science education programs. At NMHU, in collaboration with BioPACIFIC MIP, two new materials science courses, devoted to an in-depth understanding of materials structure and properties, will be designed. The PREM program will involve at least 12 BS or MS NMHU PREM students per year. The research outcome will be disseminated through publications, with a goal of at least 10 articles per year in peer reviewed journals with student co-authors in at least 80% of those publications. This project is partially supported with co-funding from the Established Program to Stimulate Competitive Research (EPSCoR).

The proposed research will include machine learning, materials synthesis, high-throughput automated chemistry/biosynthesis, and applications of organic-inorganic materials. By bridging machine learning and synthetic chemistry (closing the design loop), a wider combination of bioinspired building blocks will be designed to go beyond the current biomaterial landscape. This will enable the use of two or more organic/inorganic components in one material which is necessary to tune structural, optical, electronic, and magnetic properties of a multi-component material. Resultant small molecules, organic polymers, and organic-inorganic porous materials will also allow for designing of biosensors, drug delivery systems, materials for chiral chromatography and templates for polymerization. The partnership between NMHU and BioPACIFIC MIP will allow NMHU re-searchers and students to establish a new area of materials research at NMHU. Development of new expertise will be supported by access of NMHU faculty, postdoctoral fellows and students to scientific expertise and advanced instrumentation at BioPACIFIC MIP to rapidly accelerate discovery of materials. The collaborative teams will hold research-focused group meetings via real-time video teleconferencing. Students will visit BioPACIFIC MIP laboratories. Two to three NMHU undergraduates will travel to BioPACIFIC MIP each year for summer research. One or more NMHU MS students will go to BioPACIFIC MIP to take courses and do research for one semester, and a PREM Annual Retreat will be held each year, alternating between NMHU and UCSB.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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(Showing: 1 - 10 of 26)
Shambilova, Gulbarshin K and Bukanova, Aigul S and Kalauova, Altynay S and Kalimanova, Danagul Zh and Abilkhairov, Amangeldi I and Makarov, Igor S and Vinogradov, Markel I and Makarov, Georgy I and Yakimov, Sergey A and Koksharov, Alexander V and Novikov, "An Experimental Study on the Solubility of Betulin in the Complex Solvent Ethanol-DMSO" Processes , v.12 , 2024 https://doi.org/10.3390/pr12061179 Citation Details
Averkiev, Boris B. and Castañeda, Raúl and Fonari, Marina S. and Jucov, Evgheni V. and Timofeeva, Tatiana V. "Additive controlled packing polymorphism in a series of halogen-substituted dithieno[3,2- <i>a</i> :2,3- <i>c</i> ]phenazine derivatives" CrystEngComm , v.25 , 2023 https://doi.org/10.1039/D3CE00387F Citation Details
Bailey, Sophia J. and Hopkins, Erik and Rael, Kiara D. and Hashmi, Arsalan and Urueña, Juan Manuel and Wilson, Maxwell Z. and Read de Alaniz, Javier "Design, Synthesis, and Application of a Watersoluble Photocage for Aqueous Cyclopentadienebased DielsAlder Photoclick Chemistry in Hydrogels" Angewandte Chemie International Edition , v.62 , 2023 https://doi.org/10.1002/anie.202301157 Citation Details
Castañeda, Raúl and Lindeman, Sergei V. and Krivoshein, Arcadius V. and Metta-Magaña, Alejandro J. and Chen, Yongli and Timofeeva, Tatiana V. "Remarkable Similarity of Molecular Packing in Crystals of Racemic and Enantiopure 2-Phenylpropionamide: Z = 4 Structures, Molecular Disorder, and the Formation of a Partial Solid Solution" Crystal Growth & Design , v.22 , 2022 https://doi.org/10.1021/acs.cgd.2c00509 Citation Details
Deniz, Melike Nur and Ashfaq, Muhammad and Ozturk, Seyhan and Novikov, Egor and Tahir, Muhammad Nawaz and Aghayeva, Saltanat Arshad and Islam, Mohammad Shahidul and Dege, Necmi and Almutairi, Tahani Mazyad and Mali, Suraj N "Cobalt(II) Complex Constructed from Pyrazinecarboxamide and Aromatic Carboxylic Acid: Synthesis, Single Crystal XRD Along with Computational Study" Journal of Computational Biophysics and Chemistry , v.23 , 2024 https://doi.org/10.1142/S2737416524500455 Citation Details
Fonari, Marina S. and Rigin, Sergei and Lesse, Daniel and Timofeeva, Tatiana V. "Co-crystals of polynuclear aromatic hydrocarbons and 9H-carbazole with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone acceptor: Varieties in crystal packing, Hirshfeld surface analysis and quantum-chemical studies" Journal of Molecular Structure , v.1278 , 2023 https://doi.org/10.1016/j.molstruc.2023.134900 Citation Details
Gogia, Alisha and Novikov, Egor M. and Guzei, Ilia A. and Fonari, Marina S. and Timofeeva, Tatiana V. "Crystal structure and characterization of a new one-dimensional copper(II) coordination polymer containing a 4-aminobenzoic acid ligand" Acta Crystallographica Section E Crystallographic Communications , v.80 , 2024 https://doi.org/10.1107/S2056989024001336 Citation Details
Guillen_Campos, Jesus and Park, Minwook and Wu, Yuhang and Sandlass, Sara and Novikov, Egor M and Bailey, Sophia J and Gordon, Michael and Timofeeva, Tatiana V and Read_de_Alaniz, Javier "Synthesis of photoresponsive liquid crystal elastomers: a general chemical approach" Journal of Materials Chemistry A , 2025 https://doi.org/10.1039/D5TA01043H Citation Details
Kalauova, Altynay S and Palchikova, Ekaterina E and Makarov, Igor S and Shandryuk, Georgiy A and Abilkhairov, Amangeldi I and Kalimanova, Danagul Zh and Naukenov, Meirbek Zh and Shambilova, Gulbarshin K and Novikov, Egor M and Song, Junlong and Smyslov, A "Specificity of Thermal Destruction of Nonwoven Mixture Systems Based on Bast and Viscose Fibers" Polymers , v.17 , 2025 https://doi.org/10.3390/polym17091223 Citation Details
Kornilova, Tatiana and Glebov, Viktor and Castañeda, Raúl and Timofeeva, Tatiana V. "A new pseudopolymorph of berberine chloride: crystal structure and Hirshfeld surface analysis" Acta Crystallographica Section E Crystallographic Communications , v.78 , 2022 https://doi.org/10.1107/S2056989022003309 Citation Details
Marquez, Jason and Novikov, Egor and Rigin, Sergei and Fonari, Marina S. and Castañeda, Raúl and Kornilova, Tatiana and Timofeeva, Tatiana V. "Exploiting Supramolecular Synthons in Cocrystals of Two Racetams with 4-Hydroxybenzoic Acid and 4-Hydroxybenzamide Coformers" Chemistry , v.5 , 2023 https://doi.org/10.3390/chemistry5020074 Citation Details
(Showing: 1 - 10 of 26)

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