Award Abstract # 2106924
Self-Assembly of Multicomponent Nanostructures

NSF Org: CHE
Division Of Chemistry
Recipient: OHIO STATE UNIVERSITY, THE
Initial Amendment Date: May 27, 2021
Latest Amendment Date: May 27, 2021
Award Number: 2106924
Award Instrument: Standard Grant
Program Manager: Suk-Wah Tam-Chang
stamchan@nsf.gov
 (703)292-8684
CHE
 Division Of Chemistry
MPS
 Directorate for Mathematical and Physical Sciences
Start Date: July 1, 2021
End Date: June 30, 2025 (Estimated)
Total Intended Award Amount: $525,000.00
Total Awarded Amount to Date: $525,000.00
Funds Obligated to Date: FY 2021 = $525,000.00
History of Investigator:
  • Jon Parquette (Principal Investigator)
    parquett@chemistry.ohio-state.edu
Recipient Sponsored Research Office: Ohio State University
1960 KENNY RD
COLUMBUS
OH  US  43210-1016
(614)688-8735
Sponsor Congressional District: 03
Primary Place of Performance: Ohio State University
Office of Sponsored Programs
Columbus
OH  US  43210-1016
Primary Place of Performance
Congressional District:
03
Unique Entity Identifier (UEI): DLWBSLWAJWR1
Parent UEI: MN4MDDMN8529
NSF Program(s): Macromolec/Supramolec/Nano
Primary Program Source: 01002122DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s): 106Z, 7237
Program Element Code(s): 688500
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.049

ABSTRACT

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the NSF Division of Chemistry, Professor Jon Parquette of Ohio State University will develop new strategies to construct multicomponent nanomaterials via the self-assembly of simple building blocks. The capability to build abiological nanomaterials comprised of discrete, self-sorted domains is expected to enable the emergence of novel properties that will drive the development of novel biomaterials, drug delivery modalities, catalysts, and optoelectronic materials. This work will create a platform to also address other problems in human health and society, such as renewable energy, greenhouse gas conversion, and medicine. This project will be used to enhance public awareness of nanoscience in society and will expose a diversity of students to scientific research. The PI will achieve these goals by supervising undergraduate and high school students in research, by mentoring undergraduate career clubs, and by participating in science exhibitions at Columbus Center of Science and Industry (COSI) as a member the Center of Applied Plant Science (CAPS) at Ohio State University.

This research aims to gain a better fundamental understanding of the factors that govern "self/non-self" interaction at the nanostructure level and to establish new design principles to construct multicomponent hierarchical architectures by the coassembly of spatially sorted domains of components. This is important because the nanoscale organization of the components of an assembled structure critically impacts the functional attributes of a nanomaterial. The first aim of this work will construct block sequences of two types of supramolecular rings within a self-assembled nanotube via a heterogeneous nucleation-elongation mechanism. The second aim facilitates the interactions between the separate domains by incorporating an intervening polydopamine layer to stabilize one component and mediate further interactions with additional assembled structures. Transient nanostructures that only persist in the presence of fuel play critical roles in living cells, such as controlling the mechanical properties of the cytoskeleton. Thus, the third aim of this work will focus on the design of transient multicomponent hydrogels that exhibit time-dependent physical/optical characteristics, whose temporal evolution can be directly visualized using confocal light microscopy.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

Note:  When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

Lee, Aejin and Mason, McKensie L. and Lin, Tao and Kumar, Shashi Bhushan and Kowdley, Devan and Leung, Jacob H. and Muhanna, Danah and Sun, Yuan and Ortega-Anaya, Joana and Yu, Lianbo and Fitzgerald, Julie and DeVries, A. Courtney and Nelson, Randy J. and "Amino Acid Nanofibers Improve Glycemia and Confer Cognitive Therapeutic Efficacy to Bound Insulin" Pharmaceutics , v.14 , 2022 https://doi.org/10.3390/pharmaceutics14010081 Citation Details
Linville, Jenae J and Mason, McKensie L and Lopez-Torres, Edgar U and Parquette, Jon R "Electrostatic assembly of a multicomponent peptide/amphiphile nanotube" Nanoscale , v.16 , 2024 https://doi.org/10.1039/d3nr03482h Citation Details
Liu, Mengmeng and Creemer, Cassidy N. and Reardon, Thomas J. and Parquette, Jon R. "Light-driven dissipative self-assembly of a peptide hydrogel" Chemical Communications , v.57 , 2021 https://doi.org/10.1039/D1CC04971B Citation Details
Mason, McKensie L. and Lin, Tao and Linville, Jenae J. and Parquette, Jon R. "Co-assembly of a multicomponent network of nanofiber-wrapped nanotubes" Nanoscale , v.14 , 2022 https://doi.org/10.1039/D1NR08508E Citation Details
Meng, Ziyuan and Taneja, Sagarika and Hassan, Reham and Parquette, Jon R "pH-Responsive Rhodamine Nanotube Capable of Self-Reporting the Assembly State" ACS Applied Materials & Interfaces , v.16 , 2024 https://doi.org/10.1021/acsami.4c07280 Citation Details
Reardon, Thomas J. and Na, Baichuan and Parquette, Jon R. "Dissipative self-assembly of a proline catalyst for temporal regulation of the aldol reaction" Nanoscale , v.14 , 2022 https://doi.org/10.1039/D2NR03991E Citation Details
Sun, Yuan and Fry, Cathleen M. and Shieh, Aileen and Cai, Xiangchen and Reardon, Thomas J. and Parquette, Jon R. "Self-assembly of a 5-fluorouracil and camptothecin dual drug dipeptide conjugate" Organic & Biomolecular Chemistry , v.20 , 2022 https://doi.org/10.1039/d2ob00762b Citation Details

Please report errors in award information by writing to: awardsearch@nsf.gov.

Print this page

Back to Top of page