| NSF Org: |
EFMA Office of Emerging Frontiers in Research and Innovation (EFRI) |
| Recipient: |
|
| Initial Amendment Date: | August 28, 2020 |
| Latest Amendment Date: | October 14, 2020 |
| Award Number: | 2029249 |
| Award Instrument: | Standard Grant |
| Program Manager: |
Steven Peretti
speretti@nsf.gov (703)292-4201 EFMA Office of Emerging Frontiers in Research and Innovation (EFRI) ENG Directorate for Engineering |
| Start Date: | October 1, 2020 |
| End Date: | September 30, 2025 (Estimated) |
| Total Intended Award Amount: | $1,999,999.00 |
| Total Awarded Amount to Date: | $1,999,999.00 |
| Funds Obligated to Date: |
|
| History of Investigator: |
|
| Recipient Sponsored Research Office: |
4333 BROOKLYN AVE NE SEATTLE WA US 98195-1016 (206)543-4043 |
| Sponsor Congressional District: |
|
| Primary Place of Performance: |
4333 Brooklyn Ave NE Seattle WA US 98195-0001 |
| Primary Place of
Performance Congressional District: |
|
| Unique Entity Identifier (UEI): |
|
| Parent UEI: |
|
| NSF Program(s): | EFRI Research Projects |
| Primary Program Source: |
|
| Program Reference Code(s): | |
| Program Element Code(s): |
|
| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.041 |
ABSTRACT
Distributed manufacturing replaces large national facilities with smaller regional sites. It can relieve the stress on supply chains by shortening them. It also uses local resources more effectively. Microbes can convert local biomass into products. Their metabolic flexibility enables a wide variety of products to be made. It also offers the potential for rapid switching between products to meet local, regional, or national needs. The goal of this project is to create and demonstrate modular bioreactor technologies. These will allow repurposing of existing manufacturing facilities. They can be tuned to local biomass resources as well as specific products. The modular design will facilitate nimble responses to rapid shifts in demand and supply. Broad participation in research will strengthen the US bioeconomy.
Synthetic biology offers the means of producing a diverse array of high-value products from common biomass feedstocks. The goal of this project is to develop and integrate modular unit operations (e.g. continuous flow 3D-printed bioreactors) that will enable quick transitions from product to product in response to changing market needs. They will utilize common and locally available feedstocks and equipment. Transitions will be accomplished by exchange and/or re-configuration of modular reaction units. The project specifically targets the production of high-value natural medicines and drugs. The project team will integrate expertise in synthetic biology and metabolic engineering with recent materials innovations (e.g. 3D printed cell-laden bioreactors). The development of 3D-printed cell-laden hydrogel structures will permit continuous-flow operation and process intensification to facilitate transport processes, reduce reactor sizes and allow for re-configuration.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
Note:
When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external
site maintained by the publisher. Some full text articles may not yet be available without a
charge during the embargo (administrative interval).
Some links on this page may take you to non-federal websites. Their policies may differ from
this site.
Please report errors in award information by writing to: awardsearch@nsf.gov.
