Award Abstract # 2027908
RAPID: Collaborative: Transfer Learning Techniques for Better Response to COVID-19 in the US

NSF Org: CNS
Division Of Computer and Network Systems
Recipient: THE TRUSTEES OF PRINCETON UNIVERSITY
Initial Amendment Date: June 9, 2020
Latest Amendment Date: June 9, 2020
Award Number: 2027908
Award Instrument: Standard Grant
Program Manager: Ann Von Lehmen
CNS
 Division Of Computer and Network Systems
CSE
 Directorate for Computer and Information Science and Engineering
Start Date: June 15, 2020
End Date: May 31, 2021 (Estimated)
Total Intended Award Amount: $50,000.00
Total Awarded Amount to Date: $50,000.00
Funds Obligated to Date: FY 2020 = $50,000.00
History of Investigator:
  • Simon Levin (Principal Investigator)
Recipient Sponsored Research Office: Princeton University
1 NASSAU HALL
PRINCETON
NJ  US  08544-2001
(609)258-3090
Sponsor Congressional District: 12
Primary Place of Performance: Princeton University
Guyot Hall
Princeton
NJ  US  08544-1003
Primary Place of Performance
Congressional District:
12
Unique Entity Identifier (UEI): NJ1YPQXQG7U5
Parent UEI:
NSF Program(s): COVID-19 Research
Primary Program Source: 010N2021DB R&RA CARES Act DEFC N
Program Reference Code(s): 096Z, 7914
Program Element Code(s): 158Y00
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.070
Note: This Award includes Coronavirus Aid, Relief, and Economic Security (CARES) Act funding.

ABSTRACT

This project will use available data sets for COVID-19 in other countries, and in NYC, Virginia, and Maryland to build compartmental and metapopulation models to quantify the events that transpired there, and what interventions at various stages may have achieved. This will permit gaining control of future situations earlier. The epidemic models developed during this project will lead to innovations in computational epidemiology and enable approaches that mitigate the negative effects of COVID-19 on public health, society, and the economy.

Based on publicly available data sets for COVID-19 in other countries, and in NYC, Virginia, and Maryland, the researchers propose to build compartmental and metapopulation models to quantify the events that transpired there, understand the impacts of interventions at various stages, and develop optimal strategies for containing the pandemic. The basic model will subdivide the population into classes according to age, gender, and infectious status; examine the impact of the quarantine that was imposed; and then consider additional strategies that could have been imposed, in particular to reduce contact rates. The project will apply and extend the approach of "transfer learning" to this problem. The research team is well positioned to conduct this research; they have a long history of experience tracking and modeling infectious disease spread (e.g., Ebola, SARS) and are already participating in the CDC forecasting challenge for COVID-19.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Yagan, Osman and Sridhar, Anirudh and Eletreby, Rashad and Levin, Simon A. and Plotkin, Joshua B. and Poor, H. Vincent "Modeling and Analysis of the Spread of COVID-19 Under a Multiple-Strain Model with Mutations" Harvard Data Science Review , 2021 https://doi.org/10.1162/99608f92.a11bf693 Citation Details
Haghpanah, F and Lin, G and Levin, SA and Klein, E. "Analysis of the potential efficacy and timing of COVID-19 vaccine on morbidity and mortality" EClinicalMedicine , v.35 , 2021 Citation Details
Saad-Roy, Chadi M. and Grenfell, Bryan T. and Levin, Simon A. and Pellis, Lorenzo and Stage, Helena B. and van den Driessche, P. and Wingreen, Ned S. "Superinfection and the evolution of an initial asymptomatic stage" Royal Society Open Science , v.8 , 2021 https://doi.org/10.1098/rsos.202212 Citation Details
Saad-Roy, Chadi M. and Grenfell, Bryan T. and Levin, Simon A. and van den Driessche, P. and Wingreen, Ned S. "Evolution of an asymptomatic first stage of infection in a heterogeneous population" Journal of The Royal Society Interface , v.18 , 2021 https://doi.org/10.1098/rsif.2021.0175 Citation Details
Saad-Roy, Chadi M. and Levin, Simon A. and Metcalf, C. Jessica and Grenfell, Bryan T. "Trajectory of individual immunity and vaccination required for SARS-CoV-2 community immunity: a conceptual investigation" Journal of The Royal Society Interface , v.18 , 2021 https://doi.org/10.1098/rsif.2020.0683 Citation Details
Saad-Roy, Chadi M. and Morris, Sinead E. and Metcalf, C. Jessica and Mina, Michael J. and Baker, Rachel E. and Farrar, Jeremy and Holmes, Edward C. and Pybus, Oliver G. and Graham, Andrea L. and Levin, Simon A. and Grenfell, Bryan T. and Wagner, Caroline "Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes" Science , 2021 https://doi.org/10.1126/science.abg8663 Citation Details
Saad-Roy, Chadi M. and Morris, Sinead E. and Metcalf, C. Jessica and Mina, Michael J. and Baker, Rachel E. and Farrar, Jeremy and Holmes, Edward C. and Pybus, Oliver G. and Graham, Andrea L. and Levin, Simon A. and Grenfell, Bryan T. and Wagner, Caroline "Partial immunity and SARS-CoV-2 mutationsResponse" Science , v.372 , 2021 https://doi.org/10.1126/science.abi6719 Citation Details
Saad-Roy, Chadi M. and Wagner, Caroline E. and Baker, Rachel E. and Morris, Sinead E. and Farrar, Jeremy and Graham, Andrea L. and Levin, Simon A. and Mina, Michael J. and Metcalf, C. Jessica and Grenfell, Bryan T. "Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 years" Science , v.370 , 2020 https://doi.org/10.1126/science.abd7343 Citation Details
Wagner, Caroline E. and Prentice, Joseph A. and Saad-Roy, Chadi M. and Yang, Luojun and Grenfell, Bryan T. and Levin, Simon A. and Laxminarayan, Ramanan "Economic and Behavioral Influencers of Vaccination and Antimicrobial Use" Frontiers in Public Health , v.8 , 2020 https://doi.org/10.3389/fpubh.2020.614113 Citation Details
Wagner, Caroline E. and Saad-Roy, Chadi M. and Morris, Sinead E. and Baker, Rachel E. and Mina, Michael J. and Farrar, Jeremy and Holmes, Edward C. and Pybus, Oliver G. and Graham, Andrea L. and Emanuel, Ezekiel J. and Levin, Simon A. and Metcalf, C. Jess "Vaccine nationalism and the dynamics and control of SARS-CoV-2" Science , 2021 https://doi.org/10.1126/science.abj7364 Citation Details

PROJECT OUTCOMES REPORT

Disclaimer

This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.

The Collaborative RAPID project “Transfer Learning Techniques for Better Response to COVID-19” sought to understand how the COVID-19 pandemic evolved in various parts of the world, and to see if experiences in one region could lead to better intervention strategies in another region. We anticipate the release of open source datasets we have developed that would be of use to the broader research and academic communities. And in a more expansive way, we sought to comprehend long term COVID-19 dynamics.


In the execution of this project, we generated the following outcomes.

  • Our team has developed new AI-driven forecasting methods

  • We have developed new agent-based models to study the complicated issues arising in the study of COVID-19 dynamics

  • We have made significant progress in understanding the role of networks in reducing overall transmissions in a population

  • We have developed methods that can lead to improved forecasts for COVID-19 dynamics, and have shared these forecasts with the CDC as part of the forecasting hub initiative


The project has made the following lasting impacts on public health:

  • Our work has led to a better understanding of the role of networks in the transmission and control of epidemics, specifically herd immunity; our results shed new light on this important topic

  • We are continuing to support the CDC as they respond to the COVID-19 pandemic via participation in the Forecasting Hub and the Scenario Hub; results were briefed to the national COVID-19 task force

 


Last Modified: 09/26/2021
Modified by: Simon A Levin

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