Award Abstract # 2014141
Collaborative Research: International Physics of Living Systems Graduate Research Network

NSF Org: PHY
Division Of Physics
Recipient: WILLIAM MARSH RICE UNIVERSITY
Initial Amendment Date: September 16, 2021
Latest Amendment Date: March 5, 2025
Award Number: 2014141
Award Instrument: Continuing Grant
Program Manager: Krastan Blagoev
kblagoev@nsf.gov
 (703)292-4666
PHY
 Division Of Physics
MPS
 Directorate for Mathematical and Physical Sciences
Start Date: September 15, 2021
End Date: August 31, 2026 (Estimated)
Total Intended Award Amount: $2,859,845.00
Total Awarded Amount to Date: $2,782,999.00
Funds Obligated to Date: FY 2021 = $1,289,213.00
FY 2022 = $270,852.00

FY 2023 = $455,765.00

FY 2024 = $526,049.00

FY 2025 = $241,120.00
History of Investigator:
  • Jose Onuchic (Principal Investigator)
    jonuchic@rice.edu
Recipient Sponsored Research Office: William Marsh Rice University
6100 MAIN ST
Houston
TX  US  77005-1827
(713)348-4820
Sponsor Congressional District: 09
Primary Place of Performance: William Marsh Rice University
6100 Main St
Houston
TX  US  77005-1827
Primary Place of Performance
Congressional District:
09
Unique Entity Identifier (UEI): K51LECU1G8N3
Parent UEI:
NSF Program(s): Molecular Biophysics,
PHYSICS OF LIVING SYSTEMS,
Cross-BIO Activities
Primary Program Source: 01002122DB NSF RESEARCH & RELATED ACTIVIT
01002223DB NSF RESEARCH & RELATED ACTIVIT

01002324DB NSF RESEARCH & RELATED ACTIVIT

01002425DB NSF RESEARCH & RELATED ACTIVIT

01002526DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s): 068Z, 069Z, 1112, 1165, 6883, 7237, 7275, 7465, 7713, 8007, 8091, 9183
Program Element Code(s): 114400, 724600, 727500
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.049, 47.074

ABSTRACT

The international Physics of Living Systems (iPoLS) graduate research network (GRN) connects graduate students across the globe who are using methods and concepts of physical systems to unravel the mysteries of living dynamics. This inherently interdisciplinary field has undergone a tremendous growth over the past decade, partly as a result of community efforts such as the iPoLS graduate research network. This network enables the creation of coherent training programs, forums for peer-to-peer learning and information transfer, and provides support for efforts to grow the faculty and student numbers in this field at US universities. The current project will continue building the network in the US, and one of the major goals continues to be fostering communication and cooperation across national boundaries.

The PIs plan to use network resources to share best practices related both to education and into the building and support of a diverse community. They will present innovative plans for the recruitment of undergraduate interns from underrepresented groups, based on the successful experience of several of the network nodes. The PIs will collectively explore mechanisms for advocating for the unique capabilities of PoLS research and PoLS researchers to the broader biology and biomedicine communities, including the creation of PoLS-based sessions at major society meetings in cell biology, neuroscience, and fundamental cancer research.

This project is being jointly supported by the Physics of Living Systems program in the Division of Physics and the Molecular Biophysics Cluster in the Division of Molecular and Cellular Biosciences.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Bueno, Carlos and Liman, James and Schafer, Nicholas P. and Cheung, Margaret S. and Wolynes, Peter G. "A generalized Flory-Stockmayer kinetic theory of connectivity percolation and rigidity percolation of cytoskeletal networks" PLOS Computational Biology , v.18 , 2022 https://doi.org/10.1371/journal.pcbi.1010105 Citation Details
Chen, Xun and Jin, Shikai and Chen, Mingchen and Bueno, Carlos and Wolynes, Peter G. "The marionette mechanism of domaindomain communication in the antagonist, agonist, and coactivator responses of the estrogen receptor" Proceedings of the National Academy of Sciences , v.120 , 2023 https://doi.org/10.1073/pnas.2216906120 Citation Details
Dodero-Rojas, Esteban and Mello, Matheus F and Brahmachari, Sumitabha and Oliveira_Junior, Antonio B and Contessoto, Vinícius G and Onuchic, José N "PyMEGABASE: Predicting Cell-Type-Specific Structural Annotations of Chromosomes Using the Epigenome" Journal of Molecular Biology , v.435 , 2023 https://doi.org/10.1016/j.jmb.2023.168180 Citation Details
Gu, Xinyu and Schafer, Nicholas P. and Bueno, Carlos and Lu, Wei and Wolynes, Peter G. "A structural dynamics model for how CPEB3 binding to SUMO2 can regulate translational control in dendritic spines" PLOS Computational Biology , v.18 , 2022 https://doi.org/10.1371/journal.pcbi.1010657 Citation Details
Rowley, M. Jordan and Poulet, Axel and Nichols, Michael H. and Bixler, Brianna J. and Sanborn, Adrian L. and Brouhard, Elizabeth A. and Hermetz, Karen and Linsenbaum, Hannah and Csankovszki, Gyorgyi and Lieberman Aiden, Erez and Corces, Victor G. "Analysis of Hi-C data using SIP effectively identifies loops in organisms from C. elegans to mammals" Genome Research , v.30 , 2020 https://doi.org/10.1101/gr.257832.119 Citation Details
Sinha, Sumit and Li, Xin and Das, Rajsekhar and Thirumalai, D. "Mechanical feedback controls the emergence of dynamical memory in growing tissue monolayers" The Journal of Chemical Physics , v.156 , 2022 https://doi.org/10.1063/5.0087815 Citation Details

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