Award Abstract # 1950244
REU Site: Research Experiences for Undergraduates in Chemistry at the University of Cincinnati

NSF Org: CHE
Division Of Chemistry
Recipient: CINCINNATI UNIV OF
Initial Amendment Date: March 5, 2020
Latest Amendment Date: March 15, 2024
Award Number: 1950244
Award Instrument: Standard Grant
Program Manager: Tomislav Pintauer
tompinta@nsf.gov
 (703)292-7168
CHE
 Division Of Chemistry
MPS
 Directorate for Mathematical and Physical Sciences
Start Date: May 1, 2020
End Date: March 31, 2025 (Estimated)
Total Intended Award Amount: $364,000.00
Total Awarded Amount to Date: $364,000.00
Funds Obligated to Date: FY 2020 = $364,000.00
History of Investigator:
  • Anna Gudmundsdottir (Principal Investigator)
    anna.gudmundsdottir@uc.edu
  • Ruxandra Dima (Co-Principal Investigator)
Recipient Sponsored Research Office: University of Cincinnati Main Campus
2600 CLIFTON AVE
CINCINNATI
OH  US  45220-2872
(513)556-4358
Sponsor Congressional District: 01
Primary Place of Performance: University of Cincinnati Main Campus
Cincinnati
OH  US  45221-0172
Primary Place of Performance
Congressional District:
01
Unique Entity Identifier (UEI): DZ4YCZ3QSPR5
Parent UEI: DZ4YCZ3QSPR5
NSF Program(s): UNDERGRADUATE PROGRAMS IN CHEM
Primary Program Source: 01002021DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s): 9250
Program Element Code(s): 198600
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.049

ABSTRACT

This REU site award to the University of Cincinnati, located in Cincinnati, OH, supports a total of 28 students for 10 weeks during the summers from 2020-2022. This program, supported by the Division of Chemistry in the Mathematical and Physical Sciences Directorate, engages students in research projects spanning the field of chemistry. Students work on these projects, which are carefully designed for the 10-week timeline, under the guidance of faculty mentors. Alongside the hands-on research projects, students attend seminars and workshops to learn about current real-life scientific challenges such as ?Data Science for Big Data in Chemistry? and ?Sustainable Chemistry.? Students also take part in professional development activities, giving them the opportunity to develop as young professionals and researchers. Taken together, these activities prepare students to enter the STEM workforce as informed, knowledgeable professionals with a strong understanding of the challenges and opportunities before them.

The students engage in research projects spanning the field of chemistry, from solid-state photochemistry, to computational biochemistry, to biocompatible polymers, to electrocatalysis. The projects are designed for the 10-week timeline such that each student may advance scientific knowledge, including through refereed publications and a presentation at a suitable scientific meeting. Professional and skill development activities include workshops on reading scientific journals, creating individual professional development plans, and data science in chemistry. While this site is open to all, a focus on minority recruiting and the involvement of a faculty member from an HBCU (Historically Black Colleges and Universities) expands and strengthens diversity in the workforce.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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George, Sobiya and Govorov, Dmitrii and Gatlin, DeVonna M. and Merugu, Rajkumar and Wasson, Fiona J. and Shields, Dylan J. and Allen, Yasmine and Muthukrishnan, Sivaramakrishnan and Krause, Jeanette A. and Abe, Manabu and Gudmundsdottir, Anna D. "Light-Mediated Synthesis of 2-(4-Methoxyphenyl)-1-pyrroline via Intramolecular Reductive Cyclization of a Triplet Alkylnitrene" Organic Letters , v.25 , 2023 https://doi.org/10.1021/acs.orglett.3c01476 Citation Details
James, Brandi and Sriyarathne, H. Dushanee and Banerjee, Upasana and Henarath Mohottige, Wandana K. and Crabtree, Ben and León, Aliz and Hong, Miao and Tariq, Javeria and Alhayani, Taha and Abe, Manabu and Ault, Bruce S. and Gudmundsdottir, Anna D. "-Cleavage of 2,2-Diazido-2,3-dihydroinden-1-one in Solution and Cryogenic Matrices" The Journal of Organic Chemistry , 2024 https://doi.org/10.1021/acs.joc.4c00499 Citation Details
Kahawatte, Shehani and Macke, Amanda C and St_Clair, Carter and Dima, Ruxandra I "A Major Disease-Related Point Mutation in Spastin Dramatically Alters the Dynamics and Allostery of the Motor" Biochemistry , v.64 , 2025 https://doi.org/10.1021/acs.biochem.4c00693 Citation Details
Kissell, Lyndsay N. and Han, Daewoo and Vang, Der and Cikanek, Alexander W. and Steckl, Andrew J. and Strobbia, Pietro "Improved point-of-care detection of <i>P. gingivalis</i> using optimized surface-enhanced Raman scattering in lateral flow assays" Sensors & Diagnostics , 2024 https://doi.org/10.1039/D4SD00056K Citation Details
Macke, Amanda C. and Kelly, Maria S. and Varikoti, Rohith Anand and Mullen, Sarah and Groves, Daniel and Forbes, Clare and Dima, Ruxandra I. "Microtubule Severing Enzymes Oligomerization and Allostery: A Tale of Two Domains" The Journal of Physical Chemistry B , v.126 , 2022 https://doi.org/10.1021/acs.jpcb.2c05288 Citation Details
Macke, Amanda C. and Stump, Jacob E. and Kelly, Maria S. and Rowley, Jamie and Herath, Vageesha and Mullen, Sarah and Dima, Ruxandra I. "Searching for Structure: Characterizing the Protein Conformational Landscape with Clustering-Based Algorithms" Journal of Chemical Information and Modeling , v.64 , 2024 https://doi.org/10.1021/acs.jcim.3c01511 Citation Details
Ostertag, Blaise J. and Syeed, Ayah J. and Brooke, Alexandra K. and Lapsley, Kamya D. and Porshinsky, Evan J. and Ross, Ashley E. "Waste Coffee Ground-Derived Porous Carbon for Neurochemical Detection" ACS Sensors , v.9 , 2024 https://doi.org/10.1021/acssensors.3c02383 Citation Details
Varikoti, Rohith Anand and Fonseka, Hewafonsekage Yasan and Kelly, Maria S. and Javidi, Alex and Damre, Mangesh and Mullen, Sarah and Nugent, Jimmie L. and Gonzales, Christopher M. and Stan, George and Dima, Ruxandra I. "Exploring the Effect of Mechanical Anisotropy of Protein Structures in the Unfoldase Mechanism of AAA+ Molecular Machines" Nanomaterials , v.12 , 2022 https://doi.org/10.3390/nano12111849 Citation Details

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