Award Abstract # 1914787
Optimizing concentric ring electrode design for noninvasive electrophysiological measurement

NSF Org: EES
Div. of Equity for Excellence in STEM
Recipient: DINE COLLEGE
Initial Amendment Date: June 5, 2019
Latest Amendment Date: June 5, 2019
Award Number: 1914787
Award Instrument: Standard Grant
Program Manager: Jody Chase
lchase@nsf.gov
 (703)292-5173
EES
 Div. of Equity for Excellence in STEM
EDU
 Directorate for STEM Education
Start Date: September 1, 2019
End Date: August 31, 2023 (Estimated)
Total Intended Award Amount: $200,002.00
Total Awarded Amount to Date: $200,002.00
Funds Obligated to Date: FY 2019 = $200,002.00
History of Investigator:
  • Oleksandr Makeyev (Principal Investigator)
    omakeyev@dinecollege.edu
Recipient Sponsored Research Office: Dine College
1 CIRCLE DR
TSAILE
AZ  US  86556-9998
(928)724-6670
Sponsor Congressional District: 01
Primary Place of Performance: Dine College
AZ  US  86556-5000
Primary Place of Performance
Congressional District:
01
Unique Entity Identifier (UEI): KAAMMFK1JJL8
Parent UEI:
NSF Program(s): Tribal College & Univers Prog
Primary Program Source: 04001920DB NSF Education & Human Resource
Program Reference Code(s):
Program Element Code(s): 174400
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.076

ABSTRACT

The mission of the NSF Tribal Colleges and Universities Program (TCUP) is build the research and instructional capacity of education institutions serving Indigenous populations in the United States. The project, administered by Dine College and titled "Optimizing Concentric Ring Electrode Design for Noninvasive Electrophysiological Measurement", aligns well with the TCUP mission. The goal of this research project is to improve the design of concentric ring electrodes sensors (CRE), which are used in biomedical technology to monitor the health of living tissues. The research strives to boost the accuracy of the technology in detecting electrical signals from tissue, which can then be applied to improve doctors' ability to diagnose their patients' conditions. This project builds on and expands the primary research direction of the Mathematics for Engineering Applications laboratory (MEA lab) at Dine College. Through the paid undergraduate research assistant positions with the MEA lab the project provides, it also supports the mission of the college to deliver robust learning opportunities for students.

This research focus is important because the ability to estimate the surface Laplacian at each electrode constitutes the primary biomedical significance of CREs. Further improvement of the accuracy of Laplacian estimation via optimal CRE designs may contribute to the advancement of numerous noninvasive electrophysiological measurement systems that currently use CREs to acquire diagnostic electrical signals from the brain, intestines, heart or uterus, for example. The goal of this research project will be achieved by 1) expanding the solutions of the general inter-ring distances optimization problem for a wide range of conditions, and 2) incorporating the radius of the central disc and individual widths of the concentric rings into the CRE design optimization process along with the currently included parameters such as the number of rings and inter-ring distances.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Garcia-Casado, Javier and Ye-Lin, Yiyao and Prats-Boluda, Gema and Makeyev, Oleksandr "Evaluation of Bipolar, Tripolar, and Quadripolar Laplacian Estimates of Electrocardiogram via Concentric Ring Electrodes" Sensors , v.19 , 2019 10.3390/s19173780 Citation Details
Liu, Xiang and Makeyev, Oleksandr and Besio, Walter "Improved Spatial Resolution of Electroencephalogram Using Tripolar Concentric Ring Electrode Sensors" Journal of Sensors , v.2020 , 2020 10.1155/2020/6269394 Citation Details
Makeyev, Oleksandr and Lee, Alana and Begay, Ashton "Solving the Inter-Ring Distances Optimization Problem for Pentapolar and Sextopolar Concentric Ring Electrodes Based on the Negligible Dimensions Model of the Electrode" Engineering Proceedings , v.10 , 2021 https://doi.org/10.3390/ecsa-8-11280 Citation Details
Makeyev, Oleksandr and Musngi, Mark and Moore, Larry and Ye-Lin, Yiyao and Prats-Boluda, Gema and Garcia-Casado, Javier "Validating the Comparison Framework for the Finite Dimensions Model of Concentric Ring Electrodes Using Human Electrocardiogram Data" Applied Sciences , v.9 , 2019 10.3390/app9204279 Citation Details
Makeyev, Oleksandr and Ye-Lin, Yiyao and Prats-Boluda, Gema and Garcia-Casado, Javier "Comparing Optimal and Commercially Available Bipolar and Tripolar Concentric Ring Electrode Configurations Using Finite Element Method Modeling Based on Their Finite Dimensions Models" , 2022 https://doi.org/10.1109/SAS54819.2022.9881246 Citation Details
Makeyev, Oleksandr and Ye-Lin, Yiyao and Prats-Boluda, Gema and Garcia-Casado, Javier "Comprehensive Optimization of the Tripolar Concentric Ring Electrode Based on Its Finite Dimensions Model and Confirmed by Finite Element Method Modeling" Sensors , v.21 , 2021 https://doi.org/10.3390/s21175881 Citation Details
Makeyev, Oleksandr and Ye-Lin, Yiyao and Prats-Boluda, Gema and Garcia-Casado, Javier "Finite element method modeling to confirm the results of comprehensive optimization of the tripolar concentric ring electrode based on its finite dimensions model" 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) , 2021 https://doi.org/10.1109/EMBC46164.2021.9629784 Citation Details

PROJECT OUTCOMES REPORT

Disclaimer

This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.

Over the course of this award PI’s Mathematics for Engineering Applications (MEA) research laboratory produced four journal papers in peer-reviewed journals with good impact factors as well as four conference proceedings papers and four abstracts/posters. This included four of PI’s undergraduate research assistants becoming co-authors on publications including journal papers. Two of them traveled to present their research despite of the pandemic and one of them made three in person poster presentations with another two accepted for presentation early next year. Finally, support from this award made possible preparation, submission, and/or revision of two patent applications one of which was already issued in June 2021 as the first ever patent not only for Diné College but, to the best of PI’s knowledge, for any tribal college or university.

The major goal of this project was to optimize the design of concentric ring electrodes, novel sensors gaining increased recognition in the area of noninvasive electrophysiological measurement for diagnostic purposes. More specifically, this project provided an innovative solution (ability to optimize all of the parameters of the concentric ring electrode simultaneously) to improve the accuracy of an acquired signal (surface Laplacian estimate) to inform future sensor design decisions. This was accomplished by successfully fulfilling two specific aims: 1) expanding the solutions of the previously proposed general inter-ring distances optimization problem for a wide range of conditions and 2) incorporating the radius of the central disc and individual widths of the concentric rings (the last two parameters that were previously not included into the concentric ring electrode model used for optimization purposes) into the concentric ring electrode design optimization process along with the previously included parameters such as the number of rings and inter-ring distances. Specifically, for the first specific aim, the inter-ring distances optimization problem has been solved for pentapolar (4 rings) and sextopolar (5 rings) concentric ring electrode configurations using a wide range of truncation error percentiles ranging from 1st to 25th. Moreover, previously obtained solutions for tripolar (2 rings) and quadripolar (3 rings) configurations have been expanded to cover the same percentile range. Finally, a way to estimate the optimal ranges of inter-ring distances for electrode configurations with 6 or more rings was proposed and illustrated using septapolar (6 rings) configuration as an example. For the second specific aim, a realistic finite dimensions model of the concentric ring electrode was proposed as opposed to the previously used simplistic negligible dimensions model. It was also used as a basis for solving a comprehensive electrode design optimization problem with resulting optimal configurations constituting the bulk of the issued patent. These optimal configurations were directly compared to both the previously proposed configurations and to the models approximating the dimensions of the currently available commercial bipolar (1 ring) and tripolar concentric ring electrodes. The advantage of the optimal configurations with respect to the accuracy of the Laplacian estimation was confirmed using finite element method modeling. All of these results have been successfully disseminated via the aforementioned publications.

MEA lab’s intellectual merit of contributing to advancing post-secondary learning goes beyond paid research assistantships that provide students with cutting edge research experience. MEA lab also provides STEM tutoring to current Diné College students (both undergraduate and graduate) and promotes STEM disciplines to prospective ones via participation in biannual STEM festivals. During these festivals MEA lab members introduce visiting high-school students to electric circuits by building models of renewable energy power plants.

Broader impacts of MEA lab go beyond adding to the publications record and intellectual property portfolio of the School of STEM. Thanks to this award, MEA lab continued establishing itself as one of the primary research hubs of Diné College as well as one of the leading laboratories working with concentric ring electrode technology in the world.

 


Last Modified: 12/23/2023
Modified by: Oleksandr Makeyev

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