| NSF Org: |
EFMA Office of Emerging Frontiers in Research and Innovation (EFRI) |
| Recipient: |
|
| Initial Amendment Date: | July 24, 2018 |
| Latest Amendment Date: | March 9, 2023 |
| Award Number: | 1830968 |
| Award Instrument: | Standard Grant |
| Program Manager: |
Manju Hingorani
mhingora@nsf.gov (703)292-7323 EFMA Office of Emerging Frontiers in Research and Innovation (EFRI) ENG Directorate for Engineering |
| Start Date: | September 1, 2018 |
| End Date: | February 28, 2026 (Estimated) |
| Total Intended Award Amount: | $1,999,750.00 |
| Total Awarded Amount to Date: | $2,583,356.00 |
| Funds Obligated to Date: |
FY 2019 = $99,830.00 FY 2020 = $154,955.00 FY 2021 = $108,923.00 FY 2022 = $109,928.00 FY 2023 = $109,970.00 |
| History of Investigator: |
|
| Recipient Sponsored Research Office: |
633 CLARK ST EVANSTON IL US 60208-0001 (312)503-7955 |
| Sponsor Congressional District: |
|
| Primary Place of Performance: |
2145 Sheridan Road Evanston IL US 60208-3107 |
| Primary Place of
Performance Congressional District: |
|
| Unique Entity Identifier (UEI): |
|
| Parent UEI: |
|
| NSF Program(s): |
Genetic Mechanisms, EWFD-Eng Workforce Development, GOALI-Grnt Opp Acad Lia wIndus, EFRI Research Projects |
| Primary Program Source: |
01002324DB NSF RESEARCH & RELATED ACTIVIT 01001819DB NSF RESEARCH & RELATED ACTIVIT 01001920DB NSF RESEARCH & RELATED ACTIVIT 01002021DB NSF RESEARCH & RELATED ACTIVIT 01002122DB NSF RESEARCH & RELATED ACTIVIT |
| Program Reference Code(s): |
|
| Program Element Code(s): |
|
| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.041 |
ABSTRACT
It is now possible to reprogram blood cells into cells that can become a variety of cell types for specific tissues and organs. Cells can open up their genes to become more adaptable to stresses, a trick that cancer cells often use to evade the effects of chemotherapy. Developing technologies that can control the reprogramming can benefit a huge number of people. This project will build the foundations for a new technology that will power regenerative medicine by converting knowledge learned during this research into tools that are expected to improve the survival of cells in low oxygen conditions and promote their regeneration, for example nerve cells after a stroke and heart cells after a heart attack.
The adaptive potential of multicellular organisms is critically determined by their capacity to create and employ new behaviors in response to stress. This process depends on the encoded information within the cellular population, both at the genetic, epigenetic, and transcriptional levels. The proposed research will provide new knowledge and strategies to regulate chromatin structure in order to enhance the adaptive potential of eukaryotic cells with the ultimate goal of facilitating tissue regeneration and function. The PI will investigate how to control chromatin structure via pharmacological agents, morphological cues, and low frequency electromagnetic radiation. The proposed research will create a paradigm shift for tissue and regenerative engineering strategies by elucidating factors that govern the restriction of the adaptive potential of eukaryotic cells. Upon completion of the proposal it is expected to: 1) develop a new nanoscale imaging technology to image nanoscale chromatin modifications in vivo; 2) bridge nanoscale imaging and molecular assays; and 3) reversibly increase adaptability of otherwise terminally differentiated cells.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
Note:
When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external
site maintained by the publisher. Some full text articles may not yet be available without a
charge during the embargo (administrative interval).
Some links on this page may take you to non-federal websites. Their policies may differ from
this site.
Please report errors in award information by writing to: awardsearch@nsf.gov.
