Award Abstract # 1827066
RCN-UBE: Cell Biology Education Consortium

NSF Org: DBI
Division of Biological Infrastructure
Recipient: OUACHITA BAPTIST UNIVERSITY
Initial Amendment Date: August 14, 2018
Latest Amendment Date: August 14, 2018
Award Number: 1827066
Award Instrument: Standard Grant
Program Manager: Amanda Simcox
asimcox@nsf.gov
 (703)292-8165
DBI
 Division of Biological Infrastructure
BIO
 Directorate for Biological Sciences
Start Date: August 15, 2018
End Date: July 31, 2024 (Estimated)
Total Intended Award Amount: $500,000.00
Total Awarded Amount to Date: $500,000.00
Funds Obligated to Date: FY 2018 = $500,000.00
History of Investigator:
  • Nathan Reyna (Principal Investigator)
    reynan@obu.edu
  • Lori Hensley (Co-Principal Investigator)
Recipient Sponsored Research Office: Ouachita Baptist University
410 OUACHITA ST
ARKADELPHIA
AR  US  71998-0001
(870)245-5528
Sponsor Congressional District: 04
Primary Place of Performance: Ouachita Baptist University
AR  US  71998-0001
Primary Place of Performance
Congressional District:
04
Unique Entity Identifier (UEI): LJWHZTMJHQZ6
Parent UEI: LJWHZTMJHQZ6
NSF Program(s): UBE - Undergraduate Biology Ed,
IUSE,
EPSCoR Co-Funding
Primary Program Source: 04001819DB NSF Education & Human Resource
01001819DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s): 9150
Program Element Code(s): 037Y00, 199800, 915000
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.074

ABSTRACT

The need for changing how the natural sciences are taught and the expansion of undergraduate research experiences has been well-documented in the literature. One mechanism to accomplish these changes is the incorporation of course-based undergraduate research experiences. While isolated groups are introducing cell culture techniques into such experiences, there has been no coordinated effort to compile resources and provide training that makes creating customizable cell-culture-based research projects easier to implement at smaller, primarily undergraduate institutions and community colleges where faculty time and resources are limited. The Cell Biology Education Coalition (CBEC) will address these major shortfalls through the creation of a network of faculty, students, and resources that will provide an infrastructure to facilitate the development and implementation of unique student-driven research experiences. By creating projects that align with a curriculum's learning goals and desired student outcomes, these activities will help strengthen critical thinking skills in and beyond the classroom.

The primary activity of CBEC will be the development of "Cell Blocks," modules consisting of written and video protocols and classroom implementation strategies and assessments. Cell Blocks will be developed by faculty and their students at small institutions making it likely that they will be adaptable at similar schools. Because the Cell Blocks will have similar basic components, they will be able to be mixed and matched to answer novel questions. The implementation of multiple Cell Blocks will serve as the basis for semester-long research projects that provide the foundation for independent student research projects. Network faculty will have opportunities for professional development through the creation of new Cell Blocks, access to all Cell Block modules and associated supplies, and networking opportunities. Students will be able to interact within a community of scientists to expand on their experiences and create their own independent research projects, establish a funding record through a voucher system, and participate in professional development experiences. Such activities have the potential to increase the number of students entering STEM research fields at the graduate level and in the workforce. Additionally, because efforts will be made to recruit faculty from minority-serving institutions, the proposed network will have a pronounced effect on undergraduates underrepresented in STEM.

This project is being jointly funded by the Directorate for Biological Sciences, Division of Biological Infrastructure, and the Directorate for Education and Human Resources, Division of Undergraduate Education as part of their efforts to address the challenges posed in Vision and Change in Undergraduate Biology Education: A Call to Action (http://visionandchange/finalreport/). Co-funding was provided by the Established Program to Stimulate Competitive Research (EPSCoR).

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Sabel, Jaime L. and Wright, Kendra and Adler, Jacob J. and Bates, Gary and Bates, LaShall and Pandey, Sumali and Simons, Amanda M. and Swerdlow, Sarah J. and Reyna, Nathan S. and Hensley, Lori "Transitioning Cell Culture CURE Labs from Campus to Online: Novel Strategies for a Novel Time " Journal of Microbiology & Biology Education , v.22 , 2021 https://doi.org/10.1128/jmbe.v22i1.2619 Citation Details
Barnes, C.N. "Gene Expression and Data Analysis Pipeline Using Cancer BioPortal in the Classroom" Journal of microbiology biology education , v.22 , 2021 https://doi.org/10.1128/jmbe.v22i1.2315 Citation Details
Jacob Adler "Fatty Acid Induction of Lipid Droplets in Cancer Cells" CourseSource , v.10 , 2023 Citation Details
Johnson, Kristen C. and Sabel, Jaime L. and Cole, Judith and Pruett, Christin L. and Plymale, Ruth and Reyna, Nathan S. "From genetics to biotechnology: Synthetic biology as a flexible courseembedded research experience" Biochemistry and Molecular Biology Education , v.50 , 2022 https://doi.org/10.1002/bmb.21662 Citation Details
Todorova, Valentina K. and Byrum, Stephanie D. and Gies, Allen J. and Haynie, Cade and Smith, Hunter and Reyna, Nathan S. and Makhoul, Issam "Circulating Exosomal microRNAs as Predictive Biomarkers of Neoadjuvant Chemotherapy Response in Breast Cancer" Current Oncology , v.29 , 2022 https://doi.org/10.3390/curroncol29020055 Citation Details
Sharma, Krishna D. and Schaal, Danielle and Kore, Rajshekhar A. and Hamzah, Rabab N. and Pandanaboina, Sahitya Chetan and Hayar, Abdallah and Griffin, Robert J. and Srivatsan, Malathi and Reyna, Nathan S. and Xie, Jennifer Yanhua "Glioma-derived exosomes drive the differentiation of neural stem cells to astrocytes" PLOS ONE , v.15 , 2020 https://doi.org/10.1371/journal.pone.0234614 Citation Details
Justin McGee, Cyntanna Hawkins "Evaluating PC12 Cell Differentiation Following Exosome Treatments" Proceedings of The National Conference On Undergraduate Research (NCUR) 2019 Kennesaw State University Kennesaw, Georgia April 11-13, 2019 , 2019 Citation Details
Lipscomb, Jackson and Gray, Kassidy and Melton, Tuesday and Nelson, Parker and Rye, Alyssa and Pruett, Christin L and Reyna, Nathan S "miR-127/3p Inhibits Cell Migration in Lung Adenocarcinoma Under Hypoxic and Normal Oxygen Conditions" microPublication biology , v.2024 , 2024 https://doi.org/10.17912/micropub.biology.001355 Citation Details
Reyna, Nathan S. and Pruett, Christin and Morrison, Mike and Fowler, Jennifer and Pandey, Sumali and Hensley, Lori "Twitter: More than Tweets for Undergraduate Student Researchers" Journal of Microbiology & Biology Education , v.23 , 2022 https://doi.org/10.1128/jmbe.00326-21 Citation Details

PROJECT OUTCOMES REPORT

Disclaimer

This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.

The Cell Biology Education Consortium (CBEC) has emerged as a transformative force in undergraduate biology education, emphasizing experiential learning through customizable cell culture modules known as Cell Blocks. The consortium’s mission centers on enhancing course-based undergraduate research experiences (CUREs) through the development of an infrastructure that supports the integration of research into the classroom. The key objectives include creating a network of faculty committed to enhancing cell biology education, developing innovative research projects, providing robust training and support systems, and ensuring that resources created are widely disseminated across participating institutions.

 The primary goal of CBEC is to facilitate the creation of a series of plug-and-play customizable cell culture modules (Cell Blocks) that can be readily adapted for various educational settings. These Cell Blocks are designed to create CUREs that engage students in authentic research experiences suitable for diverse learning environments. An essential aspect of this initiative is providing funding through a voucher system, which allocates resources for faculty and students to implement these hands-on research projects effectively. Current initiatives also prioritize the dissemination of information about the resources developed under the CBEC umbrella.

Underpinning these goals are significant accomplishments that demonstrate the impact of CBEC initiatives. Currently, CBEC has registered 235 faculty members, primarily from undergraduate institutions, and has funded 32 PUI institutions. More than 800 students have utilized CBEC materials in both classroom settings and research labs, demonstrating the consortium's broad reach. Notably, faculty and students have developed 45 unique Cell Blocks, providing structured pathways for research and learning in cell biology.

One of the notable activities undertaken by CBEC was the establishment of a faculty working group, which facilitated the implementation of the full CBEC Cell Culture CURE. This activity had previously been delayed due to the COVID-19 pandemic, yet six institutions successfully conducted a similar CURE, showcasing the collaborative spirit of the consortium. Furthermore, partnerships with companies such as Sampling Human have allowed thirteen faculty members to test innovative cell culture assays designed to replace more traditional methods.

The accomplishments of CBEC extend beyond institutional collaboration. Faculty members from the consortium have actively disseminated their findings through various conferences, over 100 student posters acknowledging the CBEC has been presented at 18 national or regional conferences. These conferences have provided invaluable platforms for presenting research, sharing best practices, and networking with colleagues across institutions. Additionally, at least 7 peer-reviewed publications have emerged from the collaborative efforts of CBEC faculty and students, contributing meaningfully to the body of knowledge in cell biology education.

One of the highlights of the consortium's outreach efforts has been its YouTube channel, which hosts instructional videos and research results related to the Cell Blocks. Since the channel's inception, its videos have received approximately 90,000 views, highlighting the channel’s role in enhancing accessibility to educational materials. Each video averages an engaging five minutes in length, making them suitable for both quick learning and detailed understanding.

The development and implementation of Cell Blocks stand as a cornerstone of the CBEC’s initiatives, with over 70 distinct protocols created by students to date. These protocols enable students to design their experiments, fostering a sense of ownership and engagement in their learning processes. This structured yet flexible approach to undergraduate research has transformed traditional classroom environments into vibrant laboratories of inquiry, where students actively contribute to scientific discovery.

The impact of CBEC activities extends into student engagement beyond the classroom. The integration of research components into courses has reinvigorated student interest in cell biology, creating a more compelling academic environment. Reports indicate that students have expressed excitement about participating in genuine research rather than adhering to traditional cookbook-style laboratory exercises. Faculty members have noted a shift towards a more relaxed teaching style, where they can trust students to navigate research challenges, ultimately promoting deeper learning and critical thinking.

 CBEC continues to offer robust training and professional development opportunities for faculty. Regular virtual meetings serve as a forum for addressing challenges and sharing insights. CBEC faculty meets regularly to refine their approaches and enhance collaborative efforts.

The professional development initiatives have empowered faculty, with many reporting improved teaching practices and learning outcomes as a direct result of their involvement with CBEC. CBEC leadership has provided support material for multiple faculty tenure and promotions. The CBEC has writen letters of collaboration for faculty submitting NSF grants of thier own. In addtion, the principal investigator of the CBEC, received the Inaugural Innovation in Education Award from the American Society for Cell Biology, a recognition of the significant impact that CBEC initiatives have had on undergraduate education and student driven research.

 


Last Modified: 11/20/2024
Modified by: Nathan S Reyna

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