| NSF Org: |
TI Translational Impacts |
| Recipient: |
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| Initial Amendment Date: | February 4, 2013 |
| Latest Amendment Date: | July 17, 2014 |
| Award Number: | 1256626 |
| Award Instrument: | Standard Grant |
| Program Manager: |
Muralidharan Nair
TI Translational Impacts TIP Directorate for Technology, Innovation, and Partnerships |
| Start Date: | February 15, 2013 |
| End Date: | January 31, 2016 (Estimated) |
| Total Intended Award Amount: | $499,869.00 |
| Total Awarded Amount to Date: | $643,866.00 |
| Funds Obligated to Date: |
FY 2014 = $28,000.00 |
| History of Investigator: |
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| Recipient Sponsored Research Office: |
500 SIMMON DR OSCEOLA WI US 54020-5844 (651)213-6185 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
207 Pleasant St SE Minneapolis MN US 55455-0240 |
| Primary Place of
Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): |
STTR Phase II, SBIR Phase II |
| Primary Program Source: |
01001415DB NSF RESEARCH & RELATED ACTIVIT |
| Program Reference Code(s): |
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| Program Element Code(s): |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.084 |
ABSTRACT
This Small Business Innovation Research (SBIR) Phase II project addresses the analysis needs for monitoring perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in water. PFOA and PFOS are ubiquitous environmental contaminants that have been found at low concentrations in waste water, drinking water, human blood, and in food. Because PFOA, PFOS and other perfluorochemicals are bio-accumulative, extremely persistent, and toxic, several states have established analytical methods and emission limits. Furthermore, there is a large effort surrounding remediation of PFOA and PFOS contaminated areas. Considering the impacts on both the environment and public health, there is a market need for rapid, selective, low cost, and field portable PFOA and PFOS sensing. This research aims at the development of a field deployable ion-selective electrode that permits selective and fast measurement of PFOA and PFOS with a low detection limit at low cost.
The broader impact of this research is to improve public health by rapid identification and screening of polluted areas. Moreover, the research will enable an economical PFOS/PFOA detection method for environmental monitoring, continued research, compliance and remediation efforts. Currently, research efforts are hampered by costly and time consuming liquid extractions coupled with liquid chromatography and mass spectrometry. This research aims to produce a device that will significantly lower the barriers to testing. Additional broader impacts include expanded application of the sensor to measure the contaminant in blood, soil and food. Most importantly, these efforts are important and instructive to direct and monitor remediation and enable in-field research. We view this effort as an integral part of a wider effort to understand and reduce sources and pathways by which the persistent substance has become widespread in the environment.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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PROJECT OUTCOMES REPORT
Disclaimer
This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.
Perfluorinated compounds (PFCs), are emerging and ubiquitous environmental contaminants that have been found at low concentrations in waste water, surface water, soil, and animal tissues. Because they are bio-accumulative, extremely persistent and toxic, several states have established analytical methods and emission limits. Furthermore, there is a huge effort surrounding remediation of PFCs contaminated areas. Considering the impacts on both the environment and public health, an acute need for rapid, selective, low cost, and field portable PFCs sensing. Although there are established LC/MS/MS methods to measure PFCs at low levels, the methods are tedious and the equipments are expensive and are not field portable.
In this SBIR phase II project, we aim at development and validation of a field deployable sensing system for rapid and selective detection of PFCs. The outcomes of this work are as follow:
1. We have optimized solid contact reference electrodes by introducing a Co(II)/Co(III) redox couple into the sensing membranes for better reproducibility of E0 values. This work has been published in Electroanalysis, 2015.
2. We have established a method to prescreen water samples for PFOS contamination. We are able to indicate “Y/N” PFOS in water sample (compared to PFOS threshold concentration of 0.02 ppb) and evaluate the concentration of PFOS. More specifically, we have made progresses in the following aspects:
1) We developed and optimized a single liquid junction reference electrode with small size based on gel.
2) We developed miniaturized PFOS sensors.
3) We developed a procedure to pre-concentrate PFOS from water sample and extract based on solid phase extraction (SPE).
4) We determined the recovery of extraction based on solid phase extraction (SPE) in different concentration ranges of PFOS and used it to provide quantitative data;
3. We evaluated the sensors’ performance, including accuracy, precision, limit of detection and limit of quantification.
4. We validated our data obtained with PFOS sensor with data obtained from LC/MS provided by an analytical lab for the Air Force.
Last Modified: 02/02/2016
Modified by: Chunze Lai
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