Award Abstract # 1200180
Collaborative Research: Engineering Design of Oxygen Rich Surfaces for Bioelectrodes

NSF Org: CMMI
Division of Civil, Mechanical, and Manufacturing Innovation
Recipient: CLARKSON UNIVERSITY
Initial Amendment Date: August 23, 2012
Latest Amendment Date: August 23, 2012
Award Number: 1200180
Award Instrument: Standard Grant
Program Manager: Alexis Lewis
alewis@nsf.gov
 (703)292-2624
CMMI
 Division of Civil, Mechanical, and Manufacturing Innovation
ENG
 Directorate for Engineering
Start Date: September 1, 2012
End Date: August 31, 2016 (Estimated)
Total Intended Award Amount: $202,725.00
Total Awarded Amount to Date: $202,725.00
Funds Obligated to Date: FY 2012 = $202,725.00
History of Investigator:
  • Emanuela Andreescu (Principal Investigator)
    eandrees@clarkson.edu
Recipient Sponsored Research Office: Clarkson University
8 CLARKSON AVE
POTSDAM
NY  US  13676-1401
(315)268-6475
Sponsor Congressional District: 21
Primary Place of Performance: Clarkson University
8 Clarkson Avenue
Potsdam
NY  US  13676-1401
Primary Place of Performance
Congressional District:
21
Unique Entity Identifier (UEI): SL2PF6R7MRN1
Parent UEI:
NSF Program(s): MATERIALS AND SURFACE ENG
Primary Program Source: 01001213DB NSF RESEARCH & RELATED ACTIVIT
Program Reference Code(s): 022E, 1444, 8021, 9102, AMPP
Program Element Code(s): 163300
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.041

ABSTRACT

The research objective of this grant is to elucidate the fundamental processes of the oxygen transport, permeability, and release in porous, metal oxide supported biofunctionalized membranes, as materials for bioelectrodes and biofuel cells. The research project will study the catalytic, redox, and oxygen storage and release properties of metal doped and mixed metal oxides within a porous tridimensional network that will be used to fabricate "oxygen-rich" surfaces that are able to operate under physiological and ambient temperature conditions. A suite of spectroscopic, electrochemical, and scanning electrochemical microscopy methods will be used to facilitate understanding of the oxygen transport mechanism at the enzyme/doped metal oxide interface in the porous layer and to establish correlations between composition, morphology, and corresponding bioelectrocatalytic performance. This research will improve oxygen availability and permeability at surfaces, enhancing the overall performance of bioelectrodes.

If successful, this interdisciplinary collaborative effort will enable development of a new generation of materials and surfaces that can be used in oxygen restrictive conditions. This research introduces a unique technology in the field of bioelectrochemistry and biofuel cells for facilitating oxygen mobility and providing storage/release capabilities. This research project will promote innovation and development of critical thinking skills in all aspects of student training to develop a foundation of knowledge that will enable future discoveries. Graduate and undergraduate students, especially minorities and women, will participate in this research. K12 students and teachers will be exposed to this research through established mechanisms at the two collaborating institutions.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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A. Karimi, A. Othman, A., Uzunoglu, L. Stanciu, S. Andreescu "Graphene based Enzymatic Bioelectrodes and Biofuel Cells" Nanoscale , 2015 , p.6909-6923 10.1039/C4NR07586B
A. Othman, A. Karimi, S. Andreescu "Functional Nanostructures for Enzyme based Biosensors: Properties, Fabrication and Applications" J. Mater. Chem B , 2016 DOI: 10.1039/C6TB02009G
A. Uzunoglu, H. Zhang, S. Andreescu, L. Stanciu "CeO2 ?MO x (M: Zr, Ti, Cu) mixed metal oxides with enhanced oxygen storage capacity" J. Mater Sci. , v.15 , 2015 , p.3750-3762
Daniel Andreescu, Gonca Bulbul, Rifat E. Ozel, Akhtar Hayat, Naimish Sardesai, Silvana Andreescu "Applications and Implications of Nanoceria Reactivity: Measurement Tools and Environmental Impact" Environmental Science: Nano , v.1 , 2014 , p.445-458 DOI: 10.1039/C4EN00075G
E. R. Ozel, A. Hayat, S. Andreescu "Recent Developments in Electrochemical Sensors for the Detection of Neurotransmitters for Applications in Biomedicine" Analytical letters , v.47 , 2014 , p.1044-1069 10.1080/00032719.2014.976867
N.P. Sardesai, A. Karimi, S. Andreescu, "Engineered Pt doped nanoceria for oxidase based bioelectrodes operating in oxygen deficient environment" ChemElectrocChem , v.1 , 2014 , p.2082-2088 10.1002/celc.201402250
N.P. Sardesai, M. Ganesana, A. Karimi, JC. Leiter, S. Andreescu "Platinum-Doped Ceria Based Biosensor for in Vitro and in Vivo Monitoring of Lactate during Hypoxia" Analytical Chemistry , 2015 , p.2996-3003 10.1021/ac5047455
Rfat Emrah Özel, Cristina Ispas, Mallikarjunarao Ganesana, J.C. Leiter, Silvana Andreescu "Glutamate oxidase biosensor based on mixed ceria and titania nanoparticles for the detection of glutamate in hypoxic environments" Biosensors and Bioelectronics , v.52 , 2014 , p.397

PROJECT OUTCOMES REPORT

Disclaimer

This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.

"This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content."

This project focused on the development and characterization of microporous surfaces of mixed ceria based oxides with enhanced catalytic and oxygen transport properties for improving performance of enzyme based bioelectrodes and biofuel cells. The overall goal was to fabricate microporous oxygen-rich materials, study their surface properties and implement them in the construction of bioelectrodes and biofuel cells. The project also included activities to develop educational materials for graduate and upper level undergraduate students to train them in material characterization, biofunctionalization and biodevice engineering. Several undergraduates and two K12 teachers participated in research and were exposed to materials science and engineering principles.

The research demonstrated the potential of nanostructured ceria based oxides as functional materials for enzyme based bioelectrodes and biofuel cells. Several strategies were designed to fabricate microporous oxygen-rich materials based on cerium oxides including the use of bare, mixed and doped nanoparticles, as well as tridimensional nanocomposite networks. Research demonstrated that hybrid nanocomposites with ceria nanoparticles embedded within conductive polymeric layers and high surface area carbon based nanostructures provide significant capabilities for enhancing performance of biocathodes and biofuels cells. Pt-ceria nanostructures deposited on graphene or microporous carbon-based bucky paper demonstrated high activity for bioelectrocatalytic reduction of oxygen and the construction of laccase bioelectrodes and biofuel cells. Bioelectrodes constructed with ceria and Pt-doped ceria enabled sensitive detection of physiological levels of glucose and lactate. The oxygen release properties of these materials have enabled functionality of enzyme based bioelectrodes in oxygen limited conditions. Therefore, these materials can be used to improve oxygen availability at surfaces, thus minimizing oxygen dependency and enhancing the overall performance of enzyme electrodes and potentially of other devices in which oxygen is a restrictive factor. They can also be used as a general platform for the immobilization of enzymes for a variety of biosensing, biofuel cells and bioelectronics applications.


The project provided ample opportunities for graduate and undergraduate student training in chemistry, material science and device engineering. Experiments to demonstrate the use of electrochemistry to characterize surfaces and interfaces and to illustrate the use of functional nanostructures for enzyme immobilization have been introduced in Spectroscopy and Biochemistry/Biotechnology lectures and laboratory courses at Clarkson. One postdoctoral fellow, three graduate students (1 female) and 3 undergraduates (2 female) participated in project activities. One graduate student successfully defended his thesis and has secured an industrial position. A female graduate student has received a travel award to present this research at a national meeting. Research findings have been disseminated to the local community through posters and presentations to local ACS, graduate and undergraduate conferences. Broader dissemination has been accomplished through several publications in highly ranked materials and electrochemistry journals including: Nanoscale, ChemElectroChem, Analytical Chemistry, J. Mater. Chem. B, Biosensors and Bioelectronics; and presentations at national and international meetings with graduate and undergraduate students co-authors.


Last Modified: 09/30/2016
Modified by: Emanuela S Andreescu

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