| NSF Org: |
CHE Division Of Chemistry |
| Recipient: |
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| Initial Amendment Date: | February 11, 2008 |
| Latest Amendment Date: | November 12, 2009 |
| Award Number: | 0747990 |
| Award Instrument: | Continuing Grant |
| Program Manager: |
George Janini
CHE Division Of Chemistry MPS Directorate for Mathematical and Physical Sciences |
| Start Date: | February 15, 2008 |
| End Date: | January 31, 2013 (Estimated) |
| Total Intended Award Amount: | $400,000.00 |
| Total Awarded Amount to Date: | $400,000.00 |
| Funds Obligated to Date: |
FY 2009 = $240,000.00 |
| History of Investigator: |
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| Recipient Sponsored Research Office: |
21 N PARK ST STE 6301 MADISON WI US 53715-1218 (608)262-3822 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
21 N PARK ST STE 6301 MADISON WI US 53715-1218 |
| Primary Place of
Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): |
ANALYTICAL SEPARATIONS & MEAS., Advanced Tech Education Prog |
| Primary Program Source: |
01000910DB NSF RESEARCH & RELATED ACTIVIT 04000809DB NSF Education & Human Resource |
| Program Reference Code(s): |
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| Program Element Code(s): |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.049 |
ABSTRACT
This CAREER award by the Analytical and Surface Chemistry program supports work by Professor Joshua Coon at the University of Wisconsin - Madison to develop new technologies to characterize the many isoforms and modified versions of gene products generated within living cells. Adaptation of top-down proteomic technologies will provide rapid, robust characterization of whole proteins on a time-scale of less than ~2 seconds/protein. A novel electron transfer dissociation (ETD) enabled linear ion trap-orbitrap mass spectrometer recently constructed in the Coon laboratory will be enhanced by a new high capacity linear RF quadrupole, which will serve as a dedicated ion/ion reaction cell to allow the needed rapid analyses, enabling routine coupling of top-down proteomic measurements for proteins up to at least 70 kDa with chromatographic separations.
The program also entails development of novel K-12 pedagogy that demonstrates the synergy between design (technology) and inquiry (science) in a format that engages both academic and non-academic students. This program ("TESci") combines a diverse group of students and educators to tightly link technology education (TE) and the sciences through an interdisciplinary, team-learning environment. The program is cross-cutting and aims to: (1) foster an interest in the sciences among those least likely to become engaged in scientific research, (2) develop technology skills among college-bound science students, and (3) instill the value of interdisciplinary collaboration and diversity in science. The TESci program will create a hub of excellence for the integration of science and technology education - one that will provide a model for Wisconsin and the nation.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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