| NSF Org: |
TI Translational Impacts |
| Recipient: |
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| Initial Amendment Date: | May 24, 2006 |
| Latest Amendment Date: | May 24, 2006 |
| Award Number: | 0610871 |
| Award Instrument: | Standard Grant |
| Program Manager: |
Muralidharan Nair
TI Translational Impacts TIP Directorate for Technology, Innovation, and Partnerships |
| Start Date: | July 1, 2006 |
| End Date: | December 31, 2006 (Estimated) |
| Total Intended Award Amount: | $99,953.00 |
| Total Awarded Amount to Date: | $99,953.00 |
| Funds Obligated to Date: |
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| Recipient Sponsored Research Office: |
104 MANET RD Chestnut Hill MA US 02467-1120 (617)928-1221 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
104 MANET RD Chestnut Hill MA US 02467-1120 |
| Primary Place of
Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): | SBIR Phase I |
| Primary Program Source: |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.084 |
ABSTRACT
This Small Business Innovation Research (SBIR) Phase I project will demonstrate the feasibility of a temperature-independent surface plasmon resonance (SPR) biosensor for sensitive detection of biological molecules. SPR bio-detection has been used for many years in biomedical research and drug development laboratories. Recent improvement in sensitivity and potentially lower cost enable the use of SPR-based biosensor in diagnostic application, including testing of pathogens, biomarkers, toxins and contaminants. However, current SPR instruments are susceptible to temperature-induced measurement errors that limit their use in the field. The thermal drift in SPR sensors is caused by the dependence of the refractive index of the sensor's optical medium and the sample material on ambient temperature. Currently, this thermal drift is mitigated in laboratory instruments by stabilizing the temperature in the instrument's test chamber and by incorporating temperature compensation channels into the sensor design. However, these active measures increase the instrument's complexity, cost, size and power consumption. The proposed temperature-independent SPR design addresses this fundamental deficiency and reduces by a factor of 100~1000 the thermal sensitivity of a waveguide-based SPR chip by matching the thermo-optic coefficients of the chip's optical substrate and the sample under test.
If successful the proposed project will lead to expansion of the application range and market penetration of SPR biodetection technology. Based on the high-sensitivity and low cost of the proposed SPR sensor, a handheld instrument will be developed to support multiple field and point-of-care diagnostic applications in the areas of emergency medicine, veterinary medicine, food safety, aquaculture and biodefense.
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