Award Abstract # 0412782
Chiral Magic-Number Clusters & Non-Covalent Complexes Studied by Electrospray Ionization & Ion Soft Landing

NSF Org: CHE
Division Of Chemistry
Recipient: PURDUE UNIVERSITY
Initial Amendment Date: July 7, 2004
Latest Amendment Date: April 11, 2006
Award Number: 0412782
Award Instrument: Continuing Grant
Program Manager: Kelsey Cook
CHE  Division Of Chemistry
MPS  Directorate for Mathematical and Physical Sciences
Start Date: July 15, 2004
End Date: June 30, 2008 (Estimated)
Total Intended Award Amount: $791,000.00
Total Awarded Amount to Date: $791,000.00
Funds Obligated to Date: FY 2004 = $329,000.00
FY 2005 = $231,000.00
FY 2006 = $231,000.00
History of Investigator:
  • Robert Cooks (Principal Investigator)
Recipient Sponsored Research Office: Purdue University
 2550 NORTHWESTERN AVE # 1100
 WEST LAFAYETTE
 IN  US  47906-1332
(765)494-1055
Sponsor Congressional District: 04
Primary Place of Performance: Purdue University
 2550 NORTHWESTERN AVE # 1100
 WEST LAFAYETTE
 IN  US  47906-1332
Primary Place of Performance
Congressional District:		 04
Unique Entity Identifier (UEI): YRXVL4JYCEF5
Parent UEI: YRXVL4JYCEF5
NSF Program(s): ANALYTICAL SEPARATIONS & MEAS.
Primary Program Source: app-0106 
app-0104 
app-0105 
Program Reference Code(s): OTHR, 0000
Program Element Code(s): 197400
Award Agency Code: 4900
Fund Agency Code: 4900
Assistance Listing Number(s): 47.049

ABSTRACT

Professor R. Graham Cooks of Purdue University is supported by the Analytical and Surface Chemistry Program to use the soft ionization capabilities of electrosonic spray ionization to generate molecular clusters probed by mass spectrometry. Reactions of these clusters will be carried out at atmospheric pressure prior to introduction of the products into a mass analyzer. Clusters and products are 'soft landed' onto surfaces (liquids and solids) after mass selection and detected using infrared laser desorption. The work focuses on the homochiral clusters of the amino acid serine discovered in the PI's laboratory, and on issues of chiral amplification and transfer of chirality to other species through enantioselective chemical reactions.

Noncovalent bonding is an important topic in understanding interactions between biologically active molecules, as well as in many other areas including colloid chemistry and sensors. Thus, in addition to providing excellent student education, the PI continues to develop mass spectrometry ultimately for biology and security applications, for example.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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(Showing: 1 - 10 of 52)
Chen, H.;Cooks, R. G.;Meurer, E. C.;Eberlin, M. N.; "Hydrogen/chlorine exchange reactions of gaseous carbartions" Journal of the American Society for Mass Spectrometry , v.16 , 2005 , p.2045-2051
Hu, Q.;Makarov, A. A.;Cooks, R. G.;Noll, R. J.; "Resonant ac dipolar excitation for ion motion control in the orbitrap mass analyzer" Journal of Physical Chemistry A , v.110 , 2006 , p.2682-2689
Igor A. Popov, Hao Chen, Oleg N. Kharybin, Eugene N. Nikolaev, R. Graham Cooks "Detection of Explosives on Solid Surfaces by Thermal Desorption and Ambient Ion/Molecule Reactions" Chemical Communications , 2005 , p.1953
Ismael Cotte-Rodrฮฏguez, Zolt?n Tak?ts, Nari Talaty, Huanwen Chen, and R. Graham Cooks "Desorption Electrospray Ionization of Explosives on Surfaces: Sensitivity and Selectivity Enhancement by Reactive Desorption Electrospray Ionization" Anal. Chem. , v.77 , 2005 , p.6755
Ismael Cotte-Rodriguez, Hao Chen and R. Graham Cooks "Rapid Trace Detection of Triacetone Triperoxide (TATP) by Complexation Reactions during Desorption Electrospray Ionization" Chem. Commun. , 2006 , p.953
Kauppila, T. J.;Talaty, N.;Jackson, A. U.;Kotiaho, T.;Kostiainen, R.;Cooks, R. G.; "Carbohydrate and steroid analysis by desorption electrospray ionization mass spectrometry" Chemical Communications , 2008 , p.2674-2676
Nanita, S. C.;Cooks, R. G.; "Negatively-charged halide adducts of homochiral serine octamers" Journal of Physical Chemistry B , v.109 , 2005 , p.4748-4753
Nanita, S. C.;Sokol, E.;Cooks, R. G.; "Alkali metal-cationized serine clusters studied by sonic spray ionization tandem mass spectrometry" Journal of the American Society for Mass Spectrometry , v.18 , 2007 , p.856-868
Ouyang, Z.;Gao, L.;Fico, M.;Chappell, W. J.;Noll, R. J.;Cooks, R. G.; "Quadrupole ion traps and trap arrays: geometry, material, scale, performance" European Journal of Mass Spectrometry , v.13 , 2007 , p.13-18
Pengxiang Yang, R. Graham Cooks, Zheng Ouyang, Adam M. Hawkridge, David C. Muddiman "Soft Protein Ionization Assisted by High Velocity Gas Flow" Analytical Chemistry , v.77 , 2005 , p.6174
Perry, R. H.;Wu, C.;Nefliu, M.;Cooks, R. G.; "Serine Sublimes with Spontaneous Chiral Amplification" Chem. Commun. , 2007 , p.1071-1073
(Showing: 1 - 10 of 52)

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