| NSF Org: |
MCB Division of Molecular and Cellular Biosciences |
| Recipient: |
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| Initial Amendment Date: | March 24, 2003 |
| Latest Amendment Date: | June 11, 2007 |
| Award Number: | 0236093 |
| Award Instrument: | Continuing Grant |
| Program Manager: |
Kamal Shukla
MCB Division of Molecular and Cellular Biosciences BIO Directorate for Biological Sciences |
| Start Date: | May 1, 2003 |
| End Date: | April 30, 2008 (Estimated) |
| Total Intended Award Amount: | $0.00 |
| Total Awarded Amount to Date: | $567,353.00 |
| Funds Obligated to Date: |
FY 2004 = $186,857.00 FY 2005 = $197,000.00 |
| History of Investigator: |
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| Recipient Sponsored Research Office: |
3227 CHEADLE HALL SANTA BARBARA CA US 93106-0001 (805)893-4188 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
3227 CHEADLE HALL SANTA BARBARA CA US 93106-0001 |
| Primary Place of
Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): | Molecular Biophysics |
| Primary Program Source: |
app-0104 app-0105 |
| Program Reference Code(s): |
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| Program Element Code(s): |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.074 |
ABSTRACT
The main objective of this research is to develop innovations in probe microscopy of biomolecular materials. The research will integrate both the imaging and the pulling aspects of probe microscopy to develop models of biomolecular mechanics and structures. Specifically, the work will focus on three significant classes of biomolecular materials, and it will examine two types of biomaterials from each class: (1) Highly elastic biological proteins - spider capture silk and HMW (high molecular weight) glutenin -are good model systems for possible improvements in the elasticity of synthetic materials. (2) Protein mimics to be investigated are polyamino acids and a non-peptide triblock copolymer mimic of the abalone protein lustrin; lustrin is the main protein component of abalone shell, which is 3000 times more fracture resistant than concrete. (3) Novel DNA structures to be investigated are telomeric mimics, and DNA-surfactant liquid-crystalline films, which have been used to study photoconductivity of DNA.
This research will take a multi-directional approach to make innovations in probe microscopy of biomolecular materials. Probing many systems has been a good approach for maximizing the probability of innovation in probe microscopy of biomolecular materials. Undergraduate students will be involved in the research, and some will become co-authors or first authors of peer-reviewed publications.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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