News From the Field
Biologists discover process that neutralizes tumors
July 10, 2018
This material is available primarily for archival purposes. Telephone numbers or other contact information may be out of date; please see current contact information at media contacts.Researchers discovered an unexpected twist in the tumor vs. T cell battle. Tumors employ a protein called PD-L1 to blind T cells from carrying out their functions. PD-L1 protects tumors through a 'molecular brake' known as PD-1. Researchers have found that some tumor cells display not only their PD-L1 weapon, but also the PD-1 'brake,' essentially a neutralizing function. The unexpected mechanism that could help determine whether a cancer patient will respond to immunotherapy.Full Story
University of California, San Diego
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