September 20, 2017

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A detailed study of how domains within the Cas9 protein move when the molecule binds to DNA has allowed the University of California, Berkeley, Harvard University and Massachusettes General Hospital scientists to locate the protein that monitors the fidelity of binding between the Cas9 single-guide RNA and its DNA target. The researchers then tweaked this domain to boost specificity, creating the highest fidelity Cas9 protein to date.Full Story

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University of California, Berkeley

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