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August 24, 2017

Xenopus tadpole brain circuitry

Researchers found that tadpoles use the optic tectum region of their brain to determine that something is approaching and avoid collision. The finding helps scientists better understand how different neurons work together to control simple behavior in many animals.

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Neuroscientists at Brown University looked cell-by-cell at the brain circuitry that tadpoles -- and possibly other animals -- use to avoid collisions. The study produced a model of how individual inhibitory and excitatory neurons can work together to control a simple behavior.

Brown scientists tracked the cell-by-cell progress of neural signals from the eyes through the brains of tadpoles as they saw and reacted to stimuli, including an apparently approaching black circle. In so doing, the researchers were able to gain a novel understanding of how individual cells contribute in a broader network that distinguishes impending collisions. The basic circuitry involved is present in a wide variety of animals, including people, which is no surprise given how fundamental collision avoidance is across animal behavior.

The research was supported in part by the National Science Foundation (grant IOS 07-46558).

To learn more about this research, see the Brown news story Dodging dots helps explain brain circuitry. (Date image taken: 2013; date originally posted to NSF Multimedia Gallery: Aug. 25, 2017)

Credit: Arseny Khakhalin


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