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Model of esperamicin A1 with the "warhead" portion displayed in orange
Model of esperamicin A1 with the "warhead" portion displayed in orange. Esperamicin A1 -- an enediyne -- binds to DNA immediately prior to activation of its warhead, which will cleave the DNA. Enediynes are naturally occurring molecules commonly called biological warheads for their ability to bind to and split tumor's DNA backbones.
[Computations were performed on the National Center for Supercomputing Applications SGI Origin2000 supercomputer, purchased primarily with funds from the U.S. National Science Foundation.] (Year of image: 2001)
Credit: Images by Steven Feldgus; simulation completed using computational resources provided by the National Center for Supercomputing Applications (NCSA)
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