Email Print Share

Impact

New window into brain lets researchers study brain disorders

New technique renders brain 'transparent,' allows scientists to reconstruct neural circuitry

NSF-funded scientists developed a new imaging technology to see into the brain.


NSF-funded scientists developed a new imaging technology to see into the brain.
Credit and Larger Version


January 2, 2018

Until recently, the composition of brain tissue limited researchers' insights into the brain's neural circuitry and function.

NSF-funded scientists developed a technique called CLARITY to chemically dissolve opaque elements and replace them with a hydrogel, essentially rendering the brain transparent. When used with fluorescent markers, CLARITY lets researchers precisely reconstruct the brain's neural circuitry in 3-D and analyze how changes to the brain may underlie certain disorders such as autism or depression.

The technique has been hailed as a breakthrough in neuroscience.

NSF Directorate(s):
Directorate for Biological Sciences

Locations
California

Related Awards
#0724593 In vivo Technology for Fast Optical Control of Neural Circuits

This NSF Impact is one of thousands of research outcomes made possible by NSF that help fuel the U.S. economy, enhance national security and sustain U.S. global leadership by advancing knowledge. You can search for more NSF Impacts at https://www.nsf.gov/impacts.

 Get Impacts by Email