Impact
New window into brain lets researchers study brain disorders
New technique renders brain 'transparent,' allows scientists to reconstruct neural circuitry
NSF-funded scientists developed a new imaging technology to see into the brain.
Credit and Larger Version
January 2, 2018
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Until recently, the composition of brain tissue limited researchers' insights into the brain's neural circuitry and function.
NSF-funded scientists developed a technique called CLARITY to chemically dissolve opaque elements and replace them with a hydrogel, essentially rendering the brain transparent. When used with fluorescent markers, CLARITY lets researchers precisely reconstruct the brain's neural circuitry in 3-D and analyze how changes to the brain may underlie certain disorders such as autism or depression.
The technique has been hailed as a breakthrough in neuroscience.
NSF Directorate(s):
Directorate for Biological Sciences
Locations
California
Related Awards
#0724593 In vivo Technology for Fast Optical Control of Neural Circuits
Related Websites
CLARITY opens window to brain circuitry, new era for neuroscience: https://nsf.gov/news/mmg/mmg_disp.jsp?med_id=78002&from=
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