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Cellular and Biochemical Engineering


CONTACTS
Name Email Phone Room
Steven  W. Peretti speretti@nsf.gov (703) 292-7029   
Steven  M. Zehnder szehnder@nsf.gov (703) 292-7014   


PROGRAM GUIDELINES

Apply to PD 20-1491 as follows:

For full proposals submitted via FastLane: standard NSF Proposal & Award Policies & Procedures Guide proposal preparation guidelines apply.
For full proposals submitted via Grants.gov: the NSF Grants.gov Application Guide: A Guide for the Preparation and Submission of NSF Applications via Grants.gov Guidelines applies. (Note: The NSF Grants.gov Application Guide is available on the Grants.gov website and on the NSF website at: http://www.nsf.gov/publications/pub_summ.jsp?ods_key=grantsgovguide)

Important Information for Proposers

A revised version of the NSF Proposal & Award Policies & Procedures Guide (PAPPG) (NSF 19-1), is effective for proposals submitted, or due, on or after February 25, 2019. Please be advised that, depending on the specified due date, the guidelines contained in NSF 19-1 may apply to proposals submitted in response to this funding opportunity.


DUE DATES

Full Proposal Accepted Anytime

Proposals for this program will be accepted throughout the year.

For additional information regarding the removal of deadlines for this program, please refer to the Dear Colleague Letter (NSF 18-082) and Frequently Asked Questions (NSF 18-083).

Proposals submitted to other program announcements and solicitations, including the Faculty Early Career Development Program (CAREER), must meet their respective deadlines; please refer to the deadline dates specified in the appropriate announcement or solicitation. Proposals for EArly-concept Grants for Exploratory Research (EAGER) or Rapid Response Research (RAPID) can be submitted at any time but Principal Investigators (PIs) must contact the cognizant program director prior to submission. Proposals for supplements or workshops can be submitted at any time, and PIs are encouraged to contact the cognizant program director prior to submission.


SYNOPSIS

The Cellular and Biochemical Engineering (CBE) program is part of the Engineering Biology and Health cluster, which also includes: 1) the Biophotonics program; 2) the Biosensing program; 3) the Disability and Rehabilitation Engineering program; and 4) the Engineering of Biomedical Systems program.

The Cellular and Biochemical Engineering program supports fundamental engineering research that advances understanding of cellular and biomolecular processes. CBE-funded research may lead to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cell, biochemical, biopharmaceutical, and biotechnology industries.

Fundamental to many research projects in this area is the understanding of how biomolecules, subcellular systems, cells, and cell populations interact, and how those interactions lead to changes in structure, function, and behavior. A quantitative treatment of problems related to biological processes is considered vital to successful research projects in the CBE program. 

The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches. The CBE program also encourages proposals that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.

Major areas of interest for the program include:

  • Metabolic engineering and synthetic biology for biomanufacturing, including the design of synthetic metabolic components and synthetic cells, 
  • Quantitative systems biotechnology,
  • Microbiome structure, function, synthesis, and maintenance,
  • Protein and enzyme engineering, and
  • Single cell and population dynamics and modeling in the context of biomanufacturing.

All proposals should include a description on the potential impact of proposed research on an associated biomanufacturing process.

Proposals whose core innovation involves tissue engineering, organ culture, development of models of healthy or diseased physiology, or design and application of technologies focused on the diagnosis or treatment of disease should be submitted to the Engineering of Biomedical Systems program (CBET 5345). 

INFORMATION COMMON TO MOST CBET PROGRAMS

Proposals should address the novelty and/or potentially transformative nature of the proposed work compared to previous work in the field.  Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact of success in the research on society and/or industry.  The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal.

The duration of unsolicited proposal awards in CBET is generally up to three years.  Single-investigator award budgets typically include support for one graduate student (or equivalent) and up to one month of principal investigator time per year (awards for multiple investigator projects are typically larger). Proposal budgets that are much larger than typical should be discussed with the Program Director prior to submission. Proposers can view budget amounts and other information from recent awards made by this program via the “What Has Been Funded (Recent Awards Made Through This Program, with Abstracts)” link towards the bottom of this page.

Faculty Early Career Development (CAREER) program proposals are strongly encouraged.  Award duration is five years.  The submission deadline for Engineering CAREER proposals is in July every year. Learn more in the CAREER program description

Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the Program Director before submission of the proposal.

Grants for Rapid Response Research (RAPID) and EArly-concept Grants for Exploratory Research (EAGER) are also considered when appropriate.  Please note that proposals of these types must be discussed with the program director before submission.  Grant Opportunities for Academic Liaison with Industry (GOALI) proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that RAPID, EAGER, and GOALI proposals can be submitted anytime during the year. Details about RAPID, EAGER, and GOALI are available in the Proposal & Award Policies & Procedures Guide (PAPPG), Part 1, Chapter II, Section E: Types of Proposals.  

Compliance: Proposals that are not compliant with the Proposal & Award Policies & Procedures Guide (PAPPG) will be returned without review.


What Has Been Funded (Recent Awards Made Through This Program, with Abstracts)

Map of Recent Awards Made Through This Program